Chromen-2-one

Chromen-2-one is an organic heterocyclic compound with the molecular formula C9H6O2 and CAS number 91-64-5. Also known as coumarin, it features a benzene ring fused to a pyrone ring, creating a bicyclic aromatic lactone structure. With a molecular weight of 146.14 g/mol, this compound serves as an important building block in organic synthesis and occurs naturally in many plants, giving them their characteristic sweet vanilla-like scent.

Chromen-2-one appears as white to pale yellow crystalline flakes or powder with a characteristic sweet, vanilla-like odor. It has a melting point around 68-70°C and is sparingly soluble in water but readily soluble in ethanol, ether, and other organic solvents. The compound exhibits aromatic stability due to its conjugated system and can undergo various chemical reactions typical of both aromatic compounds and lactones.

Chromen-2-one serves as a key intermediate in pharmaceutical synthesis, particularly for anticoagulant drugs like warfarin. It's widely used in the fragrance and flavor industry due to its pleasant vanilla-like aroma, appearing in perfumes, cosmetics, and food additives. Additionally, it functions as a precursor for optical brighteners, laser dyes, and various fine chemicals in research and industrial applications.

Chromen-2-one should be handled with standard laboratory safety precautions including wearing protective gloves, safety glasses, and working in well-ventilated areas. While it shows no specific hazard classification, avoid inhalation of dust and prevent skin and eye contact. Use appropriate personal protective equipment when handling larger quantities and ensure good housekeeping practices to minimize dust formation during transfer and weighing operations.

Chromen-2-one should be stored in tightly sealed containers in a cool, dry place away from direct sunlight and heat sources. Keep containers in well-ventilated areas below 25°C to prevent degradation. Avoid storage near strong oxidizing agents and ensure containers are properly labeled. The material should be protected from moisture and contamination to maintain its quality and prevent caking or discoloration over time.

In case of skin contact with chromen-2-one, immediately wash the affected area with plenty of soap and water. If eye contact occurs, rinse thoroughly with clean water for at least 15 minutes and seek medical attention if irritation persists. If inhaled, move the person to fresh air immediately. For ingestion, rinse mouth with water and seek medical advice. Although not classified as hazardous, prompt decontamination is recommended.

Chromen-2-one waste should be disposed of according to local and national regulations for organic chemical waste. Small laboratory quantities can typically be collected in appropriate solvent waste containers for professional disposal. Larger amounts should be handled by licensed waste management companies. Do not discharge into drains or the environment. Contaminated packaging should also be disposed of as chemical waste following applicable regulatory requirements.

Chromen-2-one is not classified under ADR dangerous goods regulations, making it relatively straightforward to transport. Standard packaging requirements apply, using appropriate containers that prevent spillage and contamination. Ensure packages are properly labeled with product identification and relevant safety information. While not requiring dangerous goods documentation, shipments should comply with general transport regulations and include appropriate safety data sheets for handling personnel.

Chromen-2-one is regulated under REACH regulation in Europe and requires registration for commercial use above certain tonnage thresholds. It is not classified as an SVHC (Substance of Very High Concern) and shows no specific hazard classification under CLP regulation. However, users should comply with standard chemical handling regulations, workplace safety requirements, and any sector-specific guidelines that may apply to their particular applications.

Chromen-2-one is available through OYSI, a trusted European distributor of specialty chemicals serving industrial and research customers across Europe. OYSI provides reliable supply chains, technical support, and regulatory compliance assistance for chromen-2-one and related organic intermediates. Contact OYSI directly for pricing, availability, and delivery options tailored to your specific requirements, whether for research quantities or industrial-scale applications.