2,4-dichloro-1-fluorobenzene

2,4-dichloro-1-fluorobenzene is an organohalogen compound with the molecular formula C6H3Cl2F and CAS number 1435-48-9. This aromatic compound features a benzene ring substituted with two chlorine atoms at positions 2 and 4, and one fluorine atom at position 1. With a molecular weight of 164.99 g/mol, it belongs to the family of halogenated benzenes and serves as an important intermediate in organic synthesis and pharmaceutical manufacturing.

2,4-dichloro-1-fluorobenzene is typically a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. As a halogenated aromatic compound, it exhibits low water solubility but good solubility in organic solvents such as alcohols, ethers, and hydrocarbons. The presence of multiple halogen substituents affects its boiling point, density, and chemical reactivity compared to unsubstituted benzene, making it a valuable building block in chemical synthesis.

2,4-dichloro-1-fluorobenzene is primarily used as an intermediate in pharmaceutical synthesis, particularly in the production of fluorinated drug compounds. It serves as a key building block in organic chemistry for manufacturing agrochemicals, specialty chemicals, and advanced materials. The compound's unique substitution pattern makes it valuable for synthesizing complex molecules where specific halogen positioning is required for biological activity or chemical functionality.

2,4-dichloro-1-fluorobenzene requires careful handling due to its Acute Tox. 4, STOT RE 2, and Skin Irrit. 2 classifications. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to prevent inhalation. Avoid direct skin and eye contact, and ensure emergency eyewash and shower facilities are readily accessible during handling operations.

2,4-dichloro-1-fluorobenzene should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers in secondary containment to prevent spills and ensure compatibility with container materials. Store away from strong oxidizing agents, bases, and reactive metals. Maintain storage temperatures according to manufacturer specifications and implement proper inventory rotation to ensure product quality and safety.

In case of skin contact with 2,4-dichloro-1-fluorobenzene, immediately remove contaminated clothing and wash affected areas thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet and contact emergency services if symptoms persist or worsen.

2,4-dichloro-1-fluorobenzene must be disposed of in accordance with local, national, and international hazardous waste regulations. Contact licensed hazardous waste disposal companies for proper collection and treatment. Do not discharge into sewers, waterways, or soil due to its Aquatic Chronic 2 classification. Incineration at appropriate high-temperature facilities equipped with emission controls is typically required. Maintain proper documentation of all disposal activities for regulatory compliance and environmental protection.

2,4-dichloro-1-fluorobenzene is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transport purposes. Use appropriate UN-specification packaging and ensure proper labeling with GHS pictograms (GHS07, GHS08, GHS09) and hazard information. Transport documentation must include proper shipping names, hazard classes, and emergency contact information. Only use authorized carriers experienced in handling hazardous chemicals and ensure compliance with all applicable transport regulations.

2,4-dichloro-1-fluorobenzene is subject to REACH regulation requiring registration for manufacture or import above one tonne annually in the EU. It must be classified and labeled according to CLP regulation with Warning signal word and appropriate GHS pictograms. While not currently listed as an SVHC substance, users must comply with occupational exposure limits, environmental discharge restrictions, and proper risk assessment requirements under European chemical legislation.

2,4-dichloro-1-fluorobenzene is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides reliable supply chains, technical support, and regulatory compliance assistance for European customers. As a professional chemical distributor, OYSI ensures proper handling, documentation, and delivery of high-quality 2,4-dichloro-1-fluorobenzene while maintaining full regulatory compliance across European markets.