2-methylpyridine

C6H7N

CAS109-06-8
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
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Identification

CAS Number
109-06-8
EC Number
203-643-7
UN Number
2313
Index Number
613-036-00-2
PubChem CID
7975

Physical-chemical properties

Molecular Formula
C6H7N
Molar Mass
93.13 g/mol
IUPAC Name
2-methylpyridine

Chemical Identifiers

InChI
InChI=1S/C6H7N/c1-6-4-2-3-5-7-6/h2-5H,1H3
InChI Key
BSKHPKMHTQYZBB-UHFFFAOYSA-N

Overview

2-methylpyridine (CAS 109-06-8) is a heterocyclic organic compound with flammable properties and moderate toxicity profile used in chemical synthesis applications. This nitrogen-containing aromatic compound, also known as 2-picoline, belongs to the methylpyridine family and serves as an important intermediate in organic chemistry. With its molecular formula C6H7N and molecular weight of 93.13 g/mol, 2-methylpyridine exhibits characteristic properties of substituted pyridines while maintaining distinct reactivity due to the methyl group positioned at the 2-carbon of the pyridine ring. The compound presents as a colorless to pale yellow liquid with a distinctive odor typical of pyridine derivatives. Safety considerations are paramount when handling 2-methylpyridine, as it is classified as a flammable liquid (Category 3) and exhibits acute toxicity properties requiring careful storage and handling procedures. The substance carries GHS02 and GHS07 pictograms with a "Warning" signal word, indicating its potential for fire hazards and health risks including eye irritation and specific target organ toxicity. In industrial applications, 2-methylpyridine finds primary use as a chemical intermediate in pharmaceutical synthesis, agrochemical production, and specialty chemical manufacturing. Its reactivity profile makes it valuable for producing various nitrogen-containing compounds and heterocyclic derivatives. The compound shares certain applications with related aromatic compounds, though its specific pyridine structure provides unique synthetic pathways compared to compounds like 1,4-xylene. Transportation regulations classify 2-methylpyridine under ADR Class 3, requiring appropriate hazardous materials handling protocols during shipping and storage. OYSI provides reliable access to high-quality 2-methylpyridine for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Warning
Classification:

Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Eye Irrit. 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H335

May cause respiratory irritation.

H319

Causes serious eye irritation.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2313
ADR Class3
Packing GroupIII
Tunnel CodeD/E
Proper Shipping Name2-Picolin
Marine PollutantNo

Frequently Asked Questions

What is 2-methylpyridine?

2-methylpyridine is an organic heterocyclic compound with the molecular formula C6H7N and CAS number 109-06-8. It belongs to the pyridine family, where a methyl group is attached to the second carbon of the pyridine ring. With a molecular weight of 93.13 g/mol, this colorless to pale yellow liquid serves as an important intermediate in chemical synthesis and pharmaceutical manufacturing.

What are the physicochemical properties of 2-methylpyridine?

2-methylpyridine is a colorless to pale yellow liquid at room temperature with a characteristic amine-like odor. It has a molecular weight of 93.13 g/mol and is miscible with water and most organic solvents. The compound exhibits basic properties due to the nitrogen atom in the pyridine ring and has a relatively low flash point, making it a flammable liquid.

What is 2-methylpyridine used for?

2-methylpyridine is primarily used as an intermediate in pharmaceutical synthesis, particularly in the production of antihistamines and other medicinal compounds. It serves as a building block in organic synthesis for manufacturing agrochemicals, dyes, and rubber chemicals. The compound is also employed as a solvent and catalyst in various chemical reactions within industrial processes.

How to handle 2-methylpyridine safely?

2-methylpyridine requires careful handling due to its flammable nature and toxicity. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. Keep away from heat sources, sparks, and open flames. Use non-sparking tools and ensure proper grounding to prevent static electricity buildup.

How to store 2-methylpyridine correctly?

2-methylpyridine must be stored in a cool, dry, well-ventilated area away from heat sources and ignition sources. Keep containers tightly closed and store in original packaging or approved chemical storage containers. Maintain storage temperature below 25°C and protect from direct sunlight. Store separately from strong oxidizing agents, acids, and incompatible materials to prevent dangerous reactions.

What to do in case of contact with 2-methylpyridine?

In case of skin contact with 2-methylpyridine, immediately remove contaminated clothing and wash the affected area with plenty of soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for 15 minutes and seek medical attention. If inhaled, move to fresh air and seek medical help if symptoms persist. In case of ingestion, do not induce vomiting and seek immediate medical attention.

How to dispose of 2-methylpyridine properly?

2-methylpyridine must be disposed of according to local and national hazardous waste regulations. The substance cannot be disposed of in regular waste streams due to its toxicity and flammable properties. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities may require special collection procedures, while larger amounts need professional hazardous waste management services.

How to transport 2-methylpyridine?

2-methylpyridine is classified as ADR Class 3 (flammable liquids), Packing Group III for transportation. It must be shipped in approved UN specification packaging with proper labeling including flammable liquid hazard labels. Transport vehicles must comply with ADR regulations for Class 3 substances, including appropriate placarding, documentation, and driver certification requirements for hazardous materials transport.

Is 2-methylpyridine subject to specific regulations?

2-methylpyridine is subject to REACH regulation in Europe and must comply with CLP classification requirements. It is classified with multiple hazard statements including flammable liquid and acute toxicity warnings. The substance is not currently listed as a Substance of Very High Concern (SVHC). Users must follow proper risk assessment procedures and implement appropriate risk management measures according to safety data sheets.

Where to buy 2-methylpyridine in Europe?

2-methylpyridine is available through OYSI, a trusted European distributor of specialty chemicals. OYSI provides high-quality 2-methylpyridine with proper documentation, safety data sheets, and regulatory compliance for European markets. As an established chemical distributor, OYSI ensures reliable supply chains and technical support for industrial customers requiring this specialized chemical intermediate across Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.