Anisole

C7H8O

anisole

CAS100-66-3

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Identification

CAS Number
100-66-3
EC Number
202-876-1
UN Number
2222
PubChem CID
7519

Physical-chemical properties

Molecular Formula
C7H8O
Molar Mass
108.14 g/mol
IUPAC Name
anisole

Chemical Identifiers

InChI
InChI=1S/C7H8O/c1-8-7-5-3-2-4-6-7/h2-6H,1H3
InChI Key
RDOXTESZEPMUJZ-UHFFFAOYSA-N

Overview

Anisole (CAS 100-66-3) is an aromatic ether compound with distinctive methoxy functionality and pleasant sweet odor characteristics. This organic compound, also known as methoxybenzene, represents a fundamental aromatic ether widely utilized across various industrial applications. With its molecular formula C7H8O and molecular weight of 108.14 g/mol, anisole features a benzene ring substituted with a methoxy group (-OCH3), making it an important intermediate in organic synthesis and chemical manufacturing processes. Anisole exhibits excellent solvent properties, particularly for organic compounds, and demonstrates good thermal stability under normal handling conditions. The compound appears as a clear, colorless liquid with a characteristic anise-like fragrance, which contributes to its utility in flavoring and fragrance applications. Its aromatic ether structure provides unique reactivity patterns, allowing for various chemical transformations including electrophilic aromatic substitution reactions. From a safety perspective, anisole is classified under ADR Class 3 as a flammable liquid, requiring appropriate storage and handling precautions. While it does not carry specific GHS pictograms or signal words, standard chemical handling protocols should be observed, including adequate ventilation and fire prevention measures. Industrial applications of anisole span multiple sectors, including its use as a solvent in pharmaceutical synthesis, as an intermediate in fine chemical production, and as a component in specialty formulations. The compound serves as a building block for manufacturing various derivatives and finds application in processes where its unique aromatic ether properties are advantageous. Unlike related compounds such as 2-ethylbutyl acetate which serves primarily as a solvent, anisole offers both solvent capabilities and synthetic versatility. OYSI maintains reliable supply chains for anisole to support diverse European industrial requirements.

Safety & Classification

No Hazard Classification

This substance is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

Transport (ADR)

UN Number2222
ADR Class3
Packing GroupIII
Tunnel CodeD/E
Proper Shipping NameAnisol
Marine PollutantNo

Frequently Asked Questions

What is anisole?

Anisole is an organic chemical compound with the formula C7H8O and CAS number 100-66-3. It is a methyl ether of phenol, consisting of a benzene ring with a methoxy group (-OCH3) attached. With a molecular weight of 108.14 g/mol, anisole appears as a colorless liquid with a characteristic sweet, aromatic odor reminiscent of anise. It is commonly used as a solvent and intermediate in organic synthesis.

What are the physicochemical properties of anisole?

Anisole is a colorless to pale yellow liquid at room temperature with a pleasant, sweet aromatic odor similar to anise or licorice. It has a molecular formula of C7H8O and a molecular weight of 108.14 g/mol. The compound is poorly soluble in water but readily miscible with most organic solvents including alcohols, ethers, and hydrocarbons. It has a relatively low volatility and good chemical stability under normal conditions.

What is anisole used for?

Anisole serves primarily as a solvent in organic synthesis and pharmaceutical manufacturing processes. It is commonly used as an intermediate in the production of perfumes, flavoring agents, and pharmaceuticals due to its aromatic properties. The compound also finds application in the synthesis of other organic compounds, particularly in reactions requiring a stable, non-reactive solvent. Additionally, it is used in the production of polymers and as a component in specialty chemical formulations.

How to handle anisole safely?

Anisole should be handled with standard laboratory safety precautions including wearing appropriate personal protective equipment such as safety goggles, chemical-resistant gloves, and lab coats. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation of vapors. Although anisole presents relatively low toxicity risks, avoid direct skin and eye contact. Ensure proper grounding when transferring the liquid to prevent static electricity buildup.

How to store anisole correctly?

Anisole should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers in secondary containment to prevent spills and maintain storage temperatures below 25°C when possible. Store away from strong oxidizing agents and acids which may cause unwanted reactions. Ensure proper labeling and inventory management, and inspect containers regularly for signs of deterioration or leakage.

What to do in case of contact with anisole?

In case of skin contact with anisole, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15-20 minutes while holding eyelids open. If inhaled, move the person to fresh air and seek medical attention if respiratory irritation occurs. In case of ingestion, do not induce vomiting and seek immediate medical attention.

How to dispose of anisole properly?

Anisole waste must be disposed of according to local, national, and EU waste regulations as a hazardous chemical waste. Do not pour down drains or dispose of with regular waste. Collect waste in appropriate, labeled containers and arrange disposal through licensed hazardous waste disposal companies. Small quantities may be suitable for incineration at authorized facilities. Always consult local environmental authorities for specific disposal requirements and maintain proper waste documentation.

How to transport anisole?

Anisole is classified under ADR transport regulations as Class 3 (Flammable Liquids), Packing Group III. This classification requires appropriate UN-approved packaging and labeling during transport. Vehicles must carry proper documentation including transport documents and safety data sheets. Drivers need ADR training certification for transporting dangerous goods. Ensure packages are properly secured and protected from damage during transit, and follow all applicable national and international transport regulations.

Is anisole subject to specific regulations?

Anisole is subject to standard EU chemical regulations including REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) and CLP (Classification, Labelling and Packaging) regulations. It is not currently listed as a Substance of Very High Concern (SVHC). Manufacturers and importers must comply with REACH registration requirements for quantities above one tonne per year. Users must follow standard industrial chemical handling protocols and maintain safety data sheets.

Where to buy anisole in Europe?

Anisole is available for purchase through OYSI, a European distributor of technical chemicals serving industrial and professional customers across Europe. OYSI provides high-quality anisole with proper documentation including certificates of analysis and safety data sheets. As a specialized chemical distributor, OYSI ensures compliance with European regulations and offers technical support for industrial applications. Contact OYSI directly for availability, specifications, and delivery options in your region.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.