N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine
C8H14N2S
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Identification
- CAS Number
- 154212-60-9
- EC Number
- 414-800-6
- UN Number
- 3082
- Index Number
- 612-192-00-9
- PubChem CID
- 10749687
Physical-chemical properties
- Molecular Formula
- C8H14N2S
- Molar Mass
- 170.28 g/mol
- IUPAC Name
- N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine
Chemical Identifiers
- InChI
- InChI=1S/C8H14N2S/c1-6(2)8-10-7(4-9-3)5-11-8/h5-6,9H,4H2,1-3H3
- InChI Key
- HWSFABGWAXURNG-UHFFFAOYSA-N
Overview
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine (CAS 154212-60-9) is a thiazole-based organic compound featuring a methylamine functional group and isopropyl substitution. This specialized chemical intermediate belongs to the thiazole family of heterocyclic compounds, characterized by its five-membered ring containing both sulfur and nitrogen atoms. The molecular structure incorporates a methylamine side chain attached to the thiazole ring system, along with an isopropyl group at the 2-position, resulting in the molecular formula C8H14N2S and a molecular weight of 170.28 g/mol. The compound's unique structural features make it valuable for pharmaceutical synthesis and specialty chemical applications. The substance presents several safety considerations requiring careful handling protocols. Classified under multiple acute toxicity categories (Acute Tox. 4), it can cause harmful effects through various exposure routes. The compound exhibits skin irritation properties (Skin Irrit. 2) and severe eye damage potential (Eye Dam. 1), necessitating appropriate personal protective equipment during handling. Its aquatic chronic toxicity classification (Aquatic Chronic 2) indicates environmental persistence concerns, requiring controlled disposal methods. The ADR Class 9 designation reflects its miscellaneous dangerous goods classification for transportation purposes. Industrial applications typically focus on pharmaceutical intermediate synthesis, where the thiazole scaffold serves as a building block for bioactive compounds. The compound also finds use in agrochemical development and specialty organic synthesis. Unlike simpler compounds such as methyl(triphenyl)phosphanium chloride, this thiazole derivative offers specific structural features that enable targeted synthetic transformations in complex molecule construction. OYSI maintains reliable supply chains for N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine, supporting European industrial customers with consistent quality and regulatory compliance throughout our distribution network.
Safety & Classification
Acute Tox. 4 *; Acute Tox. 4 *; Skin Irrit. 2; Eye Dam. 1; Aquatic Chronic 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Skin Contact
Measures if substance contacts the skin
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 3082 |
| ADR Class | 9 |
| Packing Group | III |
| Tunnel Code | - |
| Proper Shipping Name | 2-Isopropyl-4-(N-methyl)aminomethylthiazol |
| Marine Pollutant | No |
Frequently Asked Questions
What is N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine?
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is an organic chemical compound with the molecular formula C8H14N2S and CAS number 154212-60-9. This thiazole derivative has a molecular weight of 170.28 g/mol and contains both nitrogen and sulfur heteroatoms in its structure. The compound features a methylated amine group attached to a thiazole ring system with an isopropyl substituent, making it a specialized chemical intermediate used in various synthetic applications.
What are the physicochemical properties of N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine?
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is a chemical compound with a molecular weight of 170.28 g/mol and molecular formula C8H14N2S. As a substituted thiazole derivative containing both amine and sulfur functionalities, it likely exhibits basic properties due to the nitrogen atoms. The compound's physical state, solubility, and other specific properties would depend on temperature and environmental conditions, requiring consultation of detailed technical datasheets for precise specifications.
What is N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine used for?
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is primarily used as a chemical intermediate in pharmaceutical and fine chemical synthesis. The thiazole ring system and amine functionality make it valuable for developing biologically active compounds and pharmaceutical ingredients. It may also serve as a building block in agrochemical synthesis and specialty chemical manufacturing, where its unique structural features contribute to the development of target molecules with specific biological or chemical properties.
How to handle N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine safely?
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine requires careful handling due to its classification as Acute Tox. 4, Skin Irrit. 2, and Eye Dam. 1. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work in well-ventilated areas or under fume hoods to avoid inhalation. Handle with care to prevent eye contact, which can cause serious damage. Always follow proper laboratory procedures and have emergency eyewash stations readily available.
How to store N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine correctly?
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed to prevent contamination and minimize exposure to air and moisture. Store separately from strong oxidizing agents and acids due to the amine functionality. The storage area should be equipped with appropriate spill containment measures and restricted access. Regular inspection of containers for integrity is recommended to prevent leaks or deterioration.
What to do in case of contact with N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine?
In case of eye contact with N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine, immediately flush with copious amounts of water for at least 15 minutes and seek immediate medical attention due to its Eye Dam. 1 classification. For skin contact, wash thoroughly with soap and water to prevent irritation. If inhaled, move to fresh air immediately. Remove contaminated clothing and wash before reuse. In case of ingestion, do not induce vomiting and seek medical attention promptly. Always consult safety data sheets for complete first aid procedures.
How to dispose of N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine appropriately?
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine must be disposed of according to local, national, and international waste regulations due to its hazard classification and environmental impact (Aquatic Chronic 2). Do not discharge into drains, waterways, or the environment. Contact licensed waste disposal companies specialized in hazardous chemical waste. Small quantities may require incineration at authorized facilities with appropriate emission controls. Always consult current waste classification codes and regulations in your jurisdiction before disposal.
How to transport N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine?
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is classified under ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation. This classification requires appropriate packaging, labeling, and documentation according to ADR regulations. Use UN-specification packaging suitable for Class 9 materials and ensure proper hazard labels (GHS07, GHS05, GHS09) are affixed. Transport vehicles must comply with ADR requirements for Class 9 substances, and drivers need appropriate training certificates. Consult current ADR regulations for complete transport requirements.
Is N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine subject to special regulations?
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is subject to standard European chemical regulations under REACH and CLP, but is not classified as a Substance of Very High Concern (SVHC). It must comply with classification, labeling, and packaging requirements showing GHS pictograms (GHS07, GHS05, GHS09) and the signal word 'Danger'. Suppliers must provide safety data sheets and ensure proper registration under REACH if manufactured or imported above threshold quantities. Users must follow occupational exposure regulations and waste disposal requirements.
Where to buy N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine in Europe?
N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound with full regulatory compliance including proper classification, labeling, and safety documentation according to European standards. As experienced chemical distributors, OYSI ensures reliable supply chain management and technical support for industrial customers across Europe. Contact OYSI directly for availability, specifications, and pricing information tailored to your specific requirements.
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N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine is a dangerous good. We support you with labeling, packaging, and transport documentation.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.