1-bromo-3,5-difluorobenzene

1-bromo-3,5-difluorobenzene is an aromatic halogenated compound with the molecular formula C6H3BrF2 and CAS number 461-96-1. This benzene derivative contains one bromine atom and two fluorine atoms positioned at the 1, 3, and 5 positions respectively on the benzene ring. With a molecular weight of 192.99 g/mol, it serves as an important intermediate in organic synthesis and pharmaceutical manufacturing.

1-bromo-3,5-difluorobenzene is typically a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. As a halogenated aromatic compound, it exhibits low water solubility but good solubility in organic solvents such as alcohols, ethers, and hydrocarbons. The presence of both bromine and fluorine substituents influences its reactivity and physical properties, making it relatively stable under normal conditions.

1-bromo-3,5-difluorobenzene is primarily used as an intermediate in organic synthesis, particularly in pharmaceutical and agrochemical manufacturing. It serves as a building block for the synthesis of more complex molecules through various coupling reactions, including Suzuki and Heck reactions. The compound is also utilized in the production of specialty chemicals, dyes, and advanced materials where specific halogen substitution patterns are required.

1-bromo-3,5-difluorobenzene requires careful handling due to its flammable and toxic properties. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. Keep away from ignition sources, heat, and open flames. Avoid skin contact and ensure emergency shower and eyewash stations are accessible during handling operations.

1-bromo-3,5-difluorobenzene should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition points. Keep containers away from incompatible materials such as strong oxidizing agents, bases, and reactive metals. Store in secondary containment to prevent spills and ensure proper labeling according to GHS requirements. Maintain storage temperatures below 25°C and protect from direct sunlight.

In case of skin contact with 1-bromo-3,5-difluorobenzene, immediately remove contaminated clothing and wash affected areas thoroughly with soap and water for at least 15 minutes. If inhaled, move to fresh air immediately and seek medical attention if breathing difficulties occur. For eye contact, flush with clean water for at least 15 minutes and remove contact lenses if present. Seek immediate medical attention for all exposure incidents.

1-bromo-3,5-difluorobenzene must be disposed of as hazardous waste through licensed waste management companies in accordance with local and European regulations. Do not discharge into drains, soil, or water bodies due to its aquatic toxicity classification. Contaminated containers and materials should also be treated as hazardous waste. Consult your local environmental authorities for specific disposal requirements and approved waste treatment facilities.

1-bromo-3,5-difluorobenzene is classified under ADR Class 3 (Flammable Liquids), Packing Group III for transportation. It must be packaged in UN-approved containers with proper hazard labels and documentation. Transport vehicles require appropriate placarding and drivers need ADR certification. Ensure compliance with quantity limitations for different transport categories and maintain proper shipping papers during transit throughout Europe.

1-bromo-3,5-difluorobenzene is subject to REACH regulation requirements for registration, evaluation, and authorization within the European Union. It must comply with CLP regulation for classification, labeling, and packaging as indicated by its GHS pictograms and hazard statements. While not currently listed as an SVHC substance, users must ensure compliance with occupational exposure limits and environmental discharge restrictions in their respective countries.

1-bromo-3,5-difluorobenzene is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical supplier, OYSI provides this compound with proper documentation, safety data sheets, and regulatory compliance certificates. Contact OYSI directly for availability, packaging options, and delivery throughout Europe. Ensure your supplier provides materials meeting your specific purity and quality requirements for your applications.