5,7-dichloro-4-(4-fluorophenoxy)quinoline

5,7-dichloro-4-(4-fluorophenoxy)quinoline is a synthetic quinoline derivative with the molecular formula C15H8Cl2FNO and CAS number 124495-18-7. This halogenated organic compound contains both chlorine and fluorine substituents, giving it a molecular weight of 308.1 g/mol. It belongs to the quinoline family of heterocyclic aromatic compounds and is classified as a skin sensitizer with aquatic toxicity properties.

5,7-dichloro-4-(4-fluorophenoxy)quinoline is a solid crystalline compound at room temperature with a molecular weight of 308.1 g/mol. As a halogenated quinoline derivative, it typically appears as a pale yellow to off-white powder. The compound contains both electron-withdrawing chlorine and fluorine atoms, which influence its solubility and stability characteristics. Specific physical properties like melting point and solubility data should be obtained from technical datasheets.

5,7-dichloro-4-(4-fluorophenoxy)quinoline is primarily used as an intermediate in pharmaceutical and fine chemical synthesis. Quinoline derivatives like this compound serve as building blocks for developing antimalarial agents, antibiotics, and other bioactive molecules. It may also find applications in agrochemical research and as a precursor for more complex heterocyclic compounds in medicinal chemistry programs.

5,7-dichloro-4-(4-fluorophenoxy)quinoline must be handled with appropriate personal protective equipment due to its skin sensitizing properties. Wear nitrile gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work in well-ventilated areas or under fume hoods to minimize inhalation exposure. Avoid generating dust and wash hands thoroughly after handling. The compound carries GHS07 pictogram indicating health hazards requiring careful handling procedures.

5,7-dichloro-4-(4-fluorophenoxy)quinoline should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep containers upright and properly labeled with hazard information. Store separately from strong oxidizing agents and bases. Maintain storage temperatures below 25°C and protect from moisture and direct sunlight to ensure product stability and prevent degradation.

Skin contact with 5,7-dichloro-4-(4-fluorophenoxy)quinoline requires immediate removal of contaminated clothing and thorough washing with soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek medical attention. Always consult a physician if symptoms develop or persist.

5,7-dichloro-4-(4-fluorophenoxy)quinoline waste must be disposed of through licensed hazardous waste contractors in accordance with local and European waste regulations. The compound's aquatic toxicity classification requires special handling to prevent environmental contamination. Contact authorized waste management companies for proper collection and disposal. Never discharge into sewers, waterways, or soil. Contaminated packaging should also be treated as hazardous waste and disposed of accordingly.

5,7-dichloro-4-(4-fluorophenoxy)quinoline is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transport purposes. This classification requires appropriate packaging, labeling, and documentation for road transport within Europe. Use UN-approved packaging and ensure proper hazard labels are affixed. Transport documents must include the correct shipping name and classification. Drivers require ADR training for transporting this material.

5,7-dichloro-4-(4-fluorophenoxy)quinoline is subject to REACH regulation for registration and safety data requirements in the EU. Under CLP regulation, it must be classified and labeled as Skin Sensitizer Category 1 and Aquatic Acute/Chronic Category 1. The compound is not currently listed as an SVHC (Substance of Very High Concern). Users must comply with occupational exposure limits and environmental protection measures as specified in safety data sheets.

5,7-dichloro-4-(4-fluorophenoxy)quinoline is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. OYSI provides this compound with complete regulatory documentation including safety data sheets and certificates of analysis. As a professional chemical distributor, OYSI ensures proper packaging, labeling, and compliance with European chemical regulations for safe delivery to qualified industrial and research customers across Europe.