2,4-dichloro-1-fluorobenzene

2,4-dichloro-1-fluorobenzene is an organohalogen compound with the molecular formula C6H3Cl2F and CAS number 1435-48-9. This aromatic chemical features a benzene ring substituted with two chlorine atoms at positions 2 and 4, and one fluorine atom at position 1. With a molecular weight of 164.99 g/mol, it serves as an important intermediate in organic synthesis and pharmaceutical manufacturing.

2,4-dichloro-1-fluorobenzene is typically a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. As a halogenated aromatic compound, it exhibits low water solubility but good solubility in organic solvents such as alcohols, ethers, and hydrocarbons. The presence of multiple halogens increases its density and boiling point compared to unsubstituted benzene.

2,4-dichloro-1-fluorobenzene serves primarily as a chemical intermediate in pharmaceutical synthesis, agrochemical production, and specialty chemical manufacturing. It is commonly used in the preparation of more complex molecules through nucleophilic substitution reactions, where the halogen atoms can be selectively replaced. The compound finds applications in research laboratories and industrial processes requiring halogenated aromatic building blocks.

Safe handling of 2,4-dichloro-1-fluorobenzene requires appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation. The compound is classified as Acute Tox. 4 and Skin Irrit. 2, requiring careful handling to prevent exposure and potential health effects.

Proper storage of 2,4-dichloro-1-fluorobenzene requires cool, dry, well-ventilated areas away from heat sources, ignition sources, and incompatible materials. Containers should be tightly sealed to prevent evaporation and contamination. Storage areas must be designed to contain spills and protect against environmental release, given its Aquatic Chronic 2 classification. Regular inspection of containers for leaks or deterioration is essential.

In case of skin contact with 2,4-dichloro-1-fluorobenzene, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush with clean water for 15 minutes while keeping eyelids open. If inhaled, move to fresh air immediately. Seek medical attention if irritation persists or if significant exposure has occurred, given its toxicity classification.

Disposal of 2,4-dichloro-1-fluorobenzene must comply with local, national, and international waste regulations as a hazardous chemical waste. The compound cannot be disposed of in regular waste streams and requires treatment by licensed hazardous waste disposal facilities. Incineration at high temperatures in approved facilities is typically the preferred method, ensuring complete destruction while preventing environmental contamination.

Transportation of 2,4-dichloro-1-fluorobenzene falls under ADR Class 9 (Miscellaneous dangerous goods), Packing Group III. This classification requires appropriate packaging, labeling, and documentation according to dangerous goods regulations. Shipments must use UN-approved packaging and display proper hazard labels including GHS pictograms GHS07, GHS08, and GHS09. Transport vehicles must comply with ADR requirements for Class 9 substances.

2,4-dichloro-1-fluorobenzene is subject to various chemical regulations including REACH registration requirements in Europe and CLP classification showing Warning signal word. While not currently listed as an SVHC substance, it must comply with standard chemical safety regulations due to its hazard classifications. Users must maintain safety data sheets, conduct risk assessments, and implement appropriate risk management measures according to applicable legislation.

2,4-dichloro-1-fluorobenzene is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides reliable supply chains for laboratory and industrial quantities, ensuring compliance with European chemical regulations including REACH registration and proper documentation. Contact OYSI directly for availability, specifications, and technical support for your specific application requirements.