[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is a synthetic organic compound with the molecular formula C13H25NO4Si and CAS number 76855-69-1. This azetidinone derivative has a molecular weight of 287.43 g/mol and features a four-membered β-lactam ring protected with tert-butyldimethylsilyl and acetate groups. The compound is classified as an eye irritant and skin sensitizer under GHS regulations.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is an organosilicon compound with a molecular weight of 287.43 g/mol. As a silyl-protected β-lactam derivative, it typically exists as a solid or viscous liquid at room temperature. The presence of both hydrophobic silyl groups and polar ester functionalities suggests moderate solubility in organic solvents. Specific physical properties should be confirmed through technical documentation.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is primarily used as an intermediate in pharmaceutical synthesis and organic chemistry research. Its β-lactam structure and protective groups make it valuable for developing β-lactam antibiotics and related compounds. The stereospecific configuration (2R,3R,1R) suggests applications in asymmetric synthesis and as a building block for complex pharmaceutical molecules requiring precise stereochemistry.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate requires careful handling due to its eye irritation and skin sensitization properties. Always wear safety goggles, chemical-resistant gloves, and protective clothing when handling. Work in well-ventilated areas or under fume hoods to minimize inhalation exposure. Avoid direct skin and eye contact, and wash hands thoroughly after use. Follow standard laboratory safety protocols for handling sensitizing chemicals.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate should be stored in tightly sealed containers away from light, heat, and moisture. Keep in a cool, dry place with temperatures below 25°C to prevent degradation of the silyl protecting groups. Store away from strong acids, bases, and oxidizing agents. Ensure adequate ventilation in storage areas and maintain proper labeling with hazard warnings for eye irritation and skin sensitization.

Eye contact with [(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate requires immediate flushing with clean water for at least 15 minutes and seeking medical attention. For skin contact, remove contaminated clothing and wash thoroughly with soap and water due to sensitization risk. If inhaled, move to fresh air immediately. In case of ingestion, rinse mouth and seek medical advice. Always have safety data sheets readily available for emergency responders.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate must be disposed of according to local and national hazardous waste regulations. As a potentially harmful chemical to aquatic environments (Aquatic Chronic 2), it cannot be disposed of down drains or in regular waste. Contact licensed hazardous waste disposal companies for proper treatment. Small laboratory quantities may be suitable for high-temperature incineration at authorized facilities.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is classified as ADR Class 9 (miscellaneous dangerous goods), Packing Group III. Transport requires appropriate UN-specification packaging and proper dangerous goods documentation. Packages must display correct hazard labels and shipping names. Ensure carriers are trained in dangerous goods transport and follow ADR regulations for Class 9 substances during road transport within Europe.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is subject to REACH regulation in Europe and must comply with CLP classification requirements. It is classified as Eye Irritant Category 2, Skin Sensitizer Category 1, and Aquatic Chronic Category 2. The substance is not listed as an SVHC (Substance of Very High Concern). Users must follow safety data sheet requirements and workplace exposure guidelines.

[(2R,3R)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxoazetidin-2-yl] acetate is available through OYSI, a specialized European distributor of chemical products. OYSI provides this compound to pharmaceutical companies, research institutions, and chemical manufacturers across Europe. Contact OYSI directly for availability, specifications, and technical support. Ensure proper documentation and compliance with local regulations when ordering this classified chemical substance for your specific applications.