[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is a synthetic organic compound with the molecular formula C13H25NO4Si and CAS number 76855-69-1. This chiral molecule features a β-lactam (azetidinone) core structure protected with tert-butyldimethylsilyl and acetate groups. With a molecular weight of 287.43 g/mol, it is classified as a hazardous substance causing eye irritation and skin sensitization.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is an organic silyl ester compound with molecular formula C13H25NO4Si and molecular weight 287.43 g/mol. The presence of silyl protecting groups and acetate functionality suggests moderate lipophilicity and potential sensitivity to hydrolysis. Specific physical properties such as melting point, boiling point, and exact solubility data require laboratory determination or supplier specification sheets for precise values.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is primarily used as an intermediate in pharmaceutical synthesis and organic chemistry research. The β-lactam core structure and protective groups make it valuable for developing β-lactam antibiotics and related pharmaceutical compounds. Its specific stereochemistry (2R,3R,1R configuration) is crucial for synthesizing enantiomerically pure pharmaceutical products. It serves as a building block in medicinal chemistry and fine chemical manufacturing.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate requires careful handling due to its eye irritation and skin sensitization properties. Wear appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and protective clothing. Ensure adequate ventilation in work areas and avoid direct contact with skin and eyes. Handle in a well-ventilated area or under a fume hood to minimize inhalation exposure. Follow standard laboratory safety protocols when working with this compound.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate should be stored in a cool, dry place away from heat sources and direct sunlight. Keep containers tightly sealed to prevent moisture ingress, which could cause hydrolysis of the silyl and acetate protecting groups. Store separately from strong acids, bases, and oxidizing agents. Maintain storage temperature as recommended by the supplier, typically under refrigerated conditions to ensure compound stability and prevent degradation.

Immediate first aid is essential following contact with [(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate. For eye contact, rinse immediately with plenty of clean water for at least 15 minutes and seek medical attention. For skin contact, wash thoroughly with soap and water, and remove contaminated clothing. If inhaled, move to fresh air immediately. Due to its skin sensitization properties, monitor for allergic reactions and consult a physician if symptoms persist or worsen.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate must be disposed of according to local and national hazardous waste regulations. As a hazardous substance, it cannot be disposed of with regular laboratory waste. Contact authorized hazardous waste disposal companies for proper collection and treatment. Ensure proper labeling of waste containers with compound identification and hazard information. Small quantities may be suitable for controlled incineration at high temperatures in specialized facilities.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation. This classification requires appropriate packaging, labeling, and documentation according to ADR regulations for road transport in Europe. Use UN-approved packaging and ensure proper hazard labels are affixed. Transport documentation must include the compound's identification, hazard class, and emergency response information. Follow all applicable dangerous goods transportation regulations.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is not classified as a Substance of Very High Concern (SVHC) under REACH regulation. However, it is subject to CLP regulation classification as Eye Irritant Category 2, Skin Sensitizer Category 1, and Aquatic Chronic Category 2. Suppliers must provide Safety Data Sheets and appropriate hazard labeling with GHS07 and GHS09 pictograms. Users must comply with occupational safety regulations and environmental protection requirements in their respective jurisdictions.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is available through OYSI, a leading European distributor of specialty chemicals and pharmaceutical intermediates. OYSI provides this compound with complete documentation including Safety Data Sheets, Certificates of Analysis, and regulatory compliance information. As a specialized chemical intermediate, availability may be subject to minimum order quantities and lead times. Contact OYSI directly for current pricing, specifications, and delivery options to your location within Europe.