5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole

5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole is an organosulfur heterocyclic compound with the molecular formula C5H5Cl3N2OS and CAS number 2593-15-9. This chemical features a thiadiazole ring substituted with an ethoxy group and a trichloromethyl group, giving it a molecular weight of 247.5 g/mol. It is classified as a hazardous substance with carcinogenic, acute toxicity, skin sensitizing, and aquatic toxicity properties.

5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole is a solid compound at room temperature with a molecular weight of 247.5 g/mol. The presence of the trichloromethyl group contributes to its chemical stability and influences its solubility characteristics. As a chlorinated heterocyclic compound, it exhibits moderate polarity due to the ethoxy substituent and the nitrogen-sulfur heterocycle, affecting its dissolution behavior in various solvents.

5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole is primarily used as an intermediate in pharmaceutical synthesis and chemical research applications. Its thiadiazole structure makes it valuable in the development of bioactive compounds and agrochemicals. The compound serves as a building block for more complex molecules in medicinal chemistry, particularly in the synthesis of compounds with antimicrobial or pesticidal properties, though specific applications require careful risk assessment due to its hazardous classification.

5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole must be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Given its Skin Sens. 1 and Acute Tox. 4 classifications, direct contact must be avoided. Work should be conducted in a fume hood with proper ventilation, and handlers should be trained in chemical safety procedures. Emergency shower and eyewash stations should be readily accessible.

5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. The container must be kept tightly closed and properly labeled with hazard warnings. Storage areas should be equipped with appropriate containment measures and restricted access due to its carcinogenic classification (Carc. 2). Regular inspection of containers for damage or leakage is essential, and inventory should be managed using first-in, first-out principles.

Immediate decontamination is essential following contact with 5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole. For skin contact, remove contaminated clothing and rinse affected areas with plenty of water for at least 15 minutes. In case of eye contact, flush with water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Seek medical attention promptly, especially given the compound's acute toxicity and sensitizing properties, and provide the safety data sheet to medical personnel.

5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole must be disposed of as hazardous waste through licensed waste management contractors in compliance with local and European regulations. Due to its carcinogenic properties and environmental toxicity (Aquatic Acute 1, Aquatic Chronic 1), it cannot be disposed of in regular waste streams. Containers should be properly labeled, and waste manifests must accompany disposal. Incineration at approved high-temperature facilities is typically the preferred disposal method for chlorinated organic compounds.

5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. Packages must bear appropriate hazard labels and be properly documented with shipping papers including the UN number and proper shipping name. Transportation should be conducted by trained personnel using vehicles equipped for hazardous materials transport, following ADR regulations for packaging, loading, and route restrictions throughout Europe.

5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole is subject to REACH registration requirements and CLP classification regulations in Europe. While not currently listed as an SVHC, its Carc. 2 classification requires compliance with occupational exposure limits and worker protection measures. The compound may be subject to authorization or restriction procedures under REACH, and users must ensure proper risk assessment and implementation of risk management measures as outlined in safety data sheets and exposure scenarios.

5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole is available through OYSI, a leading European distributor of specialty chemicals. OYSI provides this compound to qualified industrial and research customers with proper documentation and safety data sheets. Due to the hazardous nature of this substance, purchases typically require verification of end-use applications and appropriate handling capabilities. Contact OYSI's technical team for availability, packaging options, and regulatory compliance support for your specific requirements.