1-bromo-3,5-difluorobenzene

1-bromo-3,5-difluorobenzene is an organohalogen compound with the molecular formula C6H3BrF2 and CAS number 461-96-1. This aromatic compound features a benzene ring substituted with one bromine atom and two fluorine atoms at specific positions. With a molecular weight of 192.99 g/mol, it serves as an important intermediate in organic synthesis and pharmaceutical manufacturing.

1-bromo-3,5-difluorobenzene is typically a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. As an aromatic halide compound, it exhibits low water solubility but good solubility in organic solvents such as alcohols, ethers, and hydrocarbons. The presence of halogen substituents affects its boiling point and density compared to unsubstituted benzene.

1-bromo-3,5-difluorobenzene is primarily used as a building block in organic synthesis, particularly in pharmaceutical and agrochemical industries. It serves as an intermediate for the synthesis of more complex molecules through cross-coupling reactions, nucleophilic substitutions, and other organic transformations. Its unique substitution pattern makes it valuable for creating specific molecular architectures in drug development and specialty chemical production.

1-bromo-3,5-difluorobenzene requires careful handling due to its classification as Flam. Liq. 3, Acute Tox. 4, and Skin Sens. 1. Wear appropriate PPE including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. Keep away from ignition sources and use non-sparking tools. Avoid skin contact and ensure emergency eyewash stations are accessible.

1-bromo-3,5-difluorobenzene should be stored in tightly closed containers in a cool, dry, well-ventilated area away from heat sources and ignition. Keep containers upright and protected from direct sunlight. Store separately from incompatible materials such as strong oxidizers, bases, and reactive metals. Ensure storage areas are equipped with appropriate fire suppression systems and maintain temperatures below the flash point.

In case of skin contact with 1-bromo-3,5-difluorobenzene, immediately remove contaminated clothing and wash affected area with plenty of soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15-20 minutes and seek medical attention. If inhaled, move to fresh air immediately. If swallowed, do not induce vomiting and seek immediate medical attention. Always consult a physician if symptoms persist.

1-bromo-3,5-difluorobenzene must be disposed of according to local and national hazardous waste regulations due to its environmental classification (Aquatic Acute 1). Contact licensed waste disposal companies for proper treatment and disposal. Do not discharge into drains, soil, or water bodies. Small quantities may be suitable for controlled incineration at appropriate facilities. Always check current regulatory requirements before disposal.

1-bromo-3,5-difluorobenzene is classified as ADR Class 3 (flammable liquids), Packing Group III for transportation purposes. It requires appropriate UN-specification packaging and proper labeling with GHS pictograms including GHS02, GHS07, GHS08, and GHS09. Transport vehicles must comply with ADR regulations for Class 3 substances, and drivers require appropriate training and documentation for hazardous goods transport.

1-bromo-3,5-difluorobenzene is subject to REACH regulation requirements for registration, evaluation, and authorization in the European Union. It is classified under CLP regulation with specific hazard classifications and labeling requirements. The substance is not currently listed as SVHC (Substance of Very High Concern). Users must comply with occupational exposure limits and environmental protection measures according to national and EU legislation.

1-bromo-3,5-difluorobenzene is available through OYSI, a leading European distributor of specialty chemicals and pharmaceutical intermediates. OYSI provides high-quality chemical products with proper documentation, safety data sheets, and regulatory compliance support across Europe. Contact OYSI's technical sales team for availability, specifications, and delivery options to meet your specific requirements for this aromatic halide compound.