(1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol

(1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol is a complex organic compound with CAS number 15879-93-3. This chlorinated carbohydrate derivative has a molecular formula of C8H11Cl3O6 and a molecular weight of 309.5 g/mol. The compound features a furanose ring structure with multiple hydroxyl groups and a trichloromethyl substituent, making it a specialized chemical intermediate used in synthetic chemistry applications.

(1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol is a solid crystalline compound at room temperature. The presence of multiple hydroxyl groups suggests good solubility in polar solvents like water and alcohols, while the trichloromethyl group may impart some lipophilic character. The compound's high molecular weight and complex stereochemistry contribute to its stability under normal storage conditions, though it requires careful handling due to its toxicological profile.

(1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol is primarily used as a chemical intermediate in pharmaceutical and fine chemical synthesis. Its unique stereochemistry and functional groups make it valuable for the preparation of complex organic molecules, particularly in the development of antiviral compounds and nucleoside analogs. The compound serves as a building block in medicinal chemistry research and specialized chemical manufacturing processes.

(1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol requires strict safety precautions due to its Acute Tox. 3 and 4 classifications. Always wear appropriate PPE including nitrile gloves, safety goggles, and lab coat. Work in a well-ventilated area or fume hood to prevent inhalation. Avoid skin and eye contact. Use non-sparking tools and equipment. Ensure emergency eyewash and shower facilities are accessible. Train personnel on proper handling procedures before use.

(1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol must be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed and store in secondary containment to prevent environmental release due to its aquatic toxicity classification. Maintain storage temperature below 25°C and protect from light. Store separately from oxidizing agents, bases, and reactive metals. Implement restricted access due to its toxic nature.

Immediate action is required upon contact with (1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol due to its acute toxicity. For skin contact: remove contaminated clothing and rinse with plenty of water for 15 minutes. For eye contact: flush immediately with water for 15 minutes. If inhaled: move to fresh air immediately. If swallowed: do not induce vomiting, rinse mouth with water. Seek immediate medical attention in all cases and provide safety data sheet to medical personnel.

(1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol must be disposed of as hazardous waste through licensed waste management companies. Due to its acute toxicity and environmental hazard classifications, it cannot be discharged to sewers or waterways. Incineration at high temperature in specialized facilities is typically required. Follow local and national regulations for hazardous waste disposal. Maintain proper documentation and waste tracking records throughout the disposal process.

(1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol is classified under ADR Class 6.1, Packing Group III for transportation. This indicates it's a toxic substance with moderate danger level. Use UN-approved packaging suitable for Packing Group III liquids or solids. Proper shipping documentation, hazard labels (Class 6.1), and emergency response information must accompany shipments. Transport vehicles require appropriate placarding and drivers need ADR certification for dangerous goods transport.

(1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol is subject to REACH registration requirements if manufactured or imported above 1 ton per year. Under CLP regulation, it requires hazard classification and labeling with GHS06 and GHS09 pictograms. The compound is not currently listed as SVHC. Additional national restrictions may apply due to its toxicity profile. Companies must maintain safety data sheets and ensure proper worker training and environmental protection measures.

(1R)-1-[(2R,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. OYSI provides technical support, proper documentation, and ensures compliance with European chemical regulations. Due to the compound's specialized nature and safety requirements, purchase from established chemical distributors with appropriate handling capabilities and regulatory expertise is essential for safe procurement and delivery.