2-chloro-4-nitroaniline
C6H5ClN2O2
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Identification
- CAS Number
- 121-87-9
- EC Number
- 204-502-2
- UN Number
- 2237
- Index Number
- 610-009-00-7
- PubChem CID
- 8492
Physical-chemical properties
- Molecular Formula
- C6H5ClN2O2
- Molar Mass
- 172.57 g/mol
- IUPAC Name
- 2-chloro-4-nitroaniline
Chemical Identifiers
- InChI
- InChI=1S/C6H5ClN2O2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3H,8H2
- InChI Key
- LOCWBQIWHWIRGN-UHFFFAOYSA-N
Overview
2-chloro-4-nitroaniline (CAS 121-87-9) is a substituted aromatic amine featuring both chloro and nitro substituents on the benzene ring. This chemical compound belongs to the family of chloronitroanilines, which are important intermediates in organic synthesis and industrial chemistry. The presence of both electron-withdrawing groups (chlorine and nitro) on the aniline structure significantly influences its reactivity and chemical behavior. With a molecular weight of 172.57 g/mol and the formula C6H5ClN2O2, this compound exhibits distinctive properties that make it valuable for various industrial applications. The compound is classified under acute toxicity category 4 and chronic aquatic toxicity category 2, requiring careful handling procedures and appropriate safety measures. It falls under ADR transport class 6.1, indicating its classification as a toxic substance requiring special transportation considerations. The GHS pictograms GHS07 and GHS09 highlight both health hazards and environmental concerns associated with this material. In industrial applications, 2-chloro-4-nitroaniline serves primarily as an intermediate in the synthesis of dyes, pigments, and pharmaceuticals. It is particularly useful in the production of azo dyes and various organic colorants where the specific substitution pattern provides desired color properties and stability. The compound also finds application in the synthesis of agrochemicals and specialty chemicals. Similar to other substituted anilines like (3-methylphenyl) N-methylcarbamate, it plays a crucial role in the development of various nitrogen-containing organic compounds. Related compounds such as 2-cyclohexylidene-2-phenylacetonitrile share similar applications in pharmaceutical intermediate synthesis. OYSI maintains reliable supply chains for 2-chloro-4-nitroaniline to support European industrial customers requiring this specialized chemical intermediate.
Safety & Classification
Acute Tox. 4 *; Aquatic Chronic 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 2237 |
| ADR Class | 6.1 |
| Packing Group | III |
| Tunnel Code | E |
| Proper Shipping Name | 2-Chlor-4-nitroanilin, fest |
| Marine Pollutant | No |
Frequently Asked Questions
What is 2-chloro-4-nitroaniline?
2-chloro-4-nitroaniline is an organic chemical compound with the molecular formula C6H5ClN2O2 and CAS number 121-87-9. This aromatic amine derivative contains both chlorine and nitro functional groups attached to an aniline base structure. With a molecular weight of 172.57 g/mol, it appears as a crystalline solid and is classified as moderately toxic and harmful to aquatic environments with long-lasting effects.
What are the physicochemical properties of 2-chloro-4-nitroaniline?
2-chloro-4-nitroaniline is typically a yellow to orange crystalline solid at room temperature. It has limited solubility in water but dissolves well in organic solvents such as ethanol and acetone. The compound exhibits typical aromatic characteristics with melting and boiling points consistent with substituted anilines. Its stability can be affected by light and heat, requiring appropriate storage conditions to maintain product integrity.
What is 2-chloro-4-nitroaniline used for?
2-chloro-4-nitroaniline serves primarily as an intermediate in pharmaceutical and dye manufacturing. It is commonly used in the synthesis of various organic compounds, particularly in the production of azo dyes and pharmaceutical active ingredients. The compound also finds applications in research and development laboratories for chemical synthesis and as a building block for more complex molecular structures in fine chemical manufacturing.
How to handle 2-chloro-4-nitroaniline safely?
2-chloro-4-nitroaniline requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation. The compound is classified as Acute Tox. 4, requiring precautions to prevent skin contact, ingestion, or inhalation. Wash hands thoroughly after handling and avoid eating or drinking in work areas.
How to store 2-chloro-4-nitroaniline correctly?
2-chloro-4-nitroaniline should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep away from incompatible materials such as strong oxidizing agents, acids, and bases. The storage area should be secure and accessible only to trained personnel. Maintain proper labeling with hazard information and ensure containers are in good condition to prevent leaks or contamination.
What to do in case of contact with 2-chloro-4-nitroaniline?
In case of skin contact with 2-chloro-4-nitroaniline, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If eye contact occurs, rinse immediately with plenty of clean water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician if symptoms persist.
How to dispose of 2-chloro-4-nitroaniline appropriately?
2-chloro-4-nitroaniline must be disposed of as hazardous chemical waste according to local and national environmental regulations. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Never dispose of this compound in regular trash, down drains, or into the environment due to its toxicity and environmental persistence. Maintain proper documentation of disposal activities and ensure compliance with all applicable waste management regulations.
How to transport 2-chloro-4-nitroaniline?
2-chloro-4-nitroaniline is classified under ADR Class 6.1 (toxic substances), Packing Group III for transportation. Packages must be properly labeled with appropriate hazard labels and UN identification numbers. Transport should comply with dangerous goods regulations including proper documentation, vehicle placarding, and driver certification. Use appropriate packaging that meets UN specification requirements and ensure proper segregation from incompatible materials during transport.
Is 2-chloro-4-nitroaniline subject to specific regulations?
2-chloro-4-nitroaniline is subject to REACH regulation for registration, evaluation, and authorization of chemicals in Europe. It must comply with CLP regulation for classification, labeling, and packaging requirements. The compound is not currently listed as a Substance of Very High Concern (SVHC). Users must maintain safety data sheets, implement risk management measures, and comply with occupational exposure limits and environmental protection requirements as specified by relevant authorities.
Where to buy 2-chloro-4-nitroaniline in Europe?
2-chloro-4-nitroaniline is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this compound to industrial customers, research institutions, and chemical manufacturers across Europe. As a professional chemical supplier, OYSI ensures proper documentation, regulatory compliance, and quality standards. Contact OYSI directly for availability, technical specifications, and ordering information for your specific application requirements.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.