2-methylpyridine

C6H7N

CAS109-06-8
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
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Identification

CAS Number
109-06-8
EC Number
203-643-7
UN Number
2313
Index Number
613-036-00-2
PubChem CID
7975

Physical-chemical properties

Molecular Formula
C6H7N
Molar Mass
93.13 g/mol
IUPAC Name
2-methylpyridine

Chemical Identifiers

InChI
InChI=1S/C6H7N/c1-6-4-2-3-5-7-6/h2-5H,1H3
InChI Key
BSKHPKMHTQYZBB-UHFFFAOYSA-N

Overview

2-methylpyridine (CAS 109-06-8) is a heterocyclic organic compound featuring a pyridine ring with a methyl substituent at the 2-position. This colorless to pale yellow liquid, also known as α-picoline, belongs to the methylpyridine family of compounds and serves as an important intermediate in various chemical synthesis processes. With a molecular formula of C6H7N and molecular weight of 93.13 g/mol, 2-methylpyridine exhibits characteristic properties of both aromatