Propan-2-yl 2-chloroacetate

Propan-2-yl 2-chloroacetate is an organic chemical compound with the molecular formula C5H9ClO2 and CAS number 105-48-6. This chloroacetate ester has a molecular weight of 136.58 g/mol and is classified as a hazardous substance with multiple safety concerns including flammability, acute toxicity, and irritant properties. It belongs to the family of chloroacetic acid derivatives commonly used in organic synthesis and chemical manufacturing processes.

Propan-2-yl 2-chloroacetate is typically a colorless to pale yellow liquid at room temperature with a characteristic ester odor. As an organic ester compound, it has limited solubility in water but is readily soluble in most organic solvents such as alcohols, ethers, and hydrocarbons. The compound exhibits flammable properties and can form explosive vapor-air mixtures under certain conditions, requiring careful handling and storage protocols.

Propan-2-yl 2-chloroacetate is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. It serves as a key building block for producing various chemical compounds, particularly in the synthesis of active pharmaceutical ingredients and specialty chemicals. The compound is also utilized in research laboratories for chemical reactions involving chloroacetate chemistry and esterification processes, making it valuable for both industrial and academic applications.

Propan-2-yl 2-chloroacetate must be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing due to its skin and eye irritant properties. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Given its acute toxicity classification, avoid direct contact with skin, eyes, and mucous membranes, and ensure emergency eyewash and safety shower facilities are readily accessible.

Propan-2-yl 2-chloroacetate should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources, ignition sources, and direct sunlight. Keep the substance away from strong oxidizing agents, bases, and incompatible materials that could cause dangerous reactions. Storage areas must comply with flammable liquid storage requirements and be equipped with appropriate fire suppression systems to prevent fire hazards associated with this Class 3 flammable liquid.

In case of skin contact with propan-2-yl 2-chloroacetate, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and seek medical help if breathing difficulties occur. In case of ingestion, do not induce vomiting and seek immediate medical attention.

Propan-2-yl 2-chloroacetate must be disposed of as hazardous waste through licensed waste management companies in accordance with local, national, and European waste regulations. The substance cannot be disposed of in regular waste streams or poured down drains due to its toxic and flammable properties. Containers should be completely emptied and treated as contaminated waste. Always consult local environmental authorities for specific disposal requirements and approved waste treatment facilities.

Propan-2-yl 2-chloroacetate is classified under ADR Class 3 (flammable liquids), Packing Group III for transportation purposes. The substance must be packaged in approved containers and labeled with appropriate hazard markings and UN identification numbers according to international dangerous goods regulations. Transportation vehicles must comply with ADR requirements for flammable liquids, including proper ventilation, fire extinguishing equipment, and driver certification for dangerous goods transport.

Propan-2-yl 2-chloroacetate is subject to various European regulations including REACH registration requirements and CLP classification and labeling regulations. The substance is not currently listed as a Substance of Very High Concern (SVHC) under REACH. However, its classification under multiple hazard classes including acute toxicity and flammability means it must comply with strict handling, storage, and transport regulations across EU member states.

Propan-2-yl 2-chloroacetate is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. OYSI provides reliable supply chain management and technical support for this and other specialty chemicals. As a regulated hazardous substance, purchases typically require proper documentation and may be subject to end-use verification depending on the intended application and local regulations.