Ethyl 2-bromoacetate

Ethyl 2-bromoacetate is an organic chemical compound with the molecular formula C4H7BrO2 and CAS number 105-36-2. This brominated ester has a molecular weight of 167 g/mol and belongs to the family of haloacetic acid esters. It is classified as a highly toxic substance with acute toxicity properties, requiring careful handling and storage. The compound is commonly used as an intermediate in organic synthesis and pharmaceutical manufacturing processes.

Ethyl 2-bromoacetate is typically a colorless to pale yellow liquid at room temperature with a characteristic ester odor. The compound has good solubility in organic solvents such as ethanol, ether, and chloroform, but limited solubility in water. It has a boiling point around 158-160°C and a density of approximately 1.5 g/cm³. The presence of the bromine atom makes it reactive towards nucleophilic substitution reactions.

Ethyl 2-bromoacetate is primarily used as a versatile intermediate in organic synthesis and pharmaceutical manufacturing. It serves as an alkylating agent in the production of various pharmaceuticals, agrochemicals, and fine chemicals. The compound is particularly valuable in the synthesis of amino acid derivatives, heterocyclic compounds, and other bioactive molecules. It is also used in research laboratories for chemical modifications and as a building block in medicinal chemistry applications.

Ethyl 2-bromoacetate requires strict safety measures due to its high acute toxicity classification. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in a well-ventilated area or under a fume hood to avoid inhalation exposure. Prevent skin and eye contact, and avoid breathing vapors. Use only non-sparking tools and ensure proper grounding when handling. Keep away from heat sources and incompatible materials.

Ethyl 2-bromoacetate should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. Keep the substance in original containers made of compatible materials, typically glass or appropriate plastic. Store separately from strong bases, oxidizing agents, and reducing agents to prevent dangerous reactions. Maintain storage temperature below 25°C and ensure adequate containment measures to prevent environmental release in case of spills.

Ethyl 2-bromoacetate exposure requires immediate emergency response due to its high toxicity. For skin contact, immediately remove contaminated clothing and rinse affected area with plenty of water for at least 15 minutes. In case of eye contact, flush thoroughly with water and seek immediate medical attention. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek urgent medical care. Always consult a physician and provide the safety data sheet.

Ethyl 2-bromoacetate disposal must comply with local and international hazardous waste regulations due to its toxic classification. The substance cannot be disposed of with regular waste and requires specialized hazardous waste treatment. Contact licensed waste disposal companies for proper collection and treatment. Small laboratory quantities may be neutralized through controlled chemical treatment by qualified personnel. Always check local environmental regulations and obtain proper waste disposal permits before disposal activities.

Ethyl 2-bromoacetate is classified under ADR Class 6.1 (Toxic substances), Packing Group II, requiring specific transport regulations. Packages must bear appropriate UN identification numbers and hazard labels including the GHS06 skull and crossbones pictogram. Use approved packaging materials and ensure proper documentation including transport emergency cards. Only authorized carriers with hazardous materials certification should handle transportation. Comply with quantity limitations and segregation requirements during transport.

Ethyl 2-bromoacetate is subject to various regulatory frameworks including REACH registration requirements for European markets and CLP classification as an acute toxic substance. The compound requires safety data sheets and appropriate labeling with 'Danger' signal word and GHS06 pictogram. While not currently listed as an SVHC substance, it may be subject to authorization or restriction procedures. Users must comply with occupational exposure limits and workplace safety regulations in their respective jurisdictions.

Ethyl 2-bromoacetate is available through OYSI, a specialized European distributor of technical chemicals and laboratory reagents. As a professional chemical supplier, OYSI ensures compliance with all regulatory requirements including proper documentation, packaging, and transport protocols for this toxic substance. The company serves various industries including pharmaceuticals, research institutions, and chemical manufacturing. Contact OYSI directly for availability, specifications, and regulatory compliance documentation for your specific application requirements.