2,4-dichloro-1-(4-nitrophenoxy)benzene

C12H7Cl2NO3

CAS1836-75-5
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
1836-75-5
EC Number
217-406-0
UN Number
3077
Index Number
609-040-00-9
PubChem CID
15787

Physical-chemical properties

Molecular Formula
C12H7Cl2NO3
Molar Mass
284.09 g/mol
IUPAC Name
2,4-dichloro-1-(4-nitrophenoxy)benzene

Chemical Identifiers

InChI
InChI=1S/C12H7Cl2NO3/c13-8-1-6-12(11(14)7-8)18-10-4-2-9(3-5-10)15(16)17/h1-7H
InChI Key
XITQUSLLOSKDTB-UHFFFAOYSA-N

Overview

2,4-dichloro-1-(4-nitrophenoxy)benzene (CAS 1836-75-5) is an organochlorine compound with nitrophenoxy functionality used in specialized chemical synthesis applications. This aromatic compound, with the molecular formula C12H7Cl2NO3 and a molecular weight of 284.09 g/mol, represents a significant chemical intermediate in industrial organic synthesis. The presence of both chlorine substituents and a nitrophenoxy group provides unique reactivity patterns that make it valuable for specific synthetic pathways. Its structural complexity, featuring dichlorosubstituted benzene linked through an ether bond to a nitrobenzene moiety, enables selective chemical transformations in pharmaceutical and agrochemical manufacturing processes. The compound exhibits significant hazard properties requiring careful handling protocols. Classified under GHS pictograms GHS08, GHS07, and GHS09 with the signal word "Danger," it presents carcinogenic (Category 1B) and reproductive toxicity (Category 1B) concerns. Additionally, it shows acute toxicity Category 4 properties and severe aquatic toxicity with both acute and chronic environmental impact classifications. Transportation falls under ADR Class 9, reflecting its status as a miscellaneous dangerous substance requiring specialized shipping procedures. Industrial applications include use as a chemical intermediate in pharmaceutical synthesis and as a precursor in agrochemical development. The compound's reactivity profile makes it particularly suitable for nucleophilic substitution reactions and coupling processes. Its relationship to substances like 4-[(4-amino-3-chlorophenyl)methyl]-2-chloroaniline demonstrates its role in complex aromatic synthesis pathways, where selective functionalization is essential. OYSI maintains reliable supply chains for 2,4-dichloro-1-(4-nitrophenoxy)benzene, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Danger
Classification:

Carc. 1B; Repr. 1B; Acute Tox. 4 *; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H302

Harmful if swallowed.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameNitrofen (ISO)
Marine PollutantNo

Frequently Asked Questions

What is 2,4-dichloro-1-(4-nitrophenoxy)benzene?

2,4-dichloro-1-(4-nitrophenoxy)benzene is an organochlorine compound with the molecular formula C12H7Cl2NO3 and CAS number 1836-75-5. This chemical substance has a molecular weight of 284.09 g/mol and belongs to the family of chlorinated aromatic compounds containing both nitro and phenoxy functional groups. It is classified as a highly hazardous substance with carcinogenic and reproductive toxicity properties, requiring strict safety measures during handling and use.

What are the physicochemical properties of 2,4-dichloro-1-(4-nitrophenoxy)benzene?

2,4-dichloro-1-(4-nitrophenoxy)benzene is a solid organic compound at room temperature with a molecular weight of 284.09 g/mol. As an aromatic chlorinated compound containing nitro groups, it typically appears as a crystalline solid with limited water solubility due to its hydrophobic aromatic structure. The presence of chlorine and nitro substituents affects its chemical stability and reactivity. Specific physical properties such as melting point and exact solubility values should be verified through technical data sheets.

What is 2,4-dichloro-1-(4-nitrophenoxy)benzene used for?

