4-aminobenzenesulfonic acid

C6H7NO3S

CAS121-57-3
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
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Identification

CAS Number
121-57-3
EC Number
204-482-5
UN Number
Index Number
612-014-00-X
PubChem CID
8479

Physical-chemical properties

Molecular Formula
C6H7NO3S
Molar Mass
173.19 g/mol
IUPAC Name
4-aminobenzenesulfonic acid

Chemical Identifiers

InChI
InChI=1S/C6H7NO3S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H,8,9,10)
InChI Key
HVBSAKJJOYLTQU-UHFFFAOYSA-N

Overview

4-aminobenzenesulfonic acid (CAS 121-57-3) is an aromatic sulfonic acid derivative with amino substitution exhibiting both acidic and basic properties. This organic compound, also known by its IUPAC name 4-aminobenzenesulfonic acid, represents an important class of aromatic sulfonates widely utilized in industrial chemistry. With the molecular formula C6H7NO3S and a molecular weight of 173.19 g/mol, this white to off-white crystalline substance features both sulfonic acid and primary amine functional groups on a benzene ring, making it a versatile intermediate in chemical synthesis. The compound's bifunctional nature stems from the presence of the electron-donating amino group at the para position relative to the electron-withdrawing sulfonic acid group, creating unique reactivity patterns. This structural arrangement allows for various chemical transformations and makes it particularly valuable in the production of dyes, pharmaceuticals, and specialty chemicals. Unlike simpler compounds such as 4-nitrophenol, which contains a nitro group instead of an amino group, 4-aminobenzenesulfonic acid offers different reactivity profiles suitable for specific synthetic pathways. From a safety perspective, this substance is classified under GHS07 pictogram with a "Warning" signal word, indicating moderate hazards including skin irritation (Category 2), eye irritation (Category 2), and skin sensitization (Category 1). Proper handling procedures and personal protective equipment are essential when working with this material. Primary industrial applications include its use as an intermediate in dye manufacturing, particularly in the production of azo dyes, as a building block for pharmaceutical compounds, and in the synthesis of optical brightening agents. The compound's water solubility and stability make it suitable for various aqueous processing conditions. OYSI maintains reliable supply chains for 4-aminobenzenesulfonic acid to support European industrial customers' technical requirements.

Safety & Classification

Warning
Classification:

Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H315

Causes skin irritation.

H319

Causes serious eye irritation.

H317

May cause an allergic skin reaction.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Frequently Asked Questions

What is 4-aminobenzenesulfonic acid?

4-aminobenzenesulfonic acid is an aromatic organic compound with the molecular formula C6H7NO3S and CAS number 121-57-3. This chemical features both an amino group (-NH2) and a sulfonic acid group (-SO3H) attached to a benzene ring, making it an aminosulfonic acid derivative. With a molecular weight of 173.19 g/mol, it serves as an important intermediate in chemical synthesis and industrial applications.

What are the physicochemical properties of 4-aminobenzenesulfonic acid?

4-aminobenzenesulfonic acid typically appears as a white to off-white crystalline solid at room temperature. The compound is highly soluble in water due to its sulfonic acid group, which makes it polar and ionic in nature. It has good thermal stability under normal conditions and exhibits typical aromatic compound characteristics. The presence of both amino and sulfonic acid functional groups gives it amphoteric properties.

What is 4-aminobenzenesulfonic acid used for?

4-aminobenzenesulfonic acid serves primarily as an intermediate in the synthesis of dyes, pigments, and pharmaceutical compounds. It is commonly used in the production of azo dyes and as a building block for various organic syntheses. The compound finds applications in the textile industry, chemical manufacturing, and research laboratories. Its dual functional groups make it valuable for creating complex molecular structures in fine chemical production.

How to handle 4-aminobenzenesulfonic acid safely?

4-aminobenzenesulfonic acid requires careful handling as it can cause skin and eye irritation and may cause skin sensitization. Always wear appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and protective clothing. Work in well-ventilated areas or use local exhaust ventilation to minimize exposure. Avoid direct contact with skin and eyes, and prevent inhalation of dust or vapors during handling operations.

How to store 4-aminobenzenesulfonic acid correctly?

4-aminobenzenesulfonic acid should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly closed when not in use to prevent moisture absorption and contamination. Store away from strong oxidizing agents and incompatible materials. Ensure proper labeling and maintain storage temperatures within recommended ranges to preserve product quality and prevent degradation.

What to do in case of contact with 4-aminobenzenesulfonic acid?

Immediate action is required upon contact with 4-aminobenzenesulfonic acid. For skin contact, remove contaminated clothing and rinse affected area thoroughly with plenty of water for at least 15 minutes. For eye contact, flush immediately with clean water for 15-20 minutes while holding eyelids open. If irritation persists or if inhaled, seek medical attention promptly. Remove person to fresh air if respiratory irritation occurs.

How to dispose of 4-aminobenzenesulfonic acid properly?

4-aminobenzenesulfonic acid disposal must comply with local, national, and EU waste regulations. The compound should be treated as hazardous chemical waste and disposed of through licensed waste management companies. Do not discharge into drains, water courses, or onto the ground. Small quantities may be neutralized under controlled conditions before disposal, but always consult local environmental authorities for specific disposal requirements and approved methods.

How to transport 4-aminobenzenesulfonic acid?

4-aminobenzenesulfonic acid is not classified under ADR dangerous goods regulations for transport, simplifying its shipping requirements. However, proper packaging is still essential to prevent spillage and contamination during transit. Use appropriate containers with secure closures and clear labeling indicating the chemical name and hazard warnings. Follow general chemical transportation guidelines and ensure compliance with carrier-specific requirements for chemical shipments.

Is 4-aminobenzenesulfonic acid subject to specific regulations?

4-aminobenzenesulfonic acid is subject to standard EU chemical regulations including REACH and CLP classification requirements. It is classified as Skin Irritant Category 2, Eye Irritant Category 2, and Skin Sensitizer Category 1, requiring appropriate hazard labeling with GHS07 pictogram and 'Warning' signal word. The substance is not listed as SVHC under REACH, but standard registration and safety data sheet requirements apply for commercial use.

Where to buy 4-aminobenzenesulfonic acid in Europe?

4-aminobenzenesulfonic acid is available through OYSI, a trusted European distributor of specialty chemicals and industrial raw materials. OYSI provides high-quality chemical products with proper documentation, safety data sheets, and regulatory compliance support throughout Europe. Contact OYSI directly to inquire about availability, packaging options, and delivery to your location. Professional technical support is available to assist with product specifications and applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.