1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene is a halogenated aromatic compound with the molecular formula C7H2ClF5 and CAS number 77227-99-7. This chemical features a benzene ring substituted with one chlorine atom, two fluorine atoms, and one trifluoromethyl group. With a molecular weight of 216.53 g/mol, it belongs to the class of polyfluorinated aromatic compounds used primarily as chemical intermediates in pharmaceutical and agrochemical synthesis.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene is typically a liquid at room temperature due to its aromatic structure and halogen substitutions. The presence of multiple fluorine atoms significantly affects its polarity and boiling point. As a halogenated aromatic compound, it likely has limited water solubility but good solubility in organic solvents. The trifluoromethyl group contributes to its chemical stability and lipophilicity, making it valuable for synthetic applications.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene serves primarily as a chemical intermediate in organic synthesis, particularly in pharmaceutical and agrochemical manufacturing. Its multiple halogen substitutions make it valuable for cross-coupling reactions and nucleophilic aromatic substitution processes. The compound is used to introduce fluorinated aromatic moieties into target molecules, enhancing their metabolic stability and bioavailability. It may also find applications in materials science for developing specialized polymers or electronic materials.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene requires careful handling due to its flammable and toxic properties (Flam. Liq. 3, Acute Tox. 4). Use appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. Keep away from heat sources, sparks, and open flames. Ensure emergency eyewash and shower facilities are accessible, and have spill cleanup materials readily available.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene should be stored in a cool, dry, well-ventilated area away from heat sources and ignition sources due to its flammable nature (Class 3). Use appropriate secondary containment and ensure containers are tightly sealed to prevent vapor release. Store separately from oxidizing agents, strong bases, and incompatible materials. Maintain storage temperature below 25°C when possible and protect from direct sunlight. Regularly inspect containers for leaks or deterioration.

Immediate action is required upon contact with 1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene due to its acute toxicity. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water. In case of eye contact, rinse immediately with plenty of clean water for at least 15 minutes. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after exposure incidents.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene must be disposed of through licensed hazardous waste disposal facilities due to its environmental hazard classification (Aquatic Acute 1). Do not discharge into drains, sewers, or water bodies. Collect waste in appropriate containers labeled for halogenated organic solvents. Contact certified waste disposal companies familiar with fluorinated compounds. Follow local and national regulations for hazardous waste management, including proper documentation and tracking requirements for disposal.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene is classified as ADR Class 3 (flammable liquid), Packing Group III for transportation purposes. Use UN-approved packaging suitable for flammable liquids with appropriate hazard labels and markings. Transport documents must include proper shipping names and emergency response information. Vehicles must comply with ADR requirements for Class 3 substances, including proper ventilation and fire prevention measures. Avoid transport during extreme temperatures and ensure drivers are trained in hazardous materials handling.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene is subject to standard chemical regulations including REACH registration requirements in Europe and CLP classification (GHS02, GHS07, GHS09 pictograms). It is not currently listed as a Substance of Very High Concern (SVHC). Manufacturers and importers must comply with safety data sheet requirements and downstream user obligations. The substance may be subject to workplace exposure limits and environmental discharge restrictions depending on national legislation in individual EU member states.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene is available through OYSI, a specialized European distributor of chemical products. OYSI provides reliable supply chains for industrial and research applications across Europe, ensuring compliance with REACH and transportation regulations. As a professional chemical distributor, OYSI offers technical support, proper documentation, and quality assurance for this specialty fluorinated compound. Contact OYSI directly for availability, specifications, and delivery options to your location within Europe.