Tetramethylplumbane

C4H12Pb

tetramethylplumbane

CAS75-74-1
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
75-74-1
EC Number
200-897-0
UN Number
3483
Index Number
082-002-00-1
PubChem CID
6394

Physical-chemical properties

Molecular Formula
C4H12Pb
Molar Mass
267.00 g/mol
IUPAC Name
tetramethylplumbane

Chemical Identifiers

InChI
InChI=1S/4CH3.Pb/h4*1H3;
InChI Key
XOOGZRUBTYCLHG-UHFFFAOYSA-N

Overview

Tetramethylplumbane (CAS 75-74-1) is an organometallic compound with highly toxic properties and significant environmental hazards. This organolead compound, with the molecular formula C4H12Pb and a molecular weight of 267 g/mol, represents one of the most hazardous substances in industrial chemistry. Tetramethylplumbane belongs to the family of alkyllead compounds that were historically significant in the petroleum industry but are now strictly regulated due to their severe health and environmental implications. The compound exhibits extreme toxicity across multiple exposure routes, classified under GHS with danger pictograms including skull and crossbones (GHS06), health hazard (GHS08), and environmental hazard (GHS09). Its classification as Reproductive Category 1A indicates proven reproductive toxicity, while its Acute Toxicity Category 1 and 2 classifications across different exposure pathways underscore the immediate life-threatening risks. The compound also presents significant chronic health risks with STOT RE 2 classification, indicating potential organ damage following repeated exposure. From an environmental perspective, tetramethylplumbane poses acute and chronic aquatic toxicity, requiring careful containment and disposal protocols. Unlike less hazardous industrial chemicals such as N-methylaniline, tetramethylplumbane demands the highest level of safety precautions during handling and storage. Industrial applications remain extremely limited due to regulatory restrictions, though the compound may be used in specialized research applications and as a reference standard in analytical chemistry. Some applications exist in the synthesis of other organometallic compounds under strictly controlled laboratory conditions. OYSI maintains availability of tetramethylplumbane for qualified customers with appropriate safety infrastructure and regulatory compliance capabilities.

Safety & Classification

Danger
Classification:

Repr. 1A; Acute Tox. 2 *; Acute Tox. 1; Acute Tox. 2 *; STOT RE 2 *; Aquatic Acute 1; Aquatic Chr...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H330

Fatal if inhaled.

H310

Fatal in contact with skin.

H300

Fatal if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Fatal

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Fatal

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Fatal

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3483
ADR Class6.1
Packing GroupI
Tunnel CodeC/D
Proper Shipping NameTetramethylblei
Marine PollutantNo

Frequently Asked Questions

What is tetramethylplumbane?

Tetramethylplumbane is an organolead compound with the molecular formula C4H12Pb and CAS number 75-74-1. This chemical substance has a molecular weight of 267 g/mol and belongs to the family of tetraalkylplumbanes. It is classified as an extremely hazardous material with multiple health and environmental risks, including reproductive toxicity, acute toxicity, and aquatic toxicity. Due to its lead content, it poses severe health risks and requires specialized handling procedures.

What are the physicochemical properties of tetramethylplumbane?

Tetramethylplumbane is an organometallic compound that typically exists as a colorless liquid at room temperature. As a lead-containing organic compound, it exhibits high volatility and can readily evaporate. The substance has limited solubility in water but is generally soluble in organic solvents. Its molecular structure consists of a central lead atom bonded to four methyl groups, giving it its characteristic properties and high toxicity profile.

What is tetramethylplumbane used for?

Tetramethylplumbane serves primarily as a specialized reagent in advanced chemical synthesis and research applications. It may be used in organometallic chemistry for specific reactions requiring lead-containing compounds. However, due to its extreme toxicity and environmental hazards, its applications are highly restricted and limited to specialized industrial processes under strict safety controls. Most commercial uses have been phased out due to health and environmental concerns.

How to handle tetramethylplumbane safely?

Tetramethylplumbane requires maximum safety precautions during handling due to its extreme toxicity. Personnel must wear full protective equipment including chemical-resistant gloves, protective clothing, and respiratory protection. Work should only be conducted in well-ventilated areas or fume hoods. Avoid all contact with skin, eyes, and inhalation of vapors. Only trained personnel should handle this substance, and emergency procedures must be readily available.

How to store tetramethylplumbane correctly?

Tetramethylplumbane must be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. The storage area should be secured and accessible only to authorized personnel. Containers must be properly sealed and labeled according to GHS requirements with appropriate danger pictogrammes (GHS06, GHS08, GHS09). Storage facilities should have appropriate spill containment measures and emergency response equipment readily available.

What to do in case of contact with tetramethylplumbane?

Tetramethylplumbane exposure requires immediate emergency action. In case of skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water. For eye contact, flush immediately with water for at least 15 minutes. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting. Seek immediate medical attention in all cases of exposure and provide the safety data sheet to medical personnel.

How to dispose of tetramethylplumbane appropriately?

Tetramethylplumbane disposal must comply with strict hazardous waste regulations due to its lead content and extreme toxicity. The substance cannot be disposed of through normal waste streams and requires specialized hazardous waste treatment. Disposal must be performed by licensed hazardous waste contractors following local and European waste regulations. Empty containers should also be treated as hazardous waste and disposed of through appropriate channels.

How to transport tetramethylplumbane?

Tetramethylplumbane is classified under ADR Class 6.1 (Toxic substances), Packing Group I, indicating its extreme toxicity. Transportation requires specialized packaging meeting UN specifications and proper hazardous goods documentation. Vehicles must display appropriate hazard placards and emergency information. Only trained drivers with hazardous materials certification can transport this substance. Emergency response procedures must be available during transport.

Is tetramethylplumbane subject to specific regulations?

Tetramethylplumbane is subject to extensive regulatory control under European legislation including REACH and CLP regulations. Its classification as Repr. 1A, Acute Tox. 1-2, STOT RE 2, and aquatic toxicity categories places it under strict regulatory oversight. The substance may be subject to authorization requirements, use restrictions, and mandatory risk management measures. Companies must comply with registration, notification, and safety data sheet requirements.

Where to buy tetramethylplumbane in Europe?

Tetramethylplumbane is available through OYSI, a specialized European distributor of technical chemicals. As a highly regulated substance with extreme toxicity, procurement requires proper authorization and compliance with regulatory requirements. OYSI ensures full regulatory compliance and provides appropriate documentation for legal purchase and use. Customers must demonstrate legitimate use and proper safety measures before procurement can be authorized.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.