1,2,3-trichloropropane

C3H5Cl3

CAS96-18-4
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
Danger

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Identification

CAS Number
96-18-4
EC Number
202-486-1
UN Number
2810
Index Number
602-062-00-X
PubChem CID
7285

Physical-chemical properties

Molecular Formula
C3H5Cl3
Molar Mass
147.43 g/mol
IUPAC Name
1,2,3-trichloropropane

Chemical Identifiers

InChI
InChI=1S/C3H5Cl3/c4-1-3(6)2-5/h3H,1-2H2
InChI Key
CFXQEHVMCRXUSD-UHFFFAOYSA-N

Overview

1,2,3-trichloropropane (CAS 96-18-4) is a chlorinated aliphatic hydrocarbon with significant industrial applications and notable toxicological properties. This colorless liquid compound, also known by its IUPAC name 1,2,3-trichloropropane, belongs to the family of halogenated hydrocarbons and carries the molecular formula C3H5Cl3 with a molecular weight of 147.43 g/mol. The substance is characterized by three chlorine atoms attached to a three-carbon propane backbone, resulting in specific chemical and physical properties that make it valuable for various industrial processes. From a safety perspective, 1,2,3-trichloropropane requires careful handling due to its classification as a Category 1B carcinogen and reproductive toxicant, along with acute toxicity properties. The compound displays GHS pictograms GHS08 and GHS07, indicating serious health hazards, and carries the signal word "Danger." Its ADR classification as Class 6.1 reflects its toxic nature during transportation and storage. These safety characteristics distinguish it from less hazardous chlorinated compounds, though it shares some toxicological concerns with other halogenated substances like chloro(methoxy)methane, which also requires specialized handling protocols. The primary industrial applications of 1,2,3-trichloropropane include its use as a chemical intermediate in organic synthesis, particularly in the production of specialty chemicals and pharmaceutical intermediates. It also serves as a solvent in specific industrial processes and as a building block for various chlorinated derivatives. The compound's unique structure makes it valuable in manufacturing processes where selective chlorination is required. OYSI maintains availability of 1,2,3-trichloropropane for qualified industrial customers, ensuring proper documentation and compliance with European chemical regulations for this controlled substance.

Safety & Classification

Danger
Classification:

Carc. 1B; Repr. 1B; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2810
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Name1,2,3-Trichlorpropan
Marine PollutantNo

Frequently Asked Questions

What is 1,2,3-trichloropropane?

1,2,3-trichloropropane is an organochlorine compound with the chemical formula C3H5Cl3 and CAS number 96-18-4. This chlorinated hydrocarbon has a molecular weight of 147.43 g/mol and belongs to the family of halogenated alkanes. It is classified as a dangerous substance with carcinogenic and reproductive toxicity properties, requiring careful handling and strict safety measures in industrial applications.

What are the physicochemical properties of 1,2,3-trichloropropane?

1,2,3-trichloropropane is a colorless liquid at room temperature with a characteristic sweet odor. It has a boiling point of approximately 157°C and a density higher than water. The compound is moderately soluble in water and miscible with most organic solvents. It exhibits typical properties of chlorinated hydrocarbons, including chemical stability under normal conditions and resistance to hydrolysis.

What is 1,2,3-trichloropropane used for?

1,2,3-trichloropropane is primarily used as a chemical intermediate in organic synthesis and as a solvent in specialized industrial applications. It serves as a precursor for the production of other chemicals and can be found in certain paint strippers and cleaning formulations. Due to its hazardous properties, its use is highly regulated and limited to professional applications with appropriate safety controls.

How to handle 1,2,3-trichloropropane safely?

1,2,3-trichloropropane requires strict safety measures including wearing appropriate personal protective equipment such as chemical-resistant gloves, safety goggles, and respiratory protection. Work must be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Given its carcinogenic and reproductive toxicity classification, minimize skin contact and ensure proper training for all personnel handling this substance.

How to store 1,2,3-trichloropropane correctly?

1,2,3-trichloropropane must be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Use only original containers or approved chemical-resistant containers with proper labeling. Storage areas should be equipped with appropriate spill containment measures and restricted access. Keep away from oxidizing agents and ensure compliance with local regulations for hazardous chemical storage.

What to do in case of contact with 1,2,3-trichloropropane?

In case of skin contact with 1,2,3-trichloropropane, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes and seek medical attention. If inhaled, move the person to fresh air and seek immediate medical attention. In case of ingestion, do not induce vomiting and contact emergency services immediately.

How to dispose of 1,2,3-trichloropropane properly?

1,2,3-trichloropropane must be disposed of as hazardous waste through authorized waste management companies specializing in chemical disposal. The substance cannot be discharged into sewers, soil, or water bodies due to environmental regulations. Disposal must comply with local, national, and EU waste regulations. Small quantities should be collected and stored in appropriate containers until professional disposal can be arranged through certified waste handlers.

How to transport 1,2,3-trichloropropane?

1,2,3-trichloropropane is classified under ADR Class 6.1 (Toxic substances), Packing Group III for transportation purposes. Transport requires appropriate packaging, labeling with GHS07 and GHS08 pictograms, and proper documentation. Vehicles must comply with ADR regulations for toxic substances, including appropriate placarding and driver certification. Ensure packages are properly secured and protected from damage during transit.

Is 1,2,3-trichloropropane subject to special regulations?

1,2,3-trichloropropane is subject to comprehensive regulations under REACH and CLP regulations in Europe due to its carcinogenic (Carc. 1B) and reproductive toxicity (Repr. 1B) classification. Users must comply with authorization requirements, exposure limits, and risk management measures. The substance requires safety data sheets, proper labeling with danger signal word, and adherence to occupational health and safety regulations in all member states.

Where to buy 1,2,3-trichloropropane in Europe?

1,2,3-trichloropropane is available through OYSI, a specialized European distributor of technical chemicals. As an authorized supplier, OYSI ensures compliance with all regulatory requirements and provides proper documentation including safety data sheets and certificates of analysis. Given the restricted nature of this substance, purchases require verification of legitimate use and appropriate handling capabilities by qualified personnel.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.