1H-indole-5,6-diol

1H-indole-5,6-diol is an organic chemical compound with the molecular formula C8H7NO2 and CAS number 3131-52-0. This indole derivative features two hydroxyl groups positioned at the 5 and 6 positions of the indole ring structure. With a molecular weight of 149.15 g/mol, it belongs to the class of substituted indoles and is classified as a hazardous substance requiring proper handling precautions due to its toxicity and corrosive properties.

1H-indole-5,6-diol is a solid organic compound at room temperature with the molecular formula C8H7NO2 and a molecular weight of 149.15 g/mol. As an indole derivative with hydroxyl substituents, it typically appears as a crystalline powder. The presence of hydroxyl groups and the nitrogen-containing heterocycle suggests moderate polarity and potential solubility in polar solvents. Specific physical properties such as melting point, color, and exact solubility data should be confirmed through technical documentation.

1H-indole-5,6-diol serves primarily as an intermediate in pharmaceutical and chemical synthesis applications. This compound is utilized in the production of various bioactive molecules and pharmaceutical intermediates due to its indole structure, which is a common motif in many drugs and natural products. It may also be employed in research applications for the synthesis of more complex indole derivatives and in studies related to neurotransmitter analogs and other biologically active compounds.

1H-indole-5,6-diol must be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing due to its Acute Tox. 4 and Eye Dam. 1 classifications. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid direct skin and eye contact, as the substance can cause severe eye damage. All handling procedures should follow established chemical safety protocols and workplace safety guidelines.

1H-indole-5,6-diol should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Due to its hazard classification, storage areas must be clearly labeled and access restricted to authorized personnel only. The storage location should be equipped with appropriate spill containment measures and emergency equipment. Regular inventory checks and container integrity inspections are recommended to ensure safe storage conditions and prevent environmental release.

Immediate action is required if contact occurs with 1H-indole-5,6-diol. For eye contact, flush immediately with plenty of clean water for at least 15 minutes and seek immediate medical attention due to the Eye Dam. 1 classification. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water. If ingested, do not induce vomiting and seek medical attention immediately. In all cases of exposure, contact emergency medical services and provide the safety data sheet to medical personnel.

1H-indole-5,6-diol must be disposed of as hazardous chemical waste in accordance with local, national, and EU waste regulations. The substance cannot be disposed of through normal waste streams due to its toxicity and environmental hazard classification (Aquatic Chronic 2). Disposal should be arranged through licensed hazardous waste management companies. Containers must be properly labeled, and waste manifests should accurately describe the material. Empty containers may also require special disposal procedures due to residual contamination.

1H-indole-5,6-diol is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. This classification requires specific packaging, labeling, and documentation requirements for road transport within Europe. Packages must bear appropriate hazard labels and proper shipping names. Transport vehicles must carry emergency response information, and drivers require ADR training certification. All shipments must comply with international dangerous goods regulations and be accompanied by proper transport documentation.

1H-indole-5,6-diol is subject to EU REACH regulation requirements for chemical registration, evaluation, and authorization. The substance must be classified and labeled according to CLP regulation, displaying GHS07, GHS05, and GHS09 pictograms with the signal word 'Danger'. While not currently listed as a SVHC (Substance of Very High Concern), it remains subject to standard chemical safety assessments and may be subject to additional national regulations regarding handling, use, and disposal in different EU member states.

1H-indole-5,6-diol is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound to qualified industrial and research customers across Europe, ensuring proper regulatory compliance and documentation. As a hazardous substance requiring specialized handling, purchases are typically restricted to professional users with appropriate facilities and safety measures. Contact OYSI directly for availability, technical specifications, and pricing information for your specific application requirements.