4-methylpyridine

C6H7N

CAS108-89-4
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
Danger

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Identification

CAS Number
108-89-4
EC Number
203-626-4
UN Number
2313
Index Number
613-037-00-8
PubChem CID
7963

Physical-chemical properties

Molecular Formula
C6H7N
Molar Mass
93.13 g/mol
IUPAC Name
4-methylpyridine

Chemical Identifiers

InChI
InChI=1S/C6H7N/c1-6-2-4-7-5-3-6/h2-5H,1H3
InChI Key
FKNQCJSGGFJEIZ-UHFFFAOYSA-N

Overview

4-methylpyridine (CAS 108-89-4) is a heterocyclic aromatic compound with flammable properties and significant industrial applications as a chemical intermediate. 4-methylpyridine, also known as 4-picoline, is an important pyridine derivative featuring a methyl group attached to the fourth position of the pyridine ring. This colorless to pale yellow liquid belongs to the methylpyridine family and serves as a crucial building block in organic synthesis and pharmaceutical manufacturing. With its molecular formula C6H7N and molecular weight of 93.13 g/mol, this compound exhibits characteristic basic properties due to the nitrogen atom in its aromatic ring structure. The substance presents notable safety considerations, classified as a flammable liquid (Class 3) with acute toxicity properties. It requires careful handling due to its potential for skin and eye irritation, as well as specific target organ toxicity. The compound's hazard profile necessitates appropriate storage conditions and protective measures during industrial processing. Unlike simpler compounds such as butanenitrile or prop-2-enenitrile, 4-methylpyridine's aromatic nature contributes to its stability and specific reactivity patterns. Primary industrial applications include its use as an intermediate in pharmaceutical synthesis, particularly in the production of various therapeutic compounds. The chemical industry also employs 4-methylpyridine in the manufacture of agrochemicals, where its reactive properties enable the formation of complex molecular structures. Additionally, it serves as a precursor in specialty chemical production and as a solvent in specific analytical applications. OYSI maintains reliable supply chains for 4-methylpyridine, ensuring consistent availability for European industrial customers requiring this essential chemical intermediate for their manufacturing processes.

Safety & Classification

Danger
Classification:

Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 3 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H332

Harmful if inhaled.

H311

Toxic in contact with skin.

H302

Harmful if swallowed.

H335

May cause respiratory irritation.

H315

Causes skin irritation.

H319

Causes serious eye irritation.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2313
ADR Class3
Packing GroupIII
Tunnel CodeD/E
Proper Shipping Name4-Picolin
Marine PollutantNo

Frequently Asked Questions

What is 4-methylpyridine?

4-methylpyridine is an organic chemical compound with the molecular formula C6H7N and CAS number 108-89-4. It belongs to the pyridine family, featuring a six-membered aromatic ring containing one nitrogen atom with a methyl group attached at the fourth position. With a molecular weight of 93.13 g/mol, this heterocyclic compound is classified as a flammable liquid with multiple toxicity hazards, requiring careful handling in industrial applications.

What are the physicochemical properties of 4-methylpyridine?

4-methylpyridine is a colorless to pale yellow liquid at room temperature with a characteristic amine-like odor. As a polar organic compound, it exhibits good solubility in water and most organic solvents due to its nitrogen-containing heterocyclic structure. The compound has a relatively low molecular weight of 93.13 g/mol and maintains liquid state under standard conditions, making it suitable for various chemical processes and reactions.

What is 4-methylpyridine used for?

4-methylpyridine serves as an important intermediate in pharmaceutical synthesis and fine chemical manufacturing. It is commonly used in the production of various medications, agrochemicals, and specialty chemicals. The compound acts as a building block for synthesizing more complex molecules, particularly in the development of drugs and pesticides. Its nitrogen-containing structure makes it valuable in coordination chemistry and as a ligand in metal complexes for catalytic applications.

How to handle 4-methylpyridine safely?

4-methylpyridine requires careful handling due to its multiple hazard classifications including flammability and toxicity. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and appropriate respiratory protection when ventilation is inadequate. Work should be conducted in well-ventilated areas or under fume hoods, away from ignition sources. Avoid skin and eye contact, and prevent inhalation of vapors to minimize health risks associated with this hazardous substance.

How to store 4-methylpyridine correctly?

4-methylpyridine must be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames due to its flammable nature. Use tightly sealed containers made of compatible materials and store away from incompatible substances such as strong oxidizers and acids. Temperature should be kept below 25°C when possible, and storage areas should be equipped with appropriate fire suppression systems and spill containment measures.

What to do in case of contact with 4-methylpyridine?

Immediate action is required for any contact with 4-methylpyridine due to its toxicity and irritant properties. For skin contact, remove contaminated clothing and rinse affected area with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with water for 15-20 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical help while providing safety data sheet to medical personnel.

How to dispose of 4-methylpyridine appropriately?

4-methylpyridine disposal must comply with local and national hazardous waste regulations as it cannot be disposed of through regular waste streams. The substance should be collected in appropriate containers and handed over to licensed hazardous waste disposal companies for proper treatment or incineration. Never pour down drains or release into the environment. Consult local environmental authorities for specific disposal requirements and ensure proper documentation of waste disposal activities.

How to transport 4-methylpyridine?

4-methylpyridine is classified under ADR Class 3 (flammable liquids), Packing Group III for transportation purposes. This classification requires specific packaging, labeling, and documentation according to dangerous goods regulations. Vehicles must display appropriate hazard placards, and drivers need dangerous goods training certification. Packages must bear proper shipping names, UN numbers, and hazard labels. Transportation should follow established routes for dangerous goods with appropriate emergency response procedures in place.

Is 4-methylpyridine subject to specific regulations?

4-methylpyridine is subject to various European chemical regulations including REACH registration requirements and CLP classification standards. The substance is not currently listed as an SVHC (Substance of Very High Concern), but its hazard classification requires compliance with workplace safety regulations and proper risk assessment procedures. Users must maintain safety data sheets, implement appropriate risk management measures, and ensure worker training on safe handling practices according to occupational health and safety directives.

Where to buy 4-methylpyridine in Europe?

4-methylpyridine is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across Europe. As an established chemical supplier, OYSI provides quality 4-methylpyridine with proper documentation, safety data sheets, and regulatory compliance support. The company offers reliable supply chains and technical expertise to support customers' specific requirements for this regulated chemical substance while ensuring full compliance with European chemical legislation.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.