(4-nitrophenyl)hydrazine

C6H7N3O2

CAS100-16-3

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Identification

CAS Number
100-16-3
EC Number
202-824-8
UN Number
3376
PubChem CID
3310889

Physical-chemical properties

Molecular Formula
C6H7N3O2
Molar Mass
153.14 g/mol
IUPAC Name
(4-nitrophenyl)hydrazine

Chemical Identifiers

InChI
InChI=1S/C6H7N3O2/c7-8-5-1-3-6(4-2-5)9(10)11/h1-4,8H,7H2
InChI Key
KMVPXBDOWDXXEN-UHFFFAOYSA-N

Overview

(4-nitrophenyl)hydrazine (CAS 100-16-3) is an aromatic hydrazine derivative featuring a nitro-substituted phenyl group with distinctive chemical reactivity properties. This specialized organic compound belongs to the family of substituted hydrazines, characterized by its unique molecular structure combining a hydrazine functional group with a para-nitrophenyl moiety. With the molecular formula C6H7N3O2 and a molecular weight of 153.14 g/mol, (4-nitrophenyl)hydrazine exhibits distinctive chemical properties that make it valuable for various industrial applications. The presence of both the electron-withdrawing nitro group and the nucleophilic hydrazine functionality creates an interesting electronic environment within the molecule. This dual character influences its reactivity patterns and makes it particularly useful in synthetic chemistry applications. The compound's structure allows for diverse chemical transformations, including condensation reactions, cyclization processes, and reduction reactions. From a safety perspective, (4-nitrophenyl)hydrazine is classified under ADR Class 4.1 as a flammable solid, requiring appropriate handling precautions during storage and transportation. Industrial users should implement proper safety protocols when working with this material, including adequate ventilation and personal protective equipment. The compound finds primary applications in pharmaceutical intermediate synthesis, where its reactive hydrazine group serves as a building block for various heterocyclic compounds. It is also utilized in analytical chemistry for the development of detection methods and in specialty chemical manufacturing. Unlike related compounds such as 1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane, (4-nitrophenyl)hydrazine offers specific reactivity patterns that make it particularly suitable for targeted synthetic applications. OYSI maintains reliable supply channels for (4-nitrophenyl)hydrazine to support European industrial customers' specialized chemical requirements.

Safety & Classification

No Hazard Classification

This substance is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

Transport (ADR)

UN Number3376
ADR Class4.1
Packing GroupI
Tunnel CodeB
Proper Shipping Name4-Nitrophenylhydrazin, Wasser >= 30 %
Marine PollutantNo

Frequently Asked Questions

What is (4-nitrophenyl)hydrazine?

(4-nitrophenyl)hydrazine is an organic chemical compound with the molecular formula C6H7N3O2 and CAS number 100-16-3. This aromatic hydrazine derivative features a phenyl ring substituted with a nitro group at the para position and a hydrazine functional group. With a molecular weight of 153.14 g/mol, it serves as an important intermediate in organic synthesis and pharmaceutical manufacturing processes.

What are the physicochemical properties of (4-nitrophenyl)hydrazine?

(4-nitrophenyl)hydrazine typically appears as a yellow to orange crystalline solid at room temperature. The compound exhibits moderate solubility in polar organic solvents and limited solubility in water. Its melting point and other specific physical properties depend on purity and crystalline form. The presence of both nitro and hydrazine functional groups influences its reactivity and stability under various conditions.

What is (4-nitrophenyl)hydrazine used for?

(4-nitrophenyl)hydrazine is primarily used as an intermediate in pharmaceutical synthesis and organic chemistry applications. It serves as a key building block for manufacturing various pharmaceutical compounds, dyes, and chemical intermediates. The compound is particularly valuable in the synthesis of heterocyclic compounds and as a reagent in analytical chemistry for developing colorimetric assays and detection methods.

How to handle (4-nitrophenyl)hydrazine safely?

(4-nitrophenyl)hydrazine should be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation exposure. Avoid skin and eye contact, and prevent ingestion. Use proper laboratory techniques when transferring or weighing the material, and ensure emergency eyewash and shower facilities are readily accessible.

How to store (4-nitrophenyl)hydrazine correctly?

(4-nitrophenyl)hydrazine should be stored in tightly closed containers in a cool, dry place away from direct sunlight and heat sources. Keep the material in its original packaging and maintain proper labeling. Store separately from strong oxidizing agents, acids, and bases to prevent incompatible reactions. Ensure storage areas have adequate ventilation and temperature control to maintain product stability and safety.

What to do in case of contact with (4-nitrophenyl)hydrazine?

In case of skin contact with (4-nitrophenyl)hydrazine, immediately wash the affected area with plenty of soap and water for at least 15 minutes. For eye contact, flush thoroughly with clean water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention while providing the safety data sheet to medical personnel.

How to dispose of (4-nitrophenyl)hydrazine properly?

(4-nitrophenyl)hydrazine waste must be disposed of according to local and national environmental regulations. The material should be collected in appropriate hazardous waste containers and handed over to licensed waste disposal companies. Do not discharge into sewers, waterways, or soil. Consult local environmental authorities for specific disposal requirements and ensure proper waste classification and documentation throughout the disposal process.

How to transport (4-nitrophenyl)hydrazine?

(4-nitrophenyl)hydrazine is classified under ADR Class 4.1 (Flammable Solids), Packing Group I, indicating it requires careful handling during transport. The material must be packaged in UN-approved containers with proper labeling and documentation. Transportation should comply with international dangerous goods regulations including ADR for road transport in Europe. Ensure proper segregation from incompatible materials during shipping.

Is (4-nitrophenyl)hydrazine subject to specific regulations?

(4-nitrophenyl)hydrazine is subject to standard chemical regulations including REACH registration requirements in the European Union and CLP classification and labeling regulations. The substance is not currently listed as a Substance of Very High Concern (SVHC). Users must comply with occupational safety regulations, environmental protection laws, and proper chemical management practices. Regular safety data sheet updates ensure compliance with evolving regulatory requirements.

Where to buy (4-nitrophenyl)hydrazine in Europe?

(4-nitrophenyl)hydrazine is available through OYSI, a specialized European distributor of technical chemicals serving various industries across the continent. OYSI provides reliable supply chains and technical support for chemical procurement needs. For availability, specifications, and ordering information, contact OYSI directly through their sales channels. They can provide detailed product information, safety documentation, and logistics support for European customers.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.