3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione

C8H8O3

CAS26266-63-7
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
Danger

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Identification

CAS Number
26266-63-7
EC Number
247-570-9
UN Number
2698
Index Number
607-099-00-5
PubChem CID
6810

Physical-chemical properties

Molecular Formula
C8H8O3
Molar Mass
152.15 g/mol
IUPAC Name
3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione

Chemical Identifiers

InChI
InChI=1S/C8H8O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-2,5-6H,3-4H2
InChI Key
KMOUUZVZFBCRAM-UHFFFAOYSA-N

Overview

3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione (CAS 26266-63-7) is a cyclic anhydride compound with reactive properties used in chemical synthesis and polymer applications. This organic compound, also identified by EC number 247-570-9, belongs to the family of benzofuran derivatives featuring a characteristic anhydride functional group. With a molecular formula of C8H8O3 and molecular weight of 152.15 g/mol, this substance exhibits the typical reactivity patterns associated with cyclic anhydrides, making it valuable for various industrial chemical processes. The compound presents significant safety considerations requiring careful handling protocols. Classified under ADR Class 8 as a corrosive material, it carries GHS pictograms GHS05 and GHS08, indicating serious eye damage potential (Eye Dam. 1), respiratory sensitization properties (Resp. Sens. 1), and skin sensitization risks (Skin Sens. 1). Additionally, it poses chronic aquatic toxicity concerns (Aquatic Chronic 3), necessitating appropriate environmental precautions during use and disposal. In industrial applications, 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione serves primarily as an intermediate in organic synthesis, particularly in the production of specialty polymers and resins. Its anhydride functionality makes it suitable for curing agent formulations and cross-linking applications in advanced materials manufacturing. The compound also finds use in pharmaceutical intermediate synthesis, where its structural features enable specific molecular modifications. Unlike more complex compounds such as 3-dodecyl-1-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrrolidine-2,5-dione, this benzofuran derivative offers simpler handling characteristics while maintaining effective reactivity for targeted applications. OYSI provides reliable access to 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione for European industrial customers requiring consistent quality and technical support for their specialized chemical processes.

Safety & Classification

Danger
Classification:

Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1; Aquatic Chronic 3

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H318

Causes serious eye damage.

H334

May cause allergy or asthma symptoms or breathing difficulties if inhaled.

H317

May cause an allergic skin reaction.

H412

Harmful to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2698
ADR Class8
Packing GroupIII
Tunnel CodeE
Proper Shipping NameTetrahydrophthalsäureanhydride, Maleinsäureanhydrid > 0,05 %, fest
Marine PollutantNo

Frequently Asked Questions

What is 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione?

3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione is an organic chemical compound with the molecular formula C8H8O3 and CAS number 26266-63-7. This bicyclic anhydride derivative has a molecular weight of 152.15 g/mol and belongs to the benzofuran family. It is classified as a hazardous substance requiring careful handling due to its eye-damaging properties and potential to cause respiratory and skin sensitization.

What are the physicochemical properties of 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione?

3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione is a solid organic compound at room temperature with a molecular weight of 152.15 g/mol. As an anhydride derivative, it typically exhibits moderate to good solubility in organic solvents and may react with water under certain conditions. The compound's bicyclic structure contributes to its stability while maintaining reactivity at the anhydride functional groups.

What is 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione used for?

3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione is primarily used as an intermediate in organic synthesis and chemical manufacturing processes. Its anhydride functionality makes it valuable for reactions involving esterification, amidation, and polymer synthesis. The compound serves as a building block in pharmaceutical intermediates, specialty chemicals production, and research applications requiring specific bicyclic anhydride structures.

How to handle 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione safely?

3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione requires strict safety precautions due to its Eye Dam. 1, Resp. Sens. 1, and Skin Sens. 1 classifications. Essential PPE includes chemical-resistant gloves, safety goggles with side shields, and respiratory protection. Work in well-ventilated areas or under fume hoods to prevent inhalation. Avoid direct skin and eye contact, and ensure emergency eyewash stations are readily accessible.

How to store 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione correctly?

3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione should be stored in a cool, dry place away from moisture and incompatible materials. Keep containers tightly sealed in original packaging to prevent contamination and degradation. Store away from strong bases, alcohols, and water sources due to its anhydride nature. Ensure adequate ventilation in storage areas and maintain temperatures below recommended maximums to preserve product integrity.

What to do in case of contact with 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione?

Immediate first aid is crucial for 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione exposure. For eye contact, flush immediately with plenty of water for at least 15 minutes and seek medical attention urgently due to Eye Dam. 1 classification. Remove contaminated clothing and wash affected skin thoroughly with soap and water. If inhaled, move to fresh air immediately. Always seek professional medical advice for any exposure, especially given the sensitization potential.

How to dispose of 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione properly?

3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione waste must be disposed of according to local and European waste regulations as hazardous chemical waste. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Never discharge into drains, soil, or water bodies due to Aquatic Chronic 3 classification. Contaminated packaging should also be treated as hazardous waste and disposed of through authorized channels.

How to transport 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione?

3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione is classified as ADR Class 8 (corrosive substances), Packing Group III for transportation. Packages must comply with UN packaging requirements and display appropriate hazard labels and markings. Transport documents must include proper shipping names and emergency response information. Vehicles must carry appropriate emergency equipment, and drivers require ADR certification for hazardous goods transport.

Is 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione subject to specific regulations?

3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione is subject to REACH regulation in Europe and CLP classification requirements. It carries GHS05 and GHS08 pictograms with 'Danger' signal word, indicating serious health hazards. The substance is not currently listed as SVHC under REACH. Users must comply with occupational exposure limits, safety data sheet requirements, and appropriate risk assessment procedures before use.

Where to buy 3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione in Europe?

3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides reliable supply chains across Europe with proper documentation, safety data sheets, and regulatory compliance support. As a professional chemical distributor, OYSI ensures product quality, appropriate packaging, and technical support for industrial and research applications requiring this specialized anhydride compound.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.