2-chloro-N-(4-methylphenyl)acetamide

2-chloro-N-(4-methylphenyl)acetamide is an organic chemical compound with the molecular formula C9H10ClNO and CAS number 16634-82-5. This acetamide derivative contains a chloro-substituted acetyl group attached to a para-methylaniline moiety. With a molecular weight of 183.63 g/mol, it is classified as a hazardous substance requiring careful handling due to its potential for causing serious eye damage, skin sensitization, and aquatic toxicity.

2-chloro-N-(4-methylphenyl)acetamide is a solid organic compound at room temperature with a molecular weight of 183.63 g/mol. The compound features a chloroacetamide structure with aromatic characteristics due to the methylphenyl group. Its specific physical properties such as melting point, solubility, and appearance may vary depending on purity and crystalline form. The presence of both polar amide and aromatic components influences its solubility behavior in different solvents.

2-chloro-N-(4-methylphenyl)acetamide is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. Its chloroacetamide structure makes it valuable for chemical transformations and as a building block in the production of more complex molecules. The compound may also serve in research applications for developing new chemical entities. Due to its reactive chloro group, it is particularly useful in nucleophilic substitution reactions and coupling processes.

2-chloro-N-(4-methylphenyl)acetamide must be handled with appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation. Given its Eye Dam. 1 and Skin Sens. 1 classifications, direct contact must be strictly avoided. Emergency eyewash stations and safety showers should be readily accessible when working with this compound.

2-chloro-N-(4-methylphenyl)acetamide should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from incompatible materials. Keep containers away from heat sources, ignition sources, and direct sunlight. Storage areas should be equipped with appropriate spill containment measures due to its aquatic toxicity classification. The compound should be segregated from strong oxidizers, bases, and reducing agents to prevent unwanted reactions or decomposition.

Immediate action is required if contact occurs with 2-chloro-N-(4-methylphenyl)acetamide due to its serious hazard classifications. For eye contact, rinse immediately with plenty of water for at least 15 minutes and seek immediate medical attention due to Eye Dam. 1 classification. For skin contact, wash thoroughly with soap and water and remove contaminated clothing. If inhaled, move to fresh air immediately. Seek medical attention promptly in all cases of exposure.

2-chloro-N-(4-methylphenyl)acetamide must be disposed of according to local, regional, and national regulations as hazardous waste. Due to its Aquatic Acute 1 and Aquatic Chronic 1 classifications, it cannot be released into the environment or sewage systems. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities may require incineration at authorized facilities equipped to handle chlorinated organic compounds while preventing environmental contamination.

2-chloro-N-(4-methylphenyl)acetamide is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation according to dangerous goods regulations. Packages must display the proper shipping name, UN number, and hazard labels including GHS pictograms GHS05, GHS07, and GHS09. Transportation should only be conducted by trained personnel familiar with dangerous goods handling procedures.

2-chloro-N-(4-methylphenyl)acetamide is subject to various chemical regulations including REACH registration requirements in Europe and CLP classification obligations. The compound carries the signal word 'Danger' and requires appropriate hazard communication through safety data sheets and labeling with GHS pictograms. While not currently listed as an SVHC substance, it must comply with occupational health and safety regulations due to its hazardous properties and environmental restrictions due to aquatic toxicity.

2-chloro-N-(4-methylphenyl)acetamide is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this compound to industrial customers, research institutions, and professional users across Europe with proper documentation including certificates of analysis and safety data sheets. As a regulated hazardous substance, purchases typically require verification of intended use and compliance with local handling and storage requirements. Contact OYSI directly for availability, specifications, and regulatory support.