Ethyl 2-bromoacetate

Ethyl 2-bromoacetate is an organic compound with the molecular formula C4H7BrO2 and CAS number 105-36-2. This brominated ester has a molecular weight of 167 g/mol and belongs to the family of haloacetates. It is classified as a highly toxic substance with acute toxicity categories ranging from 1 to 2, requiring careful handling and appropriate safety measures in professional environments.

Ethyl 2-bromoacetate is typically a colorless to pale yellow liquid at room temperature with a characteristic ester odor. As an ester compound, it exhibits limited solubility in water but shows good solubility in organic solvents such as ethanol, diethyl ether, and other common organic media. Its brominated structure makes it reactive and suitable for various synthetic applications.

Ethyl 2-bromoacetate serves primarily as an important intermediate in organic synthesis and pharmaceutical manufacturing. It is widely used as an alkylating agent in the production of various chemicals, including pharmaceuticals, agrochemicals, and specialty chemicals. The compound is particularly valuable in research laboratories for synthetic chemistry applications and as a building block for more complex molecular structures.

Ethyl 2-bromoacetate requires extreme caution during handling due to its high toxicity classification. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas or fume hoods. Work should be conducted in controlled environments with emergency procedures readily available. Avoid skin contact, inhalation, and ingestion at all costs due to its acute toxicity properties.

Ethyl 2-bromoacetate must be stored in tightly sealed containers in cool, dry, well-ventilated areas away from heat sources and incompatible materials. Storage areas should be equipped with appropriate spill containment measures and restricted access due to the substance's high toxicity. Keep away from strong bases, oxidizing agents, and reducing agents to prevent dangerous reactions or decomposition.

Immediate action is crucial in case of contact with ethyl 2-bromoacetate due to its high toxicity. For skin contact, remove contaminated clothing and rinse affected area with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with water and seek medical attention. If inhaled or ingested, seek immediate medical assistance and contact poison control centers.

Ethyl 2-bromoacetate disposal must comply with local and national hazardous waste regulations due to its toxic classification. The substance should never be disposed of down drains or in regular waste streams. Professional hazardous waste disposal services must be contacted for proper treatment and disposal. Small quantities should be neutralized and treated according to established laboratory waste protocols under expert supervision.

Ethyl 2-bromoacetate is classified under ADR class 6.1 (toxic substances) with packing group II, indicating moderate toxicity requiring specific transport precautions. Proper packaging, labeling with GHS06 pictograms, and documentation are mandatory for transportation. Only certified carriers experienced in handling toxic chemicals should transport this substance, following all applicable dangerous goods regulations and emergency response procedures.

Ethyl 2-bromoacetate is subject to various chemical regulations including REACH registration requirements in Europe and CLP classification for hazard communication. While not currently listed as a SVHC (Substance of Very High Concern), its high toxicity classification requires compliance with occupational health and safety regulations. Users must maintain safety data sheets and implement appropriate risk management measures.

Ethyl 2-bromoacetate is available through OYSI, a European distributor specializing in technical chemicals and laboratory reagents. As a professional chemical distributor, OYSI ensures proper handling, documentation, and regulatory compliance for this toxic substance. Contact OYSI directly for availability, technical specifications, and regulatory documentation required for your specific application and location within Europe.