Azepane

Azepane is a seven-membered saturated heterocyclic amine with the molecular formula C6H13N and CAS number 111-49-9. This cyclic secondary amine has a molecular weight of 99.17 g/mol and belongs to the azacycloalkane family. Azepane features a single nitrogen atom incorporated into a seven-carbon ring structure, making it an important building block in organic synthesis and pharmaceutical chemistry.

Azepane is a colorless to pale yellow liquid at room temperature with a characteristic amine-like odor. As a secondary amine, it exhibits basic properties and is miscible with water and most organic solvents due to its ability to form hydrogen bonds. The compound has a boiling point around 138-140°C and displays typical aliphatic amine reactivity, including nucleophilic behavior and the ability to form salts with acids.

Azepane serves as a versatile intermediate in pharmaceutical synthesis and fine chemical manufacturing. It is commonly used as a building block for the production of various pharmaceutical compounds, particularly those requiring seven-membered ring structures. The compound also finds applications in the synthesis of specialty chemicals, polymers, and as a reagent in organic synthesis reactions where cyclic secondary amines are needed.

Azepane should be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation of vapors. As with all amines, avoid direct skin and eye contact, and ensure proper grounding when transferring the material to prevent static electricity buildup during handling operations.

Azepane should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers away from strong acids and oxidizing agents to prevent unwanted reactions. Storage areas should be equipped with appropriate spill containment measures and maintained at stable temperatures to preserve product quality and prevent degradation over time.

In case of skin contact with azepane, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with plenty of clean water for at least 15 minutes while keeping eyelids open. If inhaled, move the person to fresh air immediately. Seek medical attention if irritation persists or if large quantities were involved.

Azepane waste must be disposed of according to local, national, and international regulations for chemical waste management. The material should not be poured down drains or disposed of with regular waste. Contact licensed waste disposal companies specialized in chemical waste treatment. Small quantities may be neutralized with appropriate acids under controlled conditions before disposal, following all applicable environmental regulations.

Azepane is classified under ADR Class 3 (Flammable Liquids), Packing Group II, requiring specific packaging and labeling for transport. Containers must meet UN specification standards and display appropriate hazard labels and marking. Transport vehicles must comply with ADR requirements including proper equipment, documentation, and driver training. Ensure proper segregation from incompatible materials during transportation.

Azepane is regulated under REACH regulation in Europe and must comply with CLP classification and labeling requirements. The substance is not currently listed as a SVHC (Substance of Very High Concern) under REACH. Users must ensure compliance with local chemical safety regulations, including proper risk assessments, safety data sheet management, and worker protection measures according to applicable occupational health and safety legislation.

Azepane is available through OYSI, a leading European distributor of specialty chemicals and pharmaceutical intermediates. OYSI provides reliable supply chains across Europe with technical support and regulatory compliance assistance. Contact OYSI directly for product availability, specifications, packaging options, and delivery arrangements to meet your specific requirements for azepane in industrial or research applications.