2-bromo-2-nitropropan-1-ol

C3H6BrNO3

CAS24403-04-1
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
24403-04-1
EC Number
407-030-7
UN Number
2923
Index Number
609-062-00-9
PubChem CID
205966

Physical-chemical properties

Molecular Formula
C3H6BrNO3
Molar Mass
183.99 g/mol
IUPAC Name
2-bromo-2-nitropropan-1-ol

Chemical Identifiers

InChI
InChI=1S/C3H6BrNO3/c1-3(4,2-6)5(7)8/h6H,2H2,1H3
InChI Key
NYWJACXVDUOPFY-UHFFFAOYSA-N

Overview

2-bromo-2-nitropropan-1-ol (CAS 24403-04-1) is a halogenated nitro alcohol compound with significant antimicrobial and industrial chemical properties. This specialized organobromine compound, with the molecular formula C3H6BrNO3 and molecular weight of 183.99 g/mol, represents an important class of multifunctional chemicals combining both bromine and nitro functional groups. The presence of these reactive substituents on a propanol backbone gives 2-bromo-2-nitropropan-1-ol unique chemical characteristics that make it valuable for specific industrial applications. The compound exhibits significant hazard properties, classified under multiple acute toxicity categories and requiring careful handling protocols. Its classification includes Acute Toxicity 3 and 4, Specific Target Organ Toxicity (Repeated Exposure) Category 2, Skin Corrosion 1B, and Skin Sensitization Category 1. The substance also presents aquatic toxicity concerns, requiring appropriate environmental safeguards during use and disposal. These safety considerations necessitate proper personal protective equipment and ventilation systems during handling. Industrially, 2-bromo-2-nitropropan-1-ol finds primary application as an antimicrobial preservative in water-based systems, particularly in metalworking fluids and industrial cooling systems. Its biocidal properties make it effective against bacteria, fungi, and algae. Additionally, the compound serves as an intermediate in organic synthesis processes, where its reactive bromine and nitro groups can be utilized for further chemical transformations. Unlike simpler compounds such as pentanedial, which primarily functions as a cross-linking agent, 2-bromo-2-nitropropan-1-ol offers dual functionality through its halogenated and nitrated structure, providing both antimicrobial activity and synthetic versatility. OYSI maintains reliable supply chains for 2-bromo-2-nitropropan-1-ol, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 4 *; STOT RE 2 *; Skin Corr. 1B; Skin Sens. 1; Aquatic Acute 1; Aquati...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H311

Toxic in contact with skin.

H302

Harmful if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H314

Causes severe skin burns and eye damage.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2923
ADR Class8
Packing GroupII
Tunnel CodeE
Proper Shipping Name2-Brom-2-nitropropanol, fest
Marine PollutantNo

Frequently Asked Questions

What is 2-bromo-2-nitropropan-1-ol?

2-bromo-2-nitropropan-1-ol is an organohalogen compound with the molecular formula C3H6BrNO3 and CAS number 24403-04-1. This chemical substance has a molecular weight of 183.99 g/mol and contains both bromine and nitro functional groups attached to a propanol backbone. It is classified as a hazardous substance with multiple danger classifications including acute toxicity, skin corrosion, skin sensitization, and aquatic toxicity. The compound requires careful handling due to its corrosive and toxic properties.

What are the physicochemical properties of 2-bromo-2-nitropropan-1-ol?

2-bromo-2-nitropropan-1-ol is an organic compound that typically appears as a solid or liquid at room temperature, depending on specific conditions. The presence of both polar hydroxyl and nitro groups alongside the bromine atom influences its solubility characteristics and chemical reactivity. The compound's molecular structure with C3H6BrNO3 formula indicates the presence of halogen, alcohol, and nitro functionalities, which affect its physical properties such as boiling point, melting point, and polarity.

What is 2-bromo-2-nitropropan-1-ol used for?

2-bromo-2-nitropropan-1-ol serves primarily as a chemical intermediate in organic synthesis and pharmaceutical manufacturing. The compound is utilized in research laboratories for synthetic chemistry applications, particularly in reactions involving halogenated and nitro-containing intermediates. Its unique structure makes it valuable for developing specialized chemical products and conducting academic research. Industrial applications may include use as a building block for more complex molecules in fine chemical production.

How to handle 2-bromo-2-nitropropan-1-ol safely?

2-bromo-2-nitropropan-1-ol requires strict safety measures due to its corrosive and toxic nature. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, face protection, and appropriate clothing to prevent skin contact. Work must be conducted in well-ventilated areas or under fume hoods to avoid inhalation exposure. Given its Skin Corr. 1B and Acute Tox. classifications, handlers must follow established safety protocols and have emergency procedures readily available.

How to store 2-bromo-2-nitropropan-1-ol correctly?

2-bromo-2-nitropropan-1-ol must be stored in appropriate containers resistant to corrosive substances, away from incompatible materials. Storage areas should be cool, dry, and well-ventilated with secondary containment measures in place. Given its corrosive properties and environmental hazard classification (Aquatic Acute 1), prevent contact with water sources and ensure proper labeling. Storage facilities must comply with local regulations for hazardous substances and include appropriate spill containment measures.

What to do in case of contact with 2-bromo-2-nitropropan-1-ol?

Immediate action is required upon contact with 2-bromo-2-nitropropan-1-ol due to its corrosive nature. For skin contact, immediately remove contaminated clothing and flush affected area with copious amounts of water for at least 15 minutes. In case of eye contact, rinse immediately with water and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical assistance. Always consult the safety data sheet for detailed emergency procedures.

How to dispose of 2-bromo-2-nitropropan-1-ol appropriately?

2-bromo-2-nitropropan-1-ol disposal must comply with local and international hazardous waste regulations due to its toxic and corrosive properties. The substance cannot be disposed of through regular waste streams and requires specialized hazardous waste treatment facilities. Disposal methods may include incineration at authorized facilities or chemical neutralization by qualified waste management companies. Generators must maintain proper documentation and follow chain-of-custody procedures as required by environmental regulations.

How to transport 2-bromo-2-nitropropan-1-ol?

2-bromo-2-nitropropan-1-ol is classified under ADR Class 8 (corrosive substances) with Packing Group II, indicating medium danger level. Transportation requires appropriate corrosive-resistant packaging, proper labeling with GHS pictograms (GHS05, GHS06, GHS08, GHS09), and shipping documentation including dangerous goods declarations. Vehicles must comply with ADR requirements for corrosive substances transport, and drivers need appropriate dangerous goods training. Emergency response information must accompany shipments.

Is 2-bromo-2-nitropropan-1-ol subject to particular regulations?

2-bromo-2-nitropropan-1-ol is subject to various European regulations including REACH registration requirements and CLP classification obligations. The substance is not currently listed as an SVHC (Substance of Very High Concern), but its hazard classifications require compliance with occupational safety regulations and environmental protection measures. Users must maintain safety data sheets, implement risk assessments, and follow workplace exposure limits where established. Import/export may require additional permits depending on jurisdiction.

Where to buy 2-bromo-2-nitropropan-1-ol in Europe?

2-bromo-2-nitropropan-1-ol is available through OYSI, a specialized European distributor of technical chemicals and laboratory reagents. OYSI provides this substance to qualified industrial users, research institutions, and chemical companies across Europe with proper documentation and regulatory compliance. As a hazardous substance requiring specialized handling, purchase is typically restricted to professional users with appropriate safety infrastructure and regulatory compliance capabilities.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.