N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine

C8H14N2S

CAS154212-60-9
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
154212-60-9
EC Number
414-800-6
UN Number
3082
Index Number
612-192-00-9
PubChem CID
10749687

Physical-chemical properties

Molecular Formula
C8H14N2S
Molar Mass
170.28 g/mol
IUPAC Name
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine

Chemical Identifiers

InChI
InChI=1S/C8H14N2S/c1-6(2)8-10-7(4-9-3)5-11-8/h5-6,9H,4H2,1-3H3
InChI Key
HWSFABGWAXURNG-UHFFFAOYSA-N

Overview

N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine (CAS 154212-60-9) is a thiazole-containing organic compound with secondary amine functionality and isopropyl substitution. This specialized chemical intermediate belongs to the thiazole family, featuring a five-membered heterocyclic ring containing both sulfur and nitrogen atoms. With the molecular formula C8H14N2S and a molecular weight of 170.28 g/mol, this compound exhibits unique structural characteristics that make it valuable for various synthetic applications. The presence of both the thiazole ring system and the N-methyl aminomethyl side chain provides multiple reactive sites for chemical transformations. The compound presents significant safety considerations, classified under multiple hazard categories including acute toxicity (Category 4), skin irritation (Category 2), serious eye damage (Category 1), and chronic aquatic toxicity (Category 2). The GHS pictograms GHS07, GHS05, and GHS09 indicate health hazards, corrosive properties, and environmental concerns respectively. Its ADR classification as Class 9 identifies it as a miscellaneous dangerous substance requiring careful handling protocols during transportation and storage. In industrial applications, N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine serves primarily as a pharmaceutical intermediate in drug discovery and development processes. The compound finds additional use in agrochemical synthesis and specialty chemical manufacturing. Its structural similarity to other complex intermediates like 3-amino-4-hydroxy-N-(3-propan-2-yloxypropyl)benzenesulfonamide hydrochloride highlights its relevance in pharmaceutical chemistry applications. OYSI maintains reliable supply chains for this specialized chemical intermediate, ensuring consistent availability for European industrial customers requiring high-quality thiazole derivatives for their synthetic programs.

Safety & Classification

Danger
Classification:

Acute Tox. 4 *; Acute Tox. 4 *; Skin Irrit. 2; Eye Dam. 1; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H315

Causes skin irritation.

H318

Causes serious eye damage.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3082
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name2-Isopropyl-4-(N-methyl)aminomethylthiazol
Marine PollutantNo

Frequently Asked Questions

What is N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine?

N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is an organic chemical compound with the molecular formula C8H14N2S and a molecular weight of 170.28 g/mol. This thiazole-containing amine derivative is identified by CAS number 154212-60-9. The compound features a thiazole ring structure with an isopropyl substituent and a methylated aminomethyl side chain, making it a specialized chemical intermediate used in various synthetic applications.

What are the physicochemical properties of N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine?

N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is a sulfur and nitrogen-containing organic compound with a molecular weight of 170.28 g/mol. As a substituted thiazole amine, it likely exists as a liquid or low-melting solid at room temperature. The presence of both polar amine groups and the aromatic thiazole ring suggests moderate polarity, potentially affecting its solubility in various solvents. Specific physical properties should be confirmed through technical data sheets.

What is N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine used for?

N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is primarily used as a chemical intermediate in pharmaceutical and fine chemical synthesis. Its thiazole structure and amine functionality make it valuable for developing bioactive compounds, particularly in medicinal chemistry applications. The compound may serve as a building block for synthesizing more complex molecules, including potential pharmaceutical active ingredients, agrochemicals, or specialty chemicals requiring thiazole-containing structures.

How to handle N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine safely?

N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine requires careful handling due to its classification as Acute Tox. 4, Skin Irrit. 2, and Eye Dam. 1. Essential protective equipment includes chemical-resistant gloves, safety goggles or face shield, and appropriate respiratory protection. Work in well-ventilated areas or under fume extraction. Avoid skin and eye contact, and prevent inhalation. Emergency eyewash and shower facilities should be readily accessible when working with this substance.

How to store N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine correctly?

N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Due to its amine functionality, keep away from strong acids and oxidizing agents. Store separately from incompatible materials and ensure containers are properly labeled. Access should be restricted to trained personnel, and storage areas should comply with local chemical storage regulations and fire safety requirements.

What to do in case of contact with N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine?

Immediate action is required for contact with N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine due to its eye damage and skin irritation potential. For eye contact, immediately flush with water for at least 15 minutes and seek medical attention. For skin contact, wash thoroughly with soap and water. If inhaled, move to fresh air. Remove contaminated clothing. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet for complete emergency procedures.

How to dispose of N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine appropriately?

N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine must be disposed of through authorized hazardous waste disposal services in accordance with local, national, and EU regulations. The substance cannot be disposed of via regular waste streams due to its hazardous classification and environmental concerns (Aquatic Chronic 2). Contact licensed waste management companies specializing in chemical disposal. Ensure proper waste classification, packaging, and documentation. Never discharge to sewers, waterways, or soil.

How to transport N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine?

N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is classified as ADR Class 9 (Miscellaneous Dangerous Substances), Packing Group III for transportation. This requires appropriate UN-specification packaging, proper labeling with Class 9 hazard labels, and transport documentation including shipping papers. Vehicles must carry appropriate emergency equipment. Drivers need ADR training certification. The relatively lower risk Packing Group III classification allows for less restrictive transport requirements compared to higher hazard classes.

Is N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine subject to specific regulations?

N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is subject to EU REACH and CLP regulations but is not currently classified as a Substance of Very High Concern (SVHC). Under CLP, it must be classified and labeled according to its hazard classes (Acute Tox. 4, Skin Irrit. 2, Eye Dam. 1, Aquatic Chronic 2). REACH registration requirements may apply depending on import/manufacture volumes. Users must ensure compliance with occupational exposure limits and environmental protection standards.

Where to buy N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine in Europe?

N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides reliable supply chains for research institutions, pharmaceutical companies, and chemical manufacturers across Europe. Their expertise in handling specialized organic compounds ensures proper storage, documentation, and regulatory compliance. Contact OYSI directly for availability, specifications, and technical support for your specific application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.