Ethanethiol

C2H6S

ethanethiol

CAS75-08-1
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
75-08-1
EC Number
200-837-3
UN Number
2363
Index Number
016-022-00-9
PubChem CID
6343

Physical-chemical properties

Molecular Formula
C2H6S
Molar Mass
62.14 g/mol
IUPAC Name
ethanethiol

Chemical Identifiers

InChI
InChI=1S/C2H6S/c1-2-3/h3H,2H2,1H3
InChI Key
DNJIEGIFACGWOD-UHFFFAOYSA-N

Overview

Ethanethiol (CAS 75-08-1) is an organosulfur compound characterized by its distinctive mercaptan functionality and extremely low odor threshold. This volatile liquid represents one of the simplest aliphatic thiols, featuring a sulfur-hydrogen bond that confers unique chemical reactivity and notable olfactory properties. With its molecular formula C2H6S and molecular weight of 62.14 g/mol, ethanethiol exhibits typical thiol behavior including strong nucleophilic character and readily detectable organoleptic properties even at trace concentrations. The compound presents significant safety considerations, classified under multiple hazard categories including highly flammable liquid (Flam. Liq. 1) and acute toxicity classifications. Its vapor pressure and volatility require careful handling protocols, particularly given its potential for rapid vapor accumulation and environmental impact. The substance displays aquatic toxicity (Aquatic Acute 1, Aquatic Chronic 1), necessitating appropriate containment and disposal procedures. Transportation falls under ADR Class 3 regulations due to its flammable nature. Industrial applications of ethanethiol primarily center on chemical synthesis and specialty manufacturing processes. The compound serves as an important intermediate in pharmaceutical synthesis, where its thiol functionality enables diverse coupling reactions. Additionally, it finds use in the production of sulfur-containing polymers and as a precursor in organosulfur chemistry applications. Unlike related compounds such as prop-2-enenitrile, ethanethiol's saturated structure provides specific reactivity patterns valuable in targeted synthetic pathways. The mercaptan group's high reactivity makes ethanethiol particularly useful in processes requiring sulfur incorporation or thiol-based chemistry. Its applications often intersect with industries utilizing other reactive intermediates, though its handling requirements differ significantly from compounds like 1,3-dichloroprop-1-ene. OYSI maintains reliable supply chains for ethanethiol, supporting European industrial customers with consistent availability and technical expertise.

Safety & Classification

Danger
Classification:

Flam. Liq. 1; Acute Tox. 3; Acute Tox. 4; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H224

Extremely flammable liquid and vapour.

H331

Toxic if inhaled.

H302

Harmful if swallowed.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2363
ADR Class3
Packing GroupI
Tunnel CodeD/E
Proper Shipping NameEthylmercaptan
Marine PollutantNo

Frequently Asked Questions

What is ethanethiol?

Ethanethiol is an organosulfur compound with the molecular formula C2H6S and CAS number 75-08-1. This chemical substance belongs to the thiol family, characterized by the presence of a sulfur-hydrogen (-SH) functional group. With a molecular weight of 62.14 g/mol, ethanethiol is classified as a highly flammable liquid with significant toxicity and environmental hazards, requiring careful handling in industrial applications.

What are the physicochemical properties of ethanethiol?

Ethanethiol is a colorless liquid at room temperature with an extremely strong, disagreeable odor reminiscent of rotten eggs or garlic. It has a low boiling point and high volatility, making it easily detectable even at very low concentrations. The compound is slightly soluble in water but readily dissolves in organic solvents such as alcohols and ethers, typical of organosulfur compounds.

What is ethanethiol used for?

Ethanethiol is primarily used as a chemical intermediate in the synthesis of various organosulfur compounds and pharmaceuticals. It serves as an odorant additive for natural gas and propane to enable leak detection due to its distinctive smell. Additionally, it finds applications in the production of pesticides, rubber chemicals, and as a reagent in organic synthesis reactions in laboratory and industrial settings.

How to handle ethanethiol safely?

Ethanethiol requires strict safety measures due to its high flammability and toxicity. Personnel must wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods, away from ignition sources. Emergency shower and eyewash stations should be readily accessible, and only trained personnel should handle this hazardous chemical.

How to store ethanethiol correctly?

Ethanethiol must be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames. Containers should be tightly sealed and made of compatible materials, stored in secondary containment systems. The storage area should be separated from incompatible substances such as strong oxidizers and acids. Temperature control and vapor detection systems are recommended for safe storage.

What to do in case of contact with ethanethiol?

Immediate action is required upon contact with ethanethiol. For skin contact, remove contaminated clothing and wash thoroughly with soap and water. In case of eye contact, rinse immediately with plenty of water for at least 15 minutes. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention in all cases.

How to dispose of ethanethiol appropriately?

Ethanethiol disposal must comply with local and European waste regulations due to its hazardous classification. The substance cannot be disposed of in regular waste streams and requires specialized hazardous waste treatment. Contact licensed waste disposal companies for proper collection and treatment. Small quantities may be neutralized or incinerated under controlled conditions by qualified professionals following regulatory guidelines.

How to transport ethanethiol?

Ethanethiol is classified under ADR Class 3 (flammable liquids) Packing Group I, indicating high danger during transport. Specialized packaging, labeling with GHS pictograms (GHS02, GHS06, GHS09), and proper documentation are mandatory. Only authorized carriers with appropriate equipment and training can transport this substance. Emergency response information must accompany shipments for incident management.

Is ethanethiol subject to specific regulations?

Ethanethiol is subject to comprehensive European chemical regulations including REACH registration and CLP classification requirements. It carries the signal word 'Danger' with multiple hazard classifications including flammable liquid, acute toxicity, and aquatic toxicity. While not currently listed as a SVHC substance, it requires safety data sheets, proper labeling, and compliance with occupational exposure limits and environmental protection measures.

Where to buy ethanethiol in Europe?

Ethanethiol is available through OYSI, a leading European distributor of technical chemicals. As a specialized chemical requiring proper handling and documentation, it is essential to source from reputable suppliers who ensure regulatory compliance and provide comprehensive safety data sheets. OYSI offers reliable supply chains and technical support for industrial customers requiring this organosulfur compound for their applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.