Butyl nitrite

C4H9NO2

butyl nitrite

CAS544-16-1
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
Danger

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Identification

CAS Number
544-16-1
EC Number
208-862-1
UN Number
2351
Index Number
007-016-00-7
PubChem CID
10996

Physical-chemical properties

Molecular Formula
C4H9NO2
Molar Mass
103.12 g/mol
IUPAC Name
butyl nitrite

Chemical Identifiers

InChI
InChI=1S/C4H9NO2/c1-2-3-4-7-5-6/h2-4H2,1H3
InChI Key
JQJPBYFTQAANLE-UHFFFAOYSA-N

Overview

Butyl nitrite (CAS 544-16-1) is an organic nitrite ester with high flammability and acute toxicity properties, requiring careful handling in industrial applications. This volatile organic compound belongs to the alkyl nitrite family and serves as an important intermediate in various chemical processes. With its molecular formula C4H9NO2 and molecular weight of 103.12 g/mol, butyl nitrite exhibits characteristic properties of nitrite esters, including its distinctive odor and relatively low boiling point. The compound is classified under multiple hazard categories, including Flammable Liquid Category 2 and Acute Toxicity Category 3, reflecting its significant safety considerations during storage, handling, and transportation. The chemical structure of butyl nitrite makes it highly reactive, particularly in the presence of heat, light, or certain catalysts. Its classification under ADR Class 3 indicates special transportation requirements due to its flammable nature. The GHS02 and GHS06 pictograms emphasize both fire hazards and acute toxicity risks, requiring comprehensive safety protocols in industrial environments. Unlike related compounds such as prop-2-enenitrile or 4-methylpyridine, butyl nitrite's nitrite functional group confers unique reactivity patterns that are exploited in specific synthetic pathways. Primary industrial applications include its use as a chemical intermediate in organic synthesis, particularly in the production of pharmaceutical compounds and specialty chemicals. The compound also finds application in certain analytical procedures where its specific chemical properties are advantageous. Additionally, butyl nitrite serves as a reagent in various chemical transformations, including diazotization reactions and other nitrogen-based chemistry applications. OYSI maintains reliable supply chains for butyl nitrite, ensuring consistent availability for qualified industrial customers across Europe while adhering to all regulatory requirements for this controlled chemical substance.

Safety & Classification

Danger
Classification:

Flam. Liq. 2; Acute Tox. 3 *; Acute Tox. 3 *

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

H331

Toxic if inhaled.

H301

Toxic if swallowed.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2351
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameButylnitrit
Marine PollutantNo

Frequently Asked Questions

What is butyl nitrite?

Butyl nitrite is an organic chemical compound with the molecular formula C4H9NO2 and CAS number 544-16-1. It belongs to the alkyl nitrite family and has a molecular weight of 103.12 g/mol. This substance is classified as a flammable liquid and acutely toxic compound, requiring careful handling due to its hazardous properties. It appears as a pale yellow liquid with a characteristic fruity odor and is commonly used in various industrial applications.

What are the physicochemical properties of butyl nitrite?

Butyl nitrite is a pale yellow to colorless liquid at room temperature with a distinctive sweet, fruity odor. It has a molecular weight of 103.12 g/mol and is slightly soluble in water but miscible with organic solvents like alcohol and ether. The compound is volatile and decomposes readily when exposed to light, heat, or alkaline conditions. It has a relatively low boiling point and high vapor pressure, making it easily evaporable at ambient temperatures.

What is butyl nitrite used for?

Butyl nitrite is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. It serves as a nitrosating agent in chemical reactions and is employed in the production of various organic compounds. In industrial applications, it functions as a solvent and reagent in specialized chemical processes. The compound is also utilized in research laboratories for analytical purposes and as a precursor for synthesizing other nitrite esters and related chemical derivatives.

How to handle butyl nitrite safely?

Butyl nitrite requires careful handling due to its flammable and toxic nature. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing when working with this substance. Ensure adequate ventilation to prevent vapor accumulation and avoid sources of ignition. Work in a well-ventilated area or under a fume hood, and never eat, drink, or smoke while handling. Keep containers tightly closed and use only non-sparking tools during manipulation.

How to store butyl nitrite correctly?

Butyl nitrite must be stored in a cool, dry, well-ventilated area away from heat sources, direct sunlight, and ignition sources. Keep containers tightly sealed in their original packaging and store below 25°C to prevent decomposition. The substance should be separated from oxidizing agents, acids, and alkaline materials due to incompatibility risks. Store in a designated flammable liquids cabinet and ensure adequate fire suppression systems are available in the storage area.

What to do in case of contact with butyl nitrite?

Butyl nitrite exposure requires immediate action due to its acute toxicity. In case of skin contact, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If inhaled, move the person to fresh air immediately and seek medical attention. For eye contact, flush with clean water for at least 15 minutes while holding eyelids open. If ingested, do not induce vomiting and seek immediate medical assistance while providing safety data sheet information to healthcare providers.

How to dispose of butyl nitrite appropriately?

Butyl nitrite disposal must comply with local and national hazardous waste regulations due to its classification as dangerous goods. The substance cannot be disposed of in regular waste streams and requires specialized treatment at authorized hazardous waste facilities. Collect waste in compatible, labeled containers and arrange collection through licensed waste management companies. Never pour down drains or sewers, and avoid incineration without proper emission controls due to toxic decomposition products formation.

How to transport butyl nitrite?

Butyl nitrite is classified as dangerous goods under ADR regulations with UN class 3 (flammable liquids) and packing group II. Transportation requires appropriate packaging, labeling with GHS02 and GHS06 pictograms, and proper shipping documentation including safety data sheets. Vehicles must comply with ADR requirements for flammable liquids transport, including proper ventilation and fire safety equipment. Only trained personnel should handle transportation, and emergency response procedures must be available during transit.

Is butyl nitrite subject to specific regulations?

Butyl nitrite is subject to various European regulations including REACH registration requirements and CLP classification standards. The substance is classified under the Globally Harmonized System with 'Danger' signal word and specific hazard statements for flammability and acute toxicity. While not currently listed as a Substance of Very High Concern (SVHC), it requires compliance with occupational health and safety regulations, transportation rules, and waste management directives across EU member states.

Where to buy butyl nitrite in Europe?

Butyl nitrite is available through OYSI, a trusted European distributor of technical chemicals serving industrial and research customers across the continent. OYSI provides high-quality butyl nitrite with proper documentation, safety data sheets, and regulatory compliance support. As a specialized chemical distributor, OYSI ensures reliable supply chains and technical expertise to support customer applications while maintaining strict quality standards and regulatory compliance throughout the European market.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.