Hydroxylamine

H3NO

hydroxylamine

CAS11104-93-1

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Identification

CAS Number
11104-93-1
UN Number
1975
PubChem CID
787

Physical-chemical properties

Molecular Formula
H3NO
Molar Mass
33.03 g/mol
IUPAC Name
hydroxylamine

Chemical Identifiers

InChI
InChI=1S/H3NO/c1-2/h2H,1H2
InChI Key
AVXURJPOCDRRFD-UHFFFAOYSA-N

Overview

Hydroxylamine (CAS 11104-93-1) is an inorganic compound with the molecular formula H3NO, characterized by its strong reducing properties and chemical instability. This versatile chemical intermediate serves as a crucial building block in various industrial applications, particularly in pharmaceutical synthesis and analytical chemistry. With a molecular weight of 33.03 g/mol, hydroxylamine exists as a colorless crystalline solid in its pure form, though it is commonly handled and distributed as aqueous solutions or stable salt derivatives due to its inherent instability. The compound exhibits strong nucleophilic and reducing characteristics, making it valuable for selective chemical transformations. Its reactivity profile includes the ability to form stable oximes when reacting with carbonyl compounds, a property extensively utilized in organic synthesis and analytical procedures. Safety considerations are paramount when handling hydroxylamine, as it can decompose explosively under certain conditions and requires careful storage and transportation protocols, reflected in its ADR Class 2 classification. In industrial applications, hydroxylamine finds primary use in pharmaceutical manufacturing as an intermediate for producing various active pharmaceutical ingredients. The chemical industry also employs it in the synthesis of specialty chemicals and as a reducing agent in metallurgical processes. Additionally, analytical laboratories utilize hydroxylamine derivatives for quantitative determination of carbonyl compounds and in various spectroscopic applications. Unlike simpler nitrogen compounds such as nitrous oxide, hydroxylamine's unique structure allows for more complex chemical transformations, making it particularly valuable in fine chemical synthesis where precise molecular modifications are required. OYSI maintains reliable supply chains for hydroxylamine and its derivatives, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

No Hazard Classification

This substance is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

Transport (ADR)

UN Number1975
ADR Class2
Packing Group
Tunnel CodeD
Proper Shipping NameStickstoffmonoxid + Stickstoffdioxid, Gemisch, unter Druck verflüssigt
Marine PollutantNo

Frequently Asked Questions

What is hydroxylamine?

Hydroxylamine is an inorganic compound with the chemical formula H3NO and molecular weight of 33.03 g/mol. It serves as an important chemical intermediate and reducing agent in various industrial processes. This compound contains both amino and hydroxyl functional groups, making it versatile for organic synthesis reactions. Hydroxylamine is commonly used in pharmaceutical manufacturing, polymer production, and as a precursor for other nitrogen-containing compounds in chemical industry applications.

What are the physicochemical properties of hydroxylamine?

Hydroxylamine appears as white crystalline solid or colorless crystals at room temperature. It exhibits high water solubility due to its polar nature and ability to form hydrogen bonds. The compound has a characteristic ammonia-like odor and is hygroscopic, readily absorbing moisture from air. Its molecular structure contains nitrogen-oxygen and nitrogen-hydrogen bonds, contributing to its reactivity. The substance decomposes upon heating and shows strong reducing properties in chemical reactions.

What is hydroxylamine used for?

Hydroxylamine serves multiple industrial applications as a chemical intermediate and reducing agent. It is extensively used in pharmaceutical synthesis for producing various medications and active pharmaceutical ingredients. The compound plays a crucial role in polymer chemistry, particularly in the manufacture of nylon and other synthetic materials. Additionally, hydroxylamine functions as an antioxidant in rubber processing, a flotation agent in mining operations, and a precursor for hydroxamic acids used in metal extraction processes.

How to handle hydroxylamine safely?

Hydroxylamine requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid contact with skin, eyes, and mucous membranes. Use non-sparking tools and equipment to prevent ignition sources. Ensure proper grounding of containers during transfer operations. Train personnel on emergency procedures and maintain eyewash stations and safety showers in work areas.

How to store hydroxylamine correctly?

Hydroxylamine should be stored in tightly sealed containers in cool, dry, well-ventilated areas away from heat sources and direct sunlight. Keep containers in original packaging and protect from moisture due to its hygroscopic nature. Store separately from incompatible materials such as strong oxidizers, acids, and bases. Maintain storage temperatures below recommended limits and ensure proper inventory rotation using first-in-first-out principles. Regularly inspect containers for signs of deterioration or leakage.

What to do in case of contact with hydroxylamine?

Hydroxylamine exposure requires immediate first aid measures depending on the contact route. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. If eye contact occurs, flush immediately with clean water for 15-20 minutes while holding eyelids open. In case of inhalation, move person to fresh air and monitor breathing. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult medical professionals after any significant exposure incident.

How to dispose of hydroxylamine appropriately?

Hydroxylamine disposal must comply with local, national, and international waste management regulations. The substance should be treated as hazardous chemical waste requiring specialized disposal methods. Contact licensed waste disposal companies for proper collection and treatment. Never dispose of hydroxylamine through regular drainage systems or municipal waste streams. Small quantities may require neutralization under controlled conditions before disposal. Always consult local environmental authorities for specific disposal requirements and maintain proper documentation of waste disposal activities.

How to transport hydroxylamine?

Hydroxylamine transportation falls under ADR class 2 regulations for dangerous goods. The substance requires appropriate packaging, labeling, and documentation according to international transport standards. Use UN-approved containers and ensure proper marking with hazard identification numbers. Transport vehicles must comply with ADR requirements including equipment specifications and driver training. Maintain proper shipping papers and emergency response information during transit. Coordinate with logistics providers experienced in handling chemical products to ensure regulatory compliance.

Is hydroxylamine subject to specific regulations?

Hydroxylamine is subject to various chemical regulations including REACH registration requirements for European markets. The substance must comply with CLP classification and labeling standards for proper hazard communication. Manufacturers and importers need to fulfill REACH obligations including safety data sheet provision and exposure scenario development. Regular regulatory updates may affect handling, storage, and use requirements. Companies should monitor regulatory changes and ensure compliance with occupational health and safety standards in their respective jurisdictions.

Where to buy hydroxylamine in Europe?

Hydroxylamine is available through OYSI, a trusted European distributor of technical chemical products. OYSI provides reliable supply chains for industrial customers across European markets, ensuring product quality and regulatory compliance. The company offers technical support and proper documentation including safety data sheets and certificates of analysis. Professional customers can contact OYSI directly to discuss specific requirements, quantities, and delivery options. OYSI maintains strong relationships with manufacturers to ensure consistent product availability for European industrial applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.