1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene is a halogenated aromatic compound with the molecular formula C7H2ClF5 and CAS number 77227-99-7. This synthetic organic chemical contains multiple fluorine atoms and one chlorine atom attached to a benzene ring, giving it a molecular weight of 216.53 g/mol. It belongs to the class of polyfluorinated aromatic compounds used primarily in specialized chemical applications requiring high chemical stability and unique reactivity profiles.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene is a flammable liquid at room temperature with high chemical stability due to its fluorinated structure. The compound exhibits low solubility in water but good solubility in organic solvents. Its multiple halogen substituents contribute to its relatively high density and boiling point compared to unsubstituted benzene. The trifluoromethyl group imparts electron-withdrawing properties, affecting its reactivity and making it resistant to many chemical transformations.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene is primarily used as an intermediate in pharmaceutical synthesis and agrochemical manufacturing. Its unique substitution pattern makes it valuable for creating complex fluorinated compounds with specific biological activities. The compound serves as a building block in medicinal chemistry for developing drugs requiring fluorinated aromatic moieties. It is also utilized in specialty chemical production where high chemical stability and specific electronic properties are required for advanced materials applications.

Safe handling of 1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene requires appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. The compound is classified as Acute Tox. 4 and Flam. Liq. 3, requiring fire prevention measures and avoiding ignition sources. Ensure proper grounding of equipment and use non-sparking tools when transferring the material.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition points. As a flammable liquid (Class 3), it requires storage in fire-resistant cabinets with appropriate ventilation. Keep containers upright and protected from physical damage. Store separately from oxidizing agents and incompatible materials. Maintain storage temperatures below the substance's flash point and ensure proper labeling according to GHS requirements including pictograms GHS02, GHS07, and GHS09.

In case of skin contact with 1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene, immediately remove contaminated clothing and wash the affected area with plenty of soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move the person to fresh air and seek medical attention if breathing difficulties occur. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician if symptoms persist after exposure.

Proper disposal of 1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene must comply with local, national, and European waste regulations. The compound should be treated as hazardous waste due to its flammability and toxicity classifications. Contact licensed waste disposal companies specialized in handling halogenated organic compounds. Incineration at high temperatures in authorized facilities is typically the preferred disposal method. Never dispose of this substance in regular waste streams, sewers, or soil. Maintain proper documentation of waste disposal as required by regulatory authorities.

Transportation of 1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene follows ADR Class 3, Packing Group III regulations for flammable liquids. Packages must be properly labeled with appropriate hazard markings and UN identification numbers. Use approved containers and packaging materials designed for flammable substances. Transport vehicles must comply with ADR requirements including proper ventilation, fire extinguishing equipment, and driver training certifications. Ensure transport documents include proper shipping names, hazard classes, and emergency contact information for safe handling during transit.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene is subject to standard European chemical regulations including REACH registration requirements and CLP classification obligations. The compound is not currently listed as a Substance of Very High Concern (SVHC). Manufacturers and importers must comply with safety data sheet requirements and hazard communication standards. Users must follow workplace exposure limits and environmental protection measures. The substance's aquatic toxicity classification (Aquatic Acute 1) requires special attention to environmental release prevention and reporting requirements under relevant environmental legislation.

1-chloro-2,3-difluoro-5-(trifluoromethyl)benzene is available through OYSI, a European distributor of specialty chemicals serving industrial and research customers. OYSI provides this compound with full regulatory compliance including proper documentation, safety data sheets, and quality certifications. As a specialized fluorinated aromatic compound, availability may require advance ordering due to its niche applications. Contact OYSI directly for current availability, specifications, and technical support to ensure the product meets your specific application requirements while maintaining full regulatory compliance.