2-chloro-N-(4-methylphenyl)acetamide

2-chloro-N-(4-methylphenyl)acetamide is an organic chemical compound with the molecular formula C9H10ClNO and CAS number 16634-82-5. This chloroacetamide derivative has a molecular weight of 183.63 g/mol and belongs to the family of substituted acetamides. The compound features a chlorine atom attached to an acetyl group, which is linked to a para-methylated aniline moiety, making it an important intermediate in organic synthesis and pharmaceutical applications.

2-chloro-N-(4-methylphenyl)acetamide is typically a crystalline solid at room temperature with a molecular weight of 183.63 g/mol. The compound contains both hydrophilic (amide group) and hydrophobic (aromatic ring) regions, affecting its solubility profile. Its physicochemical behavior is influenced by the presence of the chlorine substituent and the para-methyl group on the benzene ring, which impact its melting point, solubility in various solvents, and stability under different conditions.

2-chloro-N-(4-methylphenyl)acetamide is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. The compound serves as a building block for the production of various active pharmaceutical ingredients and fine chemicals. Its reactive chloroacetamide structure makes it valuable in medicinal chemistry for developing new drug compounds, particularly those targeting specific biological pathways. It may also find applications in agrochemical synthesis and specialty chemical manufacturing processes.

2-chloro-N-(4-methylphenyl)acetamide requires careful handling due to its classification as Eye Dam. 1 and Skin Sens. 1, indicating severe eye damage potential and skin sensitization properties. Always wear appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and protective clothing. Work in well-ventilated areas or under fume hoods to minimize inhalation exposure. Avoid direct contact with skin and eyes, and wash hands thoroughly after handling. Follow proper hygiene practices and emergency procedures.

2-chloro-N-(4-methylphenyl)acetamide should be stored in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. Keep containers tightly closed to prevent moisture absorption and contamination. Store separately from incompatible materials such as strong bases, oxidizing agents, and reducing agents. Ensure storage areas are equipped with appropriate spill containment measures and maintain proper inventory management. Check containers regularly for signs of deterioration or leakage.

In case of eye contact with 2-chloro-N-(4-methylphenyl)acetamide, immediately flush with plenty of clean water for at least 15 minutes and seek medical attention due to its Eye Dam. 1 classification. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water. If skin sensitization occurs, avoid further exposure. In case of inhalation, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention. Always consult safety data sheets for specific first aid measures.

2-chloro-N-(4-methylphenyl)acetamide must be disposed of according to local and national hazardous waste regulations due to its environmental hazard classification (Aquatic Acute 1; Aquatic Chronic 1). Do not discharge into waterways, soil, or sewage systems. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities may require incineration at authorized high-temperature facilities. Keep detailed disposal records and ensure compliance with REACH and local environmental protection requirements.

2-chloro-N-(4-methylphenyl)acetamide is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transport purposes. This classification indicates it presents a relatively lower degree of danger during transport but still requires proper packaging, labeling, and documentation. Use appropriate UN-specification packaging and ensure proper marking and placarding of transport vehicles. Transport documentation must include proper shipping names, hazard class, and emergency contact information according to ADR regulations.

2-chloro-N-(4-methylphenyl)acetamide is subject to European chemical regulations including REACH and CLP. The compound is not currently listed as a Substance of Very High Concern (SVHC). It must be classified and labeled according to CLP regulation with appropriate hazard pictogrammes (GHS05, GHS07, GHS09) and danger signal word. Registration requirements under REACH apply for manufacturers and importers above tonnage thresholds. Users must comply with occupational safety regulations and environmental protection requirements.

2-chloro-N-(4-methylphenyl)acetamide is available through OYSI, a leading European distributor of specialty chemicals and pharmaceutical intermediates. OYSI provides high-quality chemical products with proper documentation including certificates of analysis, safety data sheets, and regulatory compliance information. As an established European supplier, OYSI ensures reliable supply chains and technical support for customers across various industries requiring this chemical intermediate for research and manufacturing applications.