Pentanoic acid

C5H10O2

pentanoic acid

CAS109-52-4
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
109-52-4
EC Number
203-677-2
UN Number
3265
Index Number
607-143-00-3
PubChem CID
7991

Physical-chemical properties

Molecular Formula
C5H10O2
Molar Mass
102.13 g/mol
IUPAC Name
pentanoic acid

Chemical Identifiers

InChI
InChI=1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)
InChI Key
NQPDZGIKBAWPEJ-UHFFFAOYSA-N

Overview

Pentanoic acid (CAS 109-52-4) is a saturated carboxylic acid with five carbon atoms, characterized by its corrosive properties and distinctive odor. This straight-chain monocarboxylic acid, also known as valeric acid, represents an important intermediate in organic chemistry and industrial applications. With the molecular formula C5H10O2 and a molecular weight of 102.13 g/mol, pentanoic acid exhibits typical properties of medium-chain fatty acids. The compound appears as a colorless to pale yellow liquid with a sharp, unpleasant odor reminiscent of sweaty feet or rancid cheese, making proper ventilation essential during handling. Safety considerations are paramount when working with pentanoic acid, as it is classified as Skin Corr. 1B under GHS regulations, indicating severe skin burns and eye damage upon contact. The substance carries the danger signal word and requires the corrosive pictogram (GHS05). Additionally, its Aquatic Chronic 3 classification necessitates careful environmental handling to prevent water contamination. Transportation falls under ADR Class 8 (corrosive substances), requiring appropriate packaging and labeling protocols. In industrial applications, pentanoic acid serves as a key building block for synthesizing esters used in flavoring and fragrance industries, where its derivatives provide fruity and cheese-like notes. The pharmaceutical sector utilizes pentanoic acid in the production of various drug intermediates and active compounds. Unlike more aggressive chemicals such as tetrachlorostannane or trichlorostibane, pentanoic acid offers a more manageable profile for organic synthesis applications while maintaining excellent reactivity for esterification and amidation reactions. OYSI maintains reliable supplies of high-quality pentanoic acid to support diverse European industrial requirements across multiple sectors.

Safety & Classification

Danger
Classification:

Skin Corr. 1B; Aquatic Chronic 3

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H314

Causes severe skin burns and eye damage.

H412

Harmful to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3265
ADR Class8
Packing GroupIII
Tunnel CodeE
Proper Shipping NamePentansäure
Marine PollutantNo

Frequently Asked Questions

What is pentanoic acid?

Pentanoic acid is a saturated carboxylic acid with the molecular formula C5H10O2 and CAS number 109-52-4. It belongs to the family of straight-chain fatty acids, consisting of a five-carbon chain with a carboxyl functional group. With a molecular weight of 102.13 g/mol, this organic compound is classified as a skin corrosive substance (Skin Corr. 1B) and poses aquatic chronic toxicity (Aquatic Chronic 3). It requires careful handling due to its corrosive properties and is regulated under chemical safety legislation.

What are the physicochemical properties of pentanoic acid?

Pentanoic acid is a colorless liquid at room temperature with a characteristic pungent, rancid odor reminiscent of goat or cheese. It has a boiling point of approximately 186°C and is moderately soluble in water, with solubility decreasing compared to shorter-chain carboxylic acids. The compound is miscible with most organic solvents including alcohols and ethers. Its density is around 0.94 g/cm³, and it exhibits typical carboxylic acid properties such as forming hydrogen bonds and showing acidic behavior in aqueous solutions.

What is pentanoic acid used for?

Pentanoic acid is primarily used as an intermediate in chemical synthesis and pharmaceutical manufacturing. It serves as a building block for the production of esters, which are utilized in flavoring and fragrance industries due to its distinctive odor profile. The compound finds applications in the synthesis of pentanoate salts and derivatives used in various industrial processes. Additionally, it is employed in research and development activities, particularly in organic chemistry laboratories for synthetic pathway development and as a reagent in specialized chemical reactions.

How to handle pentanoic acid safely?

Pentanoic acid requires strict safety measures due to its skin corrosive classification (1B). Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation of vapors. Handle containers carefully to prevent spills, and ensure emergency eyewash stations and safety showers are readily accessible. Always use appropriate tools for transfer operations and avoid direct contact with the substance at all costs.

How to store pentanoic acid correctly?

Pentanoic acid should be stored in tightly sealed, corrosion-resistant containers in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. Keep containers upright and ensure secondary containment to prevent environmental contamination. Store away from incompatible materials such as strong bases, oxidizing agents, and reactive metals. Maintain storage temperatures below 25°C when possible, and regularly inspect containers for signs of corrosion or leakage. Access should be restricted to authorized personnel only, with appropriate safety equipment nearby.

What to do in case of contact with pentanoic acid?

Pentanoic acid contact requires immediate emergency response due to its corrosive nature. For skin contact, immediately remove contaminated clothing and flush the affected area with copious amounts of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water for at least 15 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. Seek immediate medical attention for all exposure routes, as this substance can cause severe chemical burns and tissue damage. Do not attempt to neutralize with other chemicals.

How to dispose of pentanoic acid appropriately?

Pentanoic acid disposal must comply with local and European waste regulations as it is classified as hazardous waste. The substance cannot be disposed of in regular waste streams or poured down drains due to its corrosive properties and aquatic toxicity. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small laboratory quantities may be neutralized under controlled conditions by qualified personnel before disposal, but this should only be done following established protocols. Always consult local environmental authorities for specific disposal requirements and approved facilities.

How to transport pentanoic acid?

Pentanoic acid is classified under ADR Class 8 (corrosive substances), Packing Group III for transportation purposes. This classification requires specific packaging, labeling, and documentation for road transport within Europe. Packages must display the appropriate hazard labels including the GHS05 corrosion pictogram and 'Danger' signal word. Transport vehicles must carry appropriate emergency equipment and documentation. Drivers require ADR training for handling corrosive materials. Ensure compliance with all applicable transport regulations and use approved packaging that meets UN specifications for Class 8 substances.

Is pentanoic acid subject to specific regulations?

Pentanoic acid is subject to European chemical regulations including REACH and CLP classifications. Under CLP, it is classified as Skin Corr. 1B and Aquatic Chronic 3, requiring appropriate labeling with GHS05 pictogram and 'Danger' signal word. It is not currently listed as a Substance of Very High Concern (SVHC). Users must comply with safety data sheet requirements, workplace exposure limits, and proper risk assessment procedures. Additional sector-specific regulations may apply depending on the intended use, particularly in pharmaceutical or food-related applications where stricter controls might be required.

Where to buy pentanoic acid in Europe?

Pentanoic acid is available through OYSI, a specialized European distributor of technical chemicals serving industrial and professional customers across Europe. OYSI provides high-quality pentanoic acid with proper documentation, safety data sheets, and regulatory compliance support. As a professional chemical distributor, OYSI ensures proper handling, packaging, and delivery of corrosive substances like pentanoic acid. Contact OYSI directly for specific grade requirements, quantities, and delivery options to your European location. Professional customers can rely on OYSI's expertise in chemical distribution and regulatory compliance.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.