3-(4-chlorophenyl)-1-methoxy-1-methylurea

C9H11ClN2O2

CAS1746-81-2
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
1746-81-2
EC Number
217-129-5
UN Number
3077
Index Number
006-032-00-1
PubChem CID
15629

Physical-chemical properties

Molecular Formula
C9H11ClN2O2
Molar Mass
214.65 g/mol
IUPAC Name
3-(4-chlorophenyl)-1-methoxy-1-methylurea

Chemical Identifiers

InChI
InChI=1S/C9H11ClN2O2/c1-12(14-2)9(13)11-8-5-3-7(10)4-6-8/h3-6H,1-2H3,(H,11,13)
InChI Key
LKJPSUCKSLORMF-UHFFFAOYSA-N

Overview

3-(4-chlorophenyl)-1-methoxy-1-methylurea (CAS 1746-81-2) is a substituted urea compound with herbicidal properties and moderate aquatic toxicity. This chlorinated aromatic urea derivative represents an important class of organic compounds widely utilized in agricultural and industrial applications. With the molecular formula C9H11ClN2O2 and a molecular weight of 214.65 g/mol, this substance features a characteristic urea backbone substituted with a 4-chlorophenyl group and methoxy-methyl functionalities. The compound is assigned the EC number 217-129-5 and falls under ADR transport class 9, indicating it requires special handling considerations during shipping and storage. From a safety perspective, 3-(4-chlorophenyl)-1-methoxy-1-methylurea is classified with several hazard categories including Acute Toxicity Category 4 and Specific Target Organ Toxicity (Repeated Exposure) Category 2. The substance poses significant environmental concerns, being classified as both Aquatic Acute Category 1 and Aquatic Chronic Category 1, requiring careful environmental risk management. The associated GHS pictograms (GHS07, GHS08, GHS09) and Warning signal word reflect these moderate to serious health and environmental hazards. Industrial applications primarily focus on herbicide formulations and plant growth regulation, where the compound's selective biological activity proves valuable. The substance also finds use in pharmaceutical intermediate synthesis and specialized chemical manufacturing processes. Unlike structurally different compounds such as 2,3-bis(2-sulfanylethylsulfanyl)propane-1-thiol, this urea derivative exhibits specific phytotoxic properties that make it particularly suitable for agricultural applications. OYSI maintains reliable supply chains for 3-(4-chlorophenyl)-1-methoxy-1-methylurea, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameMonolinuron (ISO)
Marine PollutantNo

Frequently Asked Questions

What is 3-(4-chlorophenyl)-1-methoxy-1-methylurea?

3-(4-chlorophenyl)-1-methoxy-1-methylurea is a synthetic organic compound with the molecular formula C9H11ClN2O2 and CAS number 1746-81-2. This substituted urea derivative contains a chlorinated phenyl ring and methoxy-methyl substituents on the urea nitrogen. With a molecular weight of 214.65 g/mol, it belongs to the class of phenylurea compounds and is classified as hazardous with specific toxicological and environmental concerns requiring careful handling.

What are the physicochemical properties of 3-(4-chlorophenyl)-1-methoxy-1-methylurea?

3-(4-chlorophenyl)-1-methoxy-1-methylurea is a solid compound at room temperature with a molecular weight of 214.65 g/mol. The presence of the chlorophenyl group and urea functionality influences its polarity and solubility characteristics. The compound contains both hydrophobic aromatic components and polar urea groups, affecting its dissolution behavior in various solvents. Specific physical properties like melting point, color, and exact solubility data should be confirmed through technical specifications.

What is 3-(4-chlorophenyl)-1-methoxy-1-methylurea used for?

3-(4-chlorophenyl)-1-methoxy-1-methylurea is primarily used as an intermediate in pharmaceutical and agrochemical synthesis. Its urea structure makes it valuable for developing herbicides, pesticides, and pharmaceutical compounds. The compound serves as a building block in organic synthesis where selective substitution patterns are required. Industrial applications may include specialty chemical manufacturing and research purposes, particularly in developing crop protection products and medicinal chemistry applications.

How to handle 3-(4-chlorophenyl)-1-methoxy-1-methylurea safely?

3-(4-chlorophenyl)-1-methoxy-1-methylurea requires careful handling due to its Acute Tox. 4 and STOT RE 2 classifications. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume extraction systems. Avoid inhalation, skin contact, and ingestion. Handle in accordance with GHS07 and GHS08 pictogram warnings, implementing proper hygiene measures and emergency procedures.

How to store 3-(4-chlorophenyl)-1-methoxy-1-methylurea correctly?

3-(4-chlorophenyl)-1-methoxy-1-methylurea should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from incompatible materials. Keep containers upright and properly labeled with hazard information. Storage areas must be equipped with appropriate spill containment measures due to its aquatic toxicity classification. Maintain storage temperatures according to supplier specifications and ensure access is restricted to authorized personnel only. Regular container inspection is recommended.

What to do in case of contact with 3-(4-chlorophenyl)-1-methoxy-1-methylurea?

Immediate action is required following exposure to 3-(4-chlorophenyl)-1-methoxy-1-methylurea due to its acute toxicity. For skin contact, remove contaminated clothing and rinse thoroughly with water for at least 15 minutes. If inhaled, move to fresh air immediately. In case of eye contact, flush with clean water for 15 minutes. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult safety data sheets and contact emergency services if symptoms develop.

How to dispose of 3-(4-chlorophenyl)-1-methoxy-1-methylurea appropriately?

3-(4-chlorophenyl)-1-methoxy-1-methylurea disposal must comply with local and European waste regulations due to its environmental hazard classification (Aquatic Acute 1, Aquatic Chronic 1). The substance requires disposal through licensed hazardous waste contractors and cannot be released into water systems or soil. Incineration at authorized high-temperature facilities may be appropriate. Container disposal must follow specific protocols, and all disposal activities should be documented according to regulatory requirements.

How to transport 3-(4-chlorophenyl)-1-methoxy-1-methylurea?

3-(4-chlorophenyl)-1-methoxy-1-methylurea is classified as ADR Class 9 (Miscellaneous Dangerous Goods), Packing Group III for transport purposes. Packaging must comply with UN specifications for Class 9 materials, requiring proper marking, labeling, and documentation. Transport vehicles need appropriate placarding and emergency information. Drivers require hazardous goods training certification. All transport documentation must include proper shipping names, UN numbers, and emergency response information according to ADR regulations.

Is 3-(4-chlorophenyl)-1-methoxy-1-methylurea subject to specific regulations?

3-(4-chlorophenyl)-1-methoxy-1-methylurea is subject to European REACH and CLP regulations requiring registration, classification, and labeling compliance. The compound is not currently identified as an SVHC (Substance of Very High Concern). Suppliers must provide safety data sheets and ensure proper hazard communication. Users must implement risk management measures according to exposure scenarios. Additional national regulations may apply for specific uses, particularly in professional and industrial applications.

Where to buy 3-(4-chlorophenyl)-1-methoxy-1-methylurea in Europe?

3-(4-chlorophenyl)-1-methoxy-1-methylurea is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this compound with full regulatory compliance including safety data sheets, certificates of analysis, and proper hazard classification documentation. As a professional chemical distributor, OYSI ensures reliable supply chains and technical support for industrial customers across Europe requiring this specialized urea derivative for synthesis and manufacturing applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.