4-methylpyridine
C6H7N
Consulting for 4-methylpyridine
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Identification
- CAS Number
- 108-89-4
- EC Number
- 203-626-4
- UN Number
- 2313
- Index Number
- 613-037-00-8
- PubChem CID
- 7963
Physical-chemical properties
- Molecular Formula
- C6H7N
- Molar Mass
- 93.13 g/mol
- IUPAC Name
- 4-methylpyridine
Chemical Identifiers
- InChI
- InChI=1S/C6H7N/c1-6-2-4-7-5-3-6/h2-5H,1H3
- InChI Key
- FKNQCJSGGFJEIZ-UHFFFAOYSA-N
Overview
4-methylpyridine (CAS 108-89-4) is a methylated pyridine derivative with flammable properties and significant industrial applications as a chemical intermediate. This aromatic heterocyclic compound, with the molecular formula C6H7N and a molecular weight of 93.13 g/mol, belongs to the pyridine family of organic chemicals. As a substituted pyridine where a methyl group is attached to the fourth carbon position of the pyridine ring, 4-methylpyridine exhibits distinct chemical and physical properties that make it valuable in various industrial processes. The compound is classified under multiple hazard categories including flammable liquid (Class 3), acute toxicity, and skin and eye irritation, requiring careful handling protocols in accordance with GHS safety standards. From a safety perspective, 4-methylpyridine carries a "Danger" signal word and is associated with pictogrammes GHS02 and GHS06, indicating both fire hazard and acute toxicity risks. Its ADR classification as Class 3 reflects its flammable nature, necessitating appropriate storage and transportation measures. Unlike simpler nitriles such as prop-2-enenitrile or butanenitrile, this pyridine derivative presents additional considerations due to its aromatic heterocyclic structure. The primary industrial applications of 4-methylpyridine include its use as an intermediate in pharmaceutical synthesis, particularly in the production of various drug compounds. It also serves as a building block in agrochemical manufacturing and as a catalyst or co-catalyst in certain chemical reactions. Additionally, the compound finds application in the synthesis of specialty chemicals and advanced materials. OYSI provides reliable access to high-quality 4-methylpyridine for European industrial customers, ensuring consistent supply chains for critical manufacturing processes.
Safety & Classification
Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 3 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
Skin Contact
Measures if substance contacts the skin
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 2313 |
| ADR Class | 3 |
| Packing Group | III |
| Tunnel Code | D/E |
| Proper Shipping Name | 4-Picolin |
| Marine Pollutant | No |
Frequently Asked Questions
What is 4-methylpyridine?
4-methylpyridine is an organic chemical compound with the molecular formula C6H7N and CAS number 108-89-4. It belongs to the pyridine family, featuring a six-membered aromatic ring containing one nitrogen atom with a methyl group attached at the fourth position. With a molecular weight of 93.13 g/mol, this compound is classified as a flammable liquid with toxic properties and requires careful handling due to its hazardous nature.
What are the physicochemical properties of 4-methylpyridine?
4-methylpyridine is a colorless to pale yellow liquid with a characteristic amine-like odor. It has a molecular weight of 93.13 g/mol and maintains liquid form at room temperature. The compound is miscible with water and most organic solvents due to its polar nature from the nitrogen atom. It exhibits basic properties typical of pyridine derivatives and can form salts with acids.
What is 4-methylpyridine used for?
4-methylpyridine is primarily used as an intermediate in pharmaceutical synthesis and chemical manufacturing. It serves as a building block for producing various drugs, agrochemicals, and specialty chemicals. The compound is also utilized in research and development applications, particularly in organic synthesis where pyridine derivatives are required. Its basic properties make it useful as a catalyst or base in certain chemical reactions.
How to handle 4-methylpyridine safely?
4-methylpyridine requires careful handling due to its flammable and toxic nature. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation. Keep away from heat sources, sparks, and open flames. Ensure proper grounding of equipment to prevent static electricity buildup during transfer operations.
How to store 4-methylpyridine correctly?
4-methylpyridine should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition sources. Storage temperature should be kept below 25°C to maintain stability. Keep containers away from incompatible materials such as strong oxidizing agents and acids. Storage areas must be equipped with appropriate fire suppression systems and spill containment measures due to its flammable liquid classification.
What to do in case of contact with 4-methylpyridine?
In case of skin contact with 4-methylpyridine, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush eyes immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after any exposure.
How to dispose of 4-methylpyridine properly?
4-methylpyridine must be disposed of as hazardous waste in accordance with local and national environmental regulations. The compound cannot be disposed of in regular waste streams or sewerage systems. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities may require neutralization or incineration at authorized facilities. Always consult local environmental authorities for specific disposal requirements and maintain proper documentation of waste disposal activities.
How to transport 4-methylpyridine?
4-methylpyridine is classified as ADR Class 3 (flammable liquids), Packing Group III for transportation purposes. It must be packaged in approved containers meeting UN specifications and properly labeled with hazard placards. Transport vehicles must comply with ADR regulations for flammable liquids, including proper ventilation and fire safety equipment. Drivers require appropriate training for hazardous materials transport, and shipping documentation must include proper shipping names and emergency response information.
Is 4-methylpyridine subject to specific regulations?
4-methylpyridine is subject to various European chemical regulations including REACH and CLP classifications. It is not currently listed as an SVHC (Substance of Very High Concern) under REACH. The compound must be classified and labeled according to CLP regulation with appropriate hazard pictogrammes (GHS02, GHS06) and the danger signal word. Users must comply with safety data sheet requirements and may need to register quantities above REACH thresholds for commercial use.
Where to buy 4-methylpyridine in Europe?
4-methylpyridine is available through OYSI, a European distributor specializing in technical chemicals and laboratory reagents. As an established chemical supplier, OYSI can provide 4-methylpyridine in various quantities for industrial, research, and commercial applications. The company ensures compliance with European chemical regulations and provides comprehensive safety documentation. Contact OYSI directly to discuss specific requirements, quantities, and delivery options for your 4-methylpyridine needs.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.