4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine

C14H15N3

CAS121552-61-2
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
121552-61-2
UN Number
3077
Index Number
612-242-00-X
PubChem CID
86367

Physical-chemical properties

Molecular Formula
C14H15N3
Molar Mass
225.29 g/mol
IUPAC Name
4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine

Chemical Identifiers

InChI
InChI=1S/C14H15N3/c1-10-9-13(11-7-8-11)17-14(15-10)16-12-5-3-2-4-6-12/h2-6,9,11H,7-8H2,1H3,(H,15,16,17)
InChI Key
HAORKNGNJCEJBX-UHFFFAOYSA-N

Overview

4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine (CAS 121552-61-2) is a substituted pyrimidine compound with cyclopropyl and phenyl functional groups offering specialized chemical reactivity. This organic compound belongs to the pyrimidine family, characterized by its heterocyclic aromatic ring structure substituted with cyclopropyl, methyl, and N-phenyl groups. With a molecular formula of C14H15N3 and molecular weight of 225.29 g/mol, 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine exhibits distinct chemical properties that make it valuable for specialized industrial applications. The compound's structure incorporates a six-membered pyrimidine ring, which is fundamental in many pharmaceutical and agrochemical intermediates. From a safety perspective, this substance requires careful handling due to its classification as a skin sensitizer (Skin Sens. 1) and its potential environmental impact, being classified as acutely and chronically toxic to aquatic life (Aquatic Acute 1; Aquatic Chronic 1). The compound displays GHS07 and GHS09 pictograms with a "Warning" signal word, indicating moderate hazard levels that necessitate appropriate personal protective equipment and environmental precautions during handling and storage. Its ADR Class 9 classification identifies it as a miscellaneous dangerous substance for transport purposes. In industrial applications, 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine serves primarily as a synthetic intermediate in pharmaceutical research and development, particularly in the synthesis of compounds targeting specific biological pathways. The compound also finds application in agrochemical synthesis and specialized organic synthesis processes. Unlike simpler structures such as 5,7-dichloro-4-(4-fluorophenoxy)quinoline, this pyrimidine derivative offers unique reactivity patterns due to its specific substitution pattern. OYSI provides this specialized pyrimidine derivative to support European industrial and research applications, ensuring quality and regulatory compliance for professional users.

Safety & Classification

Warning
Classification:

Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameCyprodinil (ISO)
Marine PollutantNo

Frequently Asked Questions

What is 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine?

4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine is an organic chemical compound with the molecular formula C14H15N3 and CAS number 121552-61-2. This pyrimidine derivative has a molecular weight of 225.29 g/mol and features a cyclopropyl group, methyl substituent, and phenyl amino group attached to the pyrimidine ring. It is classified as a skin sensitizer and poses environmental hazards to aquatic life, requiring careful handling in industrial applications.

What are the physicochemical properties of 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine?

4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine has a molecular formula of C14H15N3 with a molecular weight of 225.29 g/mol. As a substituted pyrimidine compound, it contains nitrogen heteroatoms that influence its chemical behavior. The presence of the cyclopropyl ring, methyl group, and phenyl substituent affects its physical properties including solubility and stability. Specific data on appearance, melting point, and solubility should be obtained from technical datasheets for precise handling requirements.

What is 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine used for?

4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine is primarily used as an intermediate in pharmaceutical and agrochemical synthesis. Its pyrimidine structure makes it valuable for developing bioactive compounds, particularly in medicinal chemistry research. The compound may serve as a building block for creating more complex molecules with therapeutic or agricultural applications. Its specific substitution pattern allows for further chemical modifications in specialized industrial processes requiring precision organic synthesis.

How to handle 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine safely?

4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine must be handled with appropriate personal protective equipment due to its skin sensitizing properties. Wear protective gloves, safety glasses, and protective clothing to prevent skin contact. Ensure adequate ventilation in work areas and avoid generating dust or aerosols. The compound carries GHS07 and GHS09 pictograms, indicating health and environmental hazards. Always follow established safety protocols and consult the safety data sheet before handling.

How to store 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine properly?

4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine should be stored in a cool, dry, well-ventilated area away from incompatible materials. Keep containers tightly closed and protected from moisture and direct sunlight. Due to its environmental hazard classification (Aquatic Acute 1, Aquatic Chronic 1), ensure proper containment to prevent environmental release. Store in original labeled containers and maintain appropriate temperature conditions as specified in the technical documentation to preserve chemical stability.

What to do in case of contact with 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine?

Immediate action is required if contact occurs with 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine due to its skin sensitizing properties. For skin contact, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, rinse immediately with plenty of clean water. If irritation persists or allergic reactions develop, seek medical attention promptly. Always consult the safety data sheet for complete first aid procedures.

How to dispose of 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine appropriately?

4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine must be disposed of through authorized hazardous waste disposal facilities due to its environmental hazard classification. Never discharge into sewers, waterways, or soil as it poses acute and chronic toxicity to aquatic organisms. Contact licensed waste management companies for proper collection and treatment. Follow local and national regulations for hazardous chemical waste disposal, and maintain proper documentation of waste disposal activities for regulatory compliance.

How to transport 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine?

4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine is classified as ADR Class 9 (miscellaneous dangerous goods), Packing Group III for transportation purposes. This classification indicates it presents a relatively lower degree of danger during transport compared to higher packing groups. Proper packaging, labeling, and documentation are required according to ADR regulations. Ensure compliance with international transport regulations and use appropriate packaging materials that meet the specified standards for Class 9 substances.

Is 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine subject to specific regulations?

4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine is subject to standard chemical regulations including REACH registration requirements in Europe and CLP classification for hazard communication. While it is not currently listed as a Substance of Very High Concern (SVHC), it must comply with standard chemical safety regulations due to its skin sensitizing and environmental hazard properties. Users must ensure proper risk assessment, safety data sheet availability, and compliance with occupational health and environmental protection standards.

Where to buy 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine in Europe?

4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides reliable supply of high-quality chemical products to industrial customers across Europe, ensuring proper handling, documentation, and regulatory compliance. As a professional chemical distributor, OYSI can provide technical support, safety documentation, and ensure proper packaging and delivery of this specialized pyrimidine compound for your industrial applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.