1-hydroxybenzotriazole;hydrate

1-hydroxybenzotriazole hydrate is an organic chemical compound with the molecular formula C6H7N3O2 and CAS number 123333-53-9. This substance belongs to the benzotriazole family and exists as a hydrated form, meaning it contains water molecules in its crystal structure. With a molecular weight of 153.14 g/mol, it is classified as an explosive substance (Expl. 1.3) requiring careful handling and storage procedures.

1-hydroxybenzotriazole hydrate is a crystalline solid compound that typically appears as white to off-white crystals or powder. The substance contains water molecules in its crystal lattice structure, which affects its stability and handling characteristics. It is generally soluble in polar solvents and exhibits explosive properties under certain conditions, requiring appropriate safety measures during handling and storage.

1-hydroxybenzotriazole hydrate is primarily used as a coupling reagent in peptide synthesis and pharmaceutical manufacturing. It serves as an activating agent in the formation of amide bonds during chemical synthesis processes. The compound is also utilized in organic chemistry research laboratories for various synthetic applications and as an intermediate in the production of specialty chemicals and pharmaceutical compounds.

1-hydroxybenzotriazole hydrate requires extreme caution during handling due to its explosive classification (Expl. 1.3). Personnel must wear appropriate personal protective equipment including safety glasses, protective gloves, and lab coats. Work should be conducted in well-ventilated areas or fume hoods, avoiding friction, shock, and heat sources. Only trained personnel should handle this material, and emergency procedures must be readily available.

1-hydroxybenzotriazole hydrate must be stored in a cool, dry place away from heat sources, direct sunlight, and ignition sources due to its explosive properties. The storage area should be well-ventilated and separated from incompatible materials such as strong oxidizers and reducing agents. Containers must be kept tightly closed and properly labeled, with storage limited to minimum quantities required for operations.

In case of skin contact with 1-hydroxybenzotriazole hydrate, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with plenty of clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and seek medical advice. Always consult safety data sheets for specific first aid measures.

1-hydroxybenzotriazole hydrate must be disposed of according to local and national hazardous waste regulations due to its explosive classification. The substance cannot be disposed of in regular waste streams and requires specialized handling by licensed waste disposal companies. Containers must be properly labeled and documented for traceability. Consult local authorities and waste management professionals for specific disposal requirements in your region.

1-hydroxybenzotriazole hydrate is classified under ADR as Class 4.1 (Flammable solids), Packing Group I, indicating high danger level during transport. Special packaging requirements and documentation must be followed, including proper labeling with GHS01 pictogram and "Danger" signal word. Only authorized carriers with appropriate training and equipment should handle transportation, and all ADR regulations for dangerous goods must be strictly observed.

1-hydroxybenzotriazole hydrate is subject to CLP regulation due to its explosive classification and must be labeled with appropriate hazard pictograms and safety information. While not currently listed as a SVHC (Substance of Very High Concern), it falls under REACH regulation requirements for registration and safety data sheet provision. Transportation is regulated under ADR as a dangerous good, requiring compliance with specific packaging and documentation requirements.

1-hydroxybenzotriazole hydrate is available through OYSI, a specialized European distributor of technical chemicals. As an experienced chemical supplier, OYSI can provide this explosive substance with proper documentation, safety data sheets, and compliance with European regulations. Contact OYSI directly for availability, specifications, and ordering information, ensuring your facility meets the necessary safety and regulatory requirements for handling this material.