Ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate

Ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate is an organic chemical compound with the molecular formula C17H18O4 and CAS number 132584-17-9. This ester compound has a molecular weight of 286.32 g/mol and features a phenoxyphenyl group attached to a hydroxylated propanoate structure. It is classified as a skin sensitizer and poses environmental hazards to aquatic life, requiring careful handling and environmental protection measures during use and disposal.

Ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate is an organic ester with a molecular formula C17H18O4 and molecular weight of 286.32 g/mol. As an ester compound containing both aromatic and aliphatic components, it likely exhibits moderate polarity and limited water solubility. The presence of the phenoxyphenyl group suggests it may appear as a solid or viscous liquid at room temperature, though specific physical properties like melting point, boiling point, and exact appearance require analytical characterization.

Ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate serves as a chemical intermediate in pharmaceutical and fine chemical synthesis. Its structural features, including the phenoxyphenyl moiety and ester functionality, make it valuable for developing active pharmaceutical ingredients and specialty chemicals. The compound may also find applications in research and development for creating new chemical entities, particularly in medicinal chemistry where such substituted propanoate derivatives are explored for various biological activities.

Ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate must be handled with appropriate personal protective equipment due to its skin sensitization properties (Skin Sens. 1). Wear chemical-resistant gloves, safety glasses, and protective clothing to prevent skin and eye contact. Work in well-ventilated areas or under fume extraction to minimize inhalation exposure. Avoid generating dust or vapors, and implement strict hygiene measures including thorough handwashing after handling to prevent sensitization reactions.

Ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers upright and clearly labeled with hazard information. Store separately from incompatible materials and ensure secondary containment to prevent environmental release due to its aquatic toxicity. Maintain storage areas with appropriate spill response materials and restrict access to trained personnel only.

In case of skin contact with ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for 15-20 minutes and remove contact lenses if present. If irritation persists or allergic reactions develop, seek medical attention promptly. In case of inhalation, move to fresh air and monitor for respiratory symptoms.

Ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate must be disposed of through licensed hazardous waste management facilities due to its aquatic toxicity classification. Never discharge to sewers, waterways, or soil as it poses acute and chronic hazards to aquatic organisms. Collect waste in appropriate containers, label clearly, and arrange collection by authorized waste disposal contractors. Follow local and EU waste regulations (Waste Framework Directive) and maintain disposal documentation for regulatory compliance.

Ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate is classified as ADR Class 9 (Miscellaneous Dangerous Goods), Packing Group III for transportation. Use appropriate UN-specification packaging with proper labeling including Class 9 hazard labels and environmental hazard markings. Transport documents must include the correct shipping name, UN number, and hazard class. Ensure vehicles are equipped for hazardous material transport and drivers hold appropriate ADR certification for Class 9 substances.

Ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate is subject to EU CLP Regulation classification as Skin Sens. 1, Aquatic Acute 1, and Aquatic Chronic 1, requiring appropriate labeling with Warning signal word and GHS07/GHS09 pictograms. It falls under REACH registration requirements for manufacture or import above one tonne annually. The compound is not currently listed as an SVHC (Substance of Very High Concern), but users must comply with occupational exposure limits and environmental protection measures.

Ethyl 2-hydroxy-2-(4-phenoxyphenyl)propanoate is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound with full regulatory compliance documentation including Safety Data Sheets, certificates of analysis, and REACH registration support. As an established chemical distributor, OYSI ensures proper packaging, labeling, and transportation arrangements throughout Europe while maintaining high quality standards for research and industrial applications.