2-(furan-2-yl)-1H-benzimidazole

C11H8N2O

CAS3878-19-1
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
3878-19-1
EC Number
223-404-0
UN Number
3077
Index Number
613-016-00-3
PubChem CID
19756

Physical-chemical properties

Molecular Formula
C11H8N2O
Molar Mass
184.19 g/mol
IUPAC Name
2-(furan-2-yl)-1H-benzimidazole

Chemical Identifiers

InChI
InChI=1S/C11H8N2O/c1-2-5-9-8(4-1)12-11(13-9)10-6-3-7-14-10/h1-7H,(H,12,13)
InChI Key
UYJUZNLFJAWNEZ-UHFFFAOYSA-N

Overview

2-(furan-2-yl)-1H-benzimidazole (CAS 3878-19-1) is a heterocyclic organic compound featuring both benzimidazole and furan moieties with notable pharmaceutical research applications. This compound represents an important class of fused heterocyclic molecules combining the structural features of benzimidazole and furan rings. The benzimidazole core consists of a benzene ring fused to an imidazole ring, while the furan substituent at the 2-position adds oxygen-containing heterocyclic functionality. With the molecular formula C11H8N2O and a molecular weight of 184.19 g/mol, this compound exhibits the characteristic properties of both ring systems, making it valuable in medicinal chemistry research and pharmaceutical development. From a safety perspective, 2-(furan-2-yl)-1H-benzimidazole carries significant hazard classifications including Category 2 carcinogenicity, acute toxicity, and specific target organ toxicity with repeated exposure. The compound also presents skin sensitization potential and aquatic toxicity concerns, requiring careful handling with appropriate personal protective equipment and environmental controls. These safety characteristics distinguish it from simpler aromatic compounds like 1,4-dichlorobenzene, which primarily presents different toxicity profiles. The compound finds primary applications in pharmaceutical research as a building block for drug discovery programs, particularly in the development of antimicrobial and anticancer agents. It serves as an intermediate in the synthesis of more complex heterocyclic compounds and is utilized in academic research for studying structure-activity relationships in benzimidazole derivatives. Additionally, it functions as a reference standard in analytical chemistry applications. OYSI maintains reliable supply chains for 2-(furan-2-yl)-1H-benzimidazole to support pharmaceutical research and chemical synthesis requirements across European markets.

Safety & Classification

Warning
Classification:

Carc. 2; Acute Tox. 4; STOT RE 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H302

Harmful if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameFuberidazol (ISO)
Marine PollutantNo

Frequently Asked Questions

What is 2-(furan-2-yl)-1H-benzimidazole?

2-(furan-2-yl)-1H-benzimidazole is a heterocyclic organic compound with the molecular formula C11H8N2O and CAS number 3878-19-1. This compound features a benzimidazole ring system substituted with a furan-2-yl group at the 2-position, resulting in a molecular weight of 184.19 g/mol. It belongs to the class of benzimidazole derivatives, which are important structural motifs in pharmaceutical and chemical research applications.

What are the physicochemical properties of 2-(furan-2-yl)-1H-benzimidazole?

2-(furan-2-yl)-1H-benzimidazole is a solid crystalline compound at room temperature with a molecular weight of 184.19 g/mol. The compound contains both nitrogen-containing benzimidazole and oxygen-containing furan ring systems, which influence its polarity and solubility characteristics. Its heterocyclic structure contributes to its stability and chemical reactivity patterns. Specific physical properties such as melting point, boiling point, and solubility data should be confirmed through technical documentation.

What is 2-(furan-2-yl)-1H-benzimidazole used for?

2-(furan-2-yl)-1H-benzimidazole is primarily used as an intermediate in pharmaceutical research and chemical synthesis. The compound serves as a building block for the development of bioactive molecules and pharmaceutical compounds due to its benzimidazole core structure. It may also find applications in materials science research and as a precursor for specialized chemical products. Its specific applications depend on the target industry and research requirements.

How to handle 2-(furan-2-yl)-1H-benzimidazole safely?

2-(furan-2-yl)-1H-benzimidazole must be handled with appropriate personal protective equipment including gloves, safety goggles, and lab coats due to its classification as Acute Tox. 4 and Skin Sens. 1. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid direct skin and eye contact, and ensure proper hygiene practices. Given its carcinogenic classification (Carc. 2), minimize exposure duration and follow strict containment procedures.

How to store 2-(furan-2-yl)-1H-benzimidazole correctly?

2-(furan-2-yl)-1H-benzimidazole should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly closed and properly labeled with appropriate hazard warnings. Due to its aquatic toxicity classification, prevent environmental release during storage. Store in areas with appropriate containment measures and restrict access to authorized personnel only. Maintain storage conditions that prevent degradation and ensure product integrity.

What to do in case of contact with 2-(furan-2-yl)-1H-benzimidazole?

Immediate action is required if contact occurs with 2-(furan-2-yl)-1H-benzimidazole. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water. In case of eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician and provide the safety data sheet.

How to dispose of 2-(furan-2-yl)-1H-benzimidazole appropriately?

2-(furan-2-yl)-1H-benzimidazole waste must be disposed of according to local and national hazardous waste regulations due to its toxic and environmentally hazardous properties. The compound should not be discharged into drains, water courses, or onto the ground given its Aquatic Acute 1 and Aquatic Chronic 1 classifications. Contact licensed waste disposal companies for proper treatment and disposal. Maintain detailed waste disposal records and follow all applicable environmental protection requirements.

How to transport 2-(furan-2-yl)-1H-benzimidazole?

2-(furan-2-yl)-1H-benzimidazole is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation according to dangerous goods transport regulations. Use UN-approved packaging and ensure proper hazard labels are displayed during transport. Transport vehicles must comply with ADR requirements for Class 9 substances, and drivers should carry appropriate emergency response information.

Is 2-(furan-2-yl)-1H-benzimidazole subject to particular regulations?

2-(furan-2-yl)-1H-benzimidazole is subject to REACH regulation for registration, evaluation, and authorization of chemicals in Europe. The compound must be classified and labeled according to CLP regulation with appropriate hazard pictogrammes (GHS07, GHS08, GHS09) and warning signal word. It is not currently listed as a Substance of Very High Concern (SVHC). Users must comply with occupational safety regulations and environmental protection requirements for handling carcinogenic and environmentally hazardous substances.

Where to buy 2-(furan-2-yl)-1H-benzimidazole in Europe?

2-(furan-2-yl)-1H-benzimidazole is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides reliable supply chains across Europe with proper documentation including safety data sheets and certificates of analysis. As a professional chemical distributor, OYSI ensures compliance with all relevant European regulations including REACH requirements. Contact OYSI directly for availability, specifications, and delivery options to your location within Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.