3,5-dichloro-2,6-difluoropyridin-4-amine

C5H2Cl2F2N2

CAS2840-00-8
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
2840-00-8
EC Number
220-630-1
UN Number
3077
Index Number
612-168-00-8
PubChem CID
76089

Physical-chemical properties

Molecular Formula
C5H2Cl2F2N2
Molar Mass
198.98 g/mol
IUPAC Name
3,5-dichloro-2,6-difluoropyridin-4-amine

Chemical Identifiers

InChI
InChI=1S/C5H2Cl2F2N2/c6-1-3(10)2(7)5(9)11-4(1)8/h(H2,10,11)
InChI Key
BEGINUFBBRTGBH-UHFFFAOYSA-N

Overview

3,5-dichloro-2,6-difluoropyridin-4-amine (CAS 2840-00-8) is a halogenated pyridine derivative with notable chemical reactivity and specialized industrial applications. This fluorinated pyridine compound represents an important class of heterocyclic intermediates widely utilized in pharmaceutical and agrochemical synthesis. With its molecular formula C5H2Cl2F2N2 and molecular weight of 198.98 g/mol, the substance features a pyridine ring system substituted with both chlorine and fluorine atoms, along with an amino functional group. The strategic positioning of these halogen substituents at the 2,3,5,6-positions creates unique electronic properties that make this compound particularly valuable for specialized synthetic transformations. The compound carries a Warning signal word under GHS classification, with pictograms GHS07 and GHS09 indicating potential health hazards and environmental concerns. Its classification as Acute Tox. 4 and Aquatic Chronic 2 requires appropriate handling procedures and environmental protection measures during storage and use. The ADR Class 9 designation categorizes it as a miscellaneous dangerous substance for transportation purposes. Primary industrial applications include its use as a synthetic intermediate in pharmaceutical manufacturing, particularly for developing compounds with improved bioavailability and metabolic stability. The compound also serves as a building block in agrochemical production, where its unique substitution pattern enables the creation of active ingredients with enhanced selectivity. Similar halogenated heterocycles, including compounds like 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1,2,4-triazole derivatives, demonstrate the importance of fluorine incorporation in modern chemical synthesis. OYSI provides reliable access to 3,5-dichloro-2,6-difluoropyridin-4-amine for European industrial customers requiring high-quality heterocyclic intermediates.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; Acute Tox. 4 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name3,5-Dichlor-2,6-difluorpyridin-4-amin
Marine PollutantNo

Frequently Asked Questions

What is 3,5-dichloro-2,6-difluoropyridin-4-amine?

3,5-dichloro-2,6-difluoropyridin-4-amine is a halogenated pyridine derivative with the molecular formula C5H2Cl2F2N2 and CAS number 2840-00-8. This organic compound contains both chlorine and fluorine substituents on a pyridine ring with an amino group at position 4. With a molecular weight of 198.98 g/mol, it is classified as a specialty chemical intermediate used in pharmaceutical and agrochemical synthesis.

What are the physicochemical properties of 3,5-dichloro-2,6-difluoropyridin-4-amine?

3,5-dichloro-2,6-difluoropyridin-4-amine is a solid crystalline compound at room temperature with a molecular weight of 198.98 g/mol. The presence of multiple halogen atoms (chlorine and fluorine) and the pyridine ring structure contribute to its chemical stability and specific reactivity profile. The compound's polarity is influenced by the amino group and halogen substituents, affecting its solubility characteristics in various solvents.

What is 3,5-dichloro-2,6-difluoropyridin-4-amine used for?

3,5-dichloro-2,6-difluoropyridin-4-amine is primarily used as an intermediate in pharmaceutical and agrochemical synthesis. The compound serves as a building block for manufacturing active pharmaceutical ingredients (APIs) and crop protection chemicals. Its multiple halogen substituents and amino group make it valuable for creating complex molecular structures through various chemical transformations in research and development applications.

How to handle 3,5-dichloro-2,6-difluoropyridin-4-amine safely?

3,5-dichloro-2,6-difluoropyridin-4-amine requires careful handling due to its Acute Tox. 4 classification. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. Prevent skin and eye contact, and avoid generating dust or aerosols. Follow good laboratory practices and ensure proper training before handling this material.

How to store 3,5-dichloro-2,6-difluoropyridin-4-amine correctly?

3,5-dichloro-2,6-difluoropyridin-4-amine should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from incompatible materials. Keep containers away from heat sources, direct sunlight, and moisture. Store separately from strong oxidizing agents and bases. Ensure proper labeling with hazard information and maintain an inventory record. Regular inspection of storage containers is recommended to detect any signs of deterioration or leakage.

What to do in case of contact with 3,5-dichloro-2,6-difluoropyridin-4-amine?

In case of skin contact with 3,5-dichloro-2,6-difluoropyridin-4-amine, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with plenty of clean water for 15 minutes and seek medical attention. If inhaled, move the person to fresh air and seek medical advice if symptoms develop. Always consult the safety data sheet for detailed first aid measures.

How to dispose of 3,5-dichloro-2,6-difluoropyridin-4-amine properly?

3,5-dichloro-2,6-difluoropyridin-4-amine must be disposed of in accordance with local, national, and international waste regulations. The compound should not be released into the environment due to its Aquatic Chronic 2 classification. Contact licensed waste disposal companies for proper treatment and disposal. Small quantities may require incineration at high temperatures in specialized facilities. Never dispose of this chemical through regular waste streams or sewage systems.

How to transport 3,5-dichloro-2,6-difluoropyridin-4-amine?

3,5-dichloro-2,6-difluoropyridin-4-amine is classified as ADR Class 9 (Miscellaneous Dangerous Goods), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation during shipping. Use UN-approved packaging and ensure proper hazard labels are affixed. Transport vehicles must comply with ADR regulations, and drivers should have appropriate training. Shipping documents must include the correct technical name and UN number.

Is 3,5-dichloro-2,6-difluoropyridin-4-amine subject to specific regulations?

3,5-dichloro-2,6-difluoropyridin-4-amine is subject to REACH regulation in Europe and must comply with CLP classification requirements. The compound is classified with GHS07 and GHS09 pictograms and carries a Warning signal word. It is not currently listed as a Substance of Very High Concern (SVHC). Users must ensure compliance with registration requirements and follow the extended safety data sheet recommendations for safe use.

Where to buy 3,5-dichloro-2,6-difluoropyridin-4-amine in Europe?

3,5-dichloro-2,6-difluoropyridin-4-amine is available through OYSI, a leading European distributor of specialty chemicals. OYSI provides high-quality chemical products with proper documentation and regulatory compliance throughout Europe. As a specialized distributor, OYSI ensures reliable supply chain management and technical support for customers requiring this halogenated pyridine intermediate. Contact OYSI directly for availability, specifications, and ordering information.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.