2-chloro-6-nitro-3-phenoxyaniline
C12H9ClN2O3
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Identification
- CAS Number
- 74070-46-5
- EC Number
- 277-704-1
- UN Number
- 3077
- Index Number
- 612-120-00-6
- PubChem CID
- 92389
Physical-chemical properties
- Molecular Formula
- C12H9ClN2O3
- Molar Mass
- 264.66 g/mol
- IUPAC Name
- 2-chloro-6-nitro-3-phenoxyaniline
Chemical Identifiers
- InChI
- InChI=1S/C12H9ClN2O3/c13-11-10(18-8-4-2-1-3-5-8)7-6-9(12(11)14)15(16)17/h1-7H,14H2
- InChI Key
- DDBMQDADIHOWIC-UHFFFAOYSA-N
Overview
2-chloro-6-nitro-3-phenoxyaniline (CAS 74070-46-5) is an aromatic aniline derivative with chloro, nitro, and phenoxy substituents exhibiting significant biological activity. This specialized chemical compound, with the molecular formula C12H9ClN2O3 and a molecular weight of 264.66 g/mol, represents an important intermediate in pharmaceutical and agrochemical synthesis. The molecule features a complex substitution pattern on the aniline ring system, combining electron-withdrawing groups (chloro and nitro) with an electron-donating phenoxy group, which significantly influences its reactivity and biological properties. From a safety perspective, 2-chloro-6-nitro-3-phenoxyaniline requires careful handling due to its classification as a Category 2 carcinogen and Category 1A skin sensitizer. The compound displays GHS08, GHS07, and GHS09 pictograms with a "Warning" signal word, indicating potential health hazards and environmental concerns. Its classification as Aquatic Acute 1 and Aquatic Chronic 1 emphasizes the need for proper environmental protection measures during storage, handling, and disposal. Transportation falls under ADR Class 9 (miscellaneous dangerous substances), requiring appropriate logistics protocols. Industrial applications primarily focus on pharmaceutical intermediate synthesis, where its unique substitution pattern makes it valuable for developing active pharmaceutical ingredients. The compound also finds use in specialty dye manufacturing and advanced material synthesis. Unlike simpler aromatic compounds such as 1,4-dichlorobenzene, this molecule's complexity allows for highly specific chemical transformations in synthetic chemistry applications. OYSI maintains reliable supply chains for 2-chloro-6-nitro-3-phenoxyaniline, ensuring consistent availability for European industrial customers requiring this specialized pharmaceutical intermediate.
Safety & Classification
Carc. 2; Skin Sens. 1A; Aquatic Acute 1; Aquatic Chronic 1
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| Tunnel Code | - |
| Proper Shipping Name | Aclonifen (ISO) |
| Marine Pollutant | No |
Frequently Asked Questions
What is 2-chloro-6-nitro-3-phenoxyaniline?
2-chloro-6-nitro-3-phenoxyaniline is an organic chemical compound with the molecular formula C12H9ClN2O3 and CAS number 74070-46-5. This aromatic amine features a complex structure containing chloro, nitro, and phenoxy functional groups attached to an aniline backbone. With a molecular weight of 264.66 g/mol, it is classified as a hazardous substance requiring careful handling due to its carcinogenic potential and sensitizing properties.
What are the physicochemical properties of 2-chloro-6-nitro-3-phenoxyaniline?
2-chloro-6-nitro-3-phenoxyaniline is typically a solid compound at room temperature with a molecular weight of 264.66 g/mol. As an aromatic amine with multiple substituents, it likely exhibits limited water solubility but may be soluble in organic solvents. The presence of nitro and chloro groups affects its stability and reactivity. Specific physical properties such as melting point, boiling point, and exact solubility data should be confirmed through technical data sheets.
What is 2-chloro-6-nitro-3-phenoxyaniline used for?
2-chloro-6-nitro-3-phenoxyaniline serves primarily as a chemical intermediate in organic synthesis and pharmaceutical manufacturing. Its complex aromatic structure makes it valuable for developing specialty chemicals, dyes, and potentially active pharmaceutical ingredients. The compound may also be used in research and development applications within the chemical industry. Due to its hazardous classification, its use is typically restricted to professional industrial settings with appropriate safety measures.
How to safely handle 2-chloro-6-nitro-3-phenoxyaniline?
2-chloro-6-nitro-3-phenoxyaniline requires strict safety protocols due to its carcinogenic and sensitizing properties. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under fume hoods. Avoid inhalation and direct contact with skin or eyes. Implement proper hygiene measures including thorough handwashing after handling. Emergency procedures should be readily available.
How to properly store 2-chloro-6-nitro-3-phenoxyaniline?
2-chloro-6-nitro-3-phenoxyaniline should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from incompatible materials. Keep away from heat sources, direct sunlight, and oxidizing agents. Store separately from food, beverages, and animal feed. Ensure storage areas are equipped with appropriate spill containment measures and emergency equipment. Access should be restricted to trained personnel only, with proper labeling maintained at all times.
What to do in case of contact with 2-chloro-6-nitro-3-phenoxyaniline?
Immediate action is required upon contact with 2-chloro-6-nitro-3-phenoxyaniline. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. If eyes are affected, flush immediately with clean water for 15-20 minutes. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting. Seek immediate medical attention in all cases and provide safety data sheet information to medical personnel.
How to properly dispose of 2-chloro-6-nitro-3-phenoxyaniline?
2-chloro-6-nitro-3-phenoxyaniline must be disposed of as hazardous waste through licensed waste management companies in accordance with local, national, and EU regulations. The substance cannot be disposed of in regular waste streams due to its environmental hazard classification (Aquatic Acute 1, Aquatic Chronic 1). Containers should be properly labeled and segregated. Consult local environmental authorities for specific disposal requirements and approved waste treatment facilities in your region.
How to transport 2-chloro-6-nitro-3-phenoxyaniline?
2-chloro-6-nitro-3-phenoxyaniline is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transport purposes. This classification requires specific packaging, labeling, and documentation according to dangerous goods regulations. Transport must be carried out by certified dangerous goods transporters with appropriate vehicle markings and emergency equipment. Proper shipping papers and emergency response information must accompany shipments. Consult ADR regulations for complete transport requirements.
Is 2-chloro-6-nitro-3-phenoxyaniline subject to specific regulations?
2-chloro-6-nitro-3-phenoxyaniline is subject to multiple European regulations including REACH registration requirements and CLP classification as Carc. 2, Skin Sens. 1A, and aquatic hazard categories. While not currently listed as an SVHC, its carcinogenic classification may trigger additional regulatory scrutiny. Users must comply with occupational health regulations, environmental protection laws, and proper labeling requirements. Industrial users should verify current regulatory status and any use restrictions before handling.
Where to buy 2-chloro-6-nitro-3-phenoxyaniline in Europe?
2-chloro-6-nitro-3-phenoxyaniline is available through OYSI, a specialized European distributor of technical chemicals. As a professional chemical supplier, OYSI provides this regulated substance to qualified industrial customers with proper safety documentation and regulatory compliance support. Due to the hazardous nature of this compound, purchases are typically restricted to businesses with appropriate handling capabilities and regulatory permits. Contact OYSI directly for availability, specifications, and ordering requirements.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.