2,4-dichloro-1-(4-nitrophenoxy)benzene is primarily used as an intermediate in organic synthesis and pharmaceutical research applications. Its aromatic structure with chlorine and nitro functional groups makes it valuable for developing specialized chemical compounds. Due to its high toxicity classification (Carc. 1B, Repr. 1B), its use is restricted to professional applications with appropriate safety controls. Industrial applications may include synthesis of more complex organic molecules in controlled laboratory or manufacturing environments.

How to handle 2,4-dichloro-1-(4-nitrophenoxy)benzene safely?

2,4-dichloro-1-(4-nitrophenoxy)benzene requires maximum safety precautions due to its carcinogenic and reproductive toxicity properties. Essential protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas or fume hoods. Work surfaces should be covered with absorbent materials, and all handling should occur in designated areas away from food and beverages. Personnel must be trained in hazardous material handling procedures and emergency response protocols before working with this substance.

How to store 2,4-dichloro-1-(4-nitrophenoxy)benzene correctly?

2,4-dichloro-1-(4-nitrophenoxy)benzene must be stored in a cool, dry, well-ventilated area away from incompatible materials and ignition sources. Containers should be tightly sealed and properly labeled with hazard warnings. Storage areas must be restricted to authorized personnel only due to the substance's carcinogenic properties. Secondary containment systems are recommended to prevent environmental release. The storage facility should comply with local regulations for carcinogenic substances and include appropriate fire suppression and spill containment measures.

What to do in case of contact with 2,4-dichloro-1-(4-nitrophenoxy)benzene?

Immediate action is required for any contact with 2,4-dichloro-1-(4-nitrophenoxy)benzene due to its high toxicity. For skin contact, remove contaminated clothing and rinse affected area with plenty of water for at least 15 minutes. In case of eye contact, flush thoroughly with water and seek immediate medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek emergency medical care. Always inform medical personnel about the specific substance and its hazardous properties.

How to dispose of 2,4-dichloro-1-(4-nitrophenoxy)benzene appropriately?

2,4-dichloro-1-(4-nitrophenoxy)benzene must be disposed of as hazardous waste through licensed waste management companies specializing in carcinogenic substances. The compound cannot be disposed of in regular waste streams due to its classification as Carc. 1B and its aquatic toxicity. Waste containers must be properly labeled and stored in secure areas until collection. Disposal methods typically include high-temperature incineration in specialized facilities. All disposal activities must comply with local, national, and European waste regulations for hazardous substances.

How to transport 2,4-dichloro-1-(4-nitrophenoxy)benzene?

2,4-dichloro-1-(4-nitrophenoxy)benzene is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. Packages must be properly labeled with appropriate hazard markings and transport documents must accompany shipments. Vehicles and containers must meet ADR requirements for Class 9 substances. Drivers must hold valid ADR certification and carry emergency response information. Special precautions are needed due to the substance's carcinogenic properties, requiring additional safety documentation and handling protocols during transport.

Is 2,4-dichloro-1-(4-nitrophenoxy)benzene subject to specific regulations?

2,4-dichloro-1-(4-nitrophenoxy)benzene is subject to extensive European chemical regulations including REACH registration requirements and CLP classification as a carcinogenic and reproductive toxicant. The substance carries GHS08, GHS07, and GHS09 pictograms with 'Danger' signal word. While not currently listed as an SVHC, its Carc. 1B and Repr. 1B classifications mean it may face future restrictions. Companies must comply with occupational exposure limits, provide safety data sheets, and implement risk management measures for worker and environmental protection.

Where to buy 2,4-dichloro-1-(4-nitrophenoxy)benzene in Europe?

2,4-dichloro-1-(4-nitrophenoxy)benzene is available through OYSI, a specialized European distributor of technical chemicals. As a professional chemical supplier, OYSI ensures compliance with all regulatory requirements including REACH registration and proper documentation. Due to the substance's hazardous classification, purchases are restricted to qualified professional users with appropriate safety infrastructure. OYSI provides technical support, safety data sheets, and ensures proper packaging and transport according to ADR Class 9 requirements for safe delivery across Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.