Sodium 2-chloroacetate
C2H2ClNaO2
sodium 2-chloroacetate
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Identification
- CAS Number
- 3926-62-3
- EC Number
- 223-498-3
- UN Number
- 2659
- Index Number
- 607-158-00-5
- PubChem CID
- 23665759
Physical-chemical properties
- Molecular Formula
- C2H2ClNaO2
- Molar Mass
- 116.48 g/mol
- IUPAC Name
- sodium 2-chloroacetate
Chemical Identifiers
- InChI
- InChI=1S/C2H3ClO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1
- InChI Key
- FDRCDNZGSXJAFP-UHFFFAOYSA-M
Overview
Sodium 2-chloroacetate (CAS 3926-62-3) is an organochlorine sodium salt with high reactivity and significant toxicity properties. This white crystalline compound serves as a versatile intermediate in organic synthesis and industrial chemical processes. With the molecular formula C2H2ClNaO2 and a molecular weight of 116.48 g/mol, sodium 2-chloroacetate belongs to the family of haloacetic acid derivatives that play crucial roles in pharmaceutical and agrochemical manufacturing. The presence of both chlorine and carboxylate functional groups makes this compound particularly valuable for nucleophilic substitution reactions and as a building block for more complex molecular structures. From a safety perspective, sodium 2-chloroacetate requires careful handling due to its classification as Acute Toxicity Category 3 with acute aquatic toxicity properties. The compound displays the GHS06 skull and crossbones pictogram alongside GHS09 environmental hazard symbol, reflecting its potential dangers to both human health and aquatic ecosystems. Its ADR Class 6.1 classification necessitates specialized transport and storage protocols to ensure workplace safety and environmental protection. Industrial applications of sodium 2-chloroacetate include pharmaceutical synthesis, where it serves as an alkylating agent for producing various therapeutic compounds. The chemical industry also utilizes this compound in agrochemical manufacturing and as a precursor for specialty chemicals. Unlike compounds such as N-methylaniline or phenylhydrazine which serve different synthetic purposes, sodium 2-chloroacetate's unique reactivity profile makes it particularly suitable for introducing chloroacetate moieties into target molecules. OYSI provides reliable access to high-quality sodium 2-chloroacetate for European industrial customers requiring this specialized chemical intermediate.
Safety & Classification
Acute Tox. 3 *; Skin Irrit. 2; Aquatic Acute 1
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 2659 |
| ADR Class | 6.1 |
| Packing Group | III |
| Tunnel Code | E |
| Proper Shipping Name | Natriumchloracetat |
| Marine Pollutant | No |
Frequently Asked Questions
What is sodium 2-chloroacetate?
Sodium 2-chloroacetate is an organochlorine compound with the molecular formula C2H2ClNaO2 and CAS number 3926-62-3. This chemical compound has a molecular weight of 116.48 g/mol and appears as a white crystalline solid. It is classified as a hazardous substance with acute toxicity properties and skin irritation potential. The compound is widely used in various industrial applications and requires careful handling due to its toxic nature and environmental impact on aquatic organisms.
What are the physicochemical properties of sodium 2-chloroacetate?
Sodium 2-chloroacetate is a white crystalline solid at room temperature with good water solubility due to its ionic nature. The compound is hygroscopic, meaning it readily absorbs moisture from the air. It has a molecular weight of 116.48 g/mol and contains a chlorine substituent on the acetate group. The substance is stable under normal conditions but should be protected from moisture and incompatible materials to maintain its integrity and prevent decomposition.
What is sodium 2-chloroacetate used for?
Sodium 2-chloroacetate serves as an important intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of various chemicals including herbicides, pharmaceuticals, and specialty chemicals. The compound acts as an alkylating agent in chemical reactions and is utilized in research laboratories for biochemical studies. Its reactive chloroacetate group makes it valuable for introducing carboxymethyl groups into organic molecules and for synthesizing complex chemical structures.
How to handle sodium 2-chloroacetate safely?
Sodium 2-chloroacetate requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid direct skin and eye contact as the substance causes skin irritation and has acute toxicity properties. Always wash hands thoroughly after handling and ensure emergency eyewash and shower facilities are readily accessible in work areas.
How to store sodium 2-chloroacetate correctly?
Sodium 2-chloroacetate should be stored in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizing agents and reducing agents. Keep containers tightly closed and protected from moisture due to its hygroscopic nature. Store away from heat sources and direct sunlight in appropriate chemical storage areas with secondary containment. Ensure storage areas are equipped with appropriate spill control measures and that containers are properly labeled according to GHS requirements.
What to do in case of contact with sodium 2-chloroacetate?
In case of skin contact with sodium 2-chloroacetate, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with plenty of clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and seek medical advice if symptoms persist. In case of ingestion, do not induce vomiting and seek immediate medical attention while providing the safety data sheet to medical personnel.
How to dispose of sodium 2-chloroacetate appropriately?
Sodium 2-chloroacetate must be disposed of as hazardous waste through licensed waste disposal contractors in accordance with local, national, and EU regulations. The substance cannot be disposed of in regular waste streams due to its toxic properties and environmental impact on aquatic organisms. Contact certified hazardous waste disposal companies for proper treatment and disposal. Ensure proper documentation and tracking of waste disposal activities, and never discharge the substance into sewers, waterways, or soil.
How to transport sodium 2-chloroacetate?
Sodium 2-chloroacetate is classified under ADR Class 6.1 (Toxic substances) Packing Group III for transportation purposes. The substance requires appropriate UN-specification packaging and proper labeling with GHS06 and GHS09 pictograms during transport. Vehicles must carry appropriate emergency response information and drivers need proper hazmat training. Ensure compliance with ADR regulations for toxic substances and follow proper loading, segregation, and documentation requirements throughout the transportation process.
Is sodium 2-chloroacetate subject to specific regulations?
Sodium 2-chloroacetate is subject to various European regulations including REACH registration requirements and CLP classification and labeling obligations. The substance is classified with hazard statements for acute toxicity, skin irritation, and aquatic environmental hazards. While not currently listed as a SVHC (Substance of Very High Concern), it must comply with standard chemical safety regulations. Users must maintain safety data sheets, conduct appropriate risk assessments, and implement necessary risk management measures according to EU chemical legislation.
Where to buy sodium 2-chloroacetate in Europe?
Sodium 2-chloroacetate is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. OYSI provides high-quality chemical products with proper documentation including certificates of analysis and safety data sheets. As a reliable supplier, OYSI ensures compliance with European regulations and offers technical support for customers requiring sodium 2-chloroacetate for their industrial processes, research applications, or chemical synthesis needs.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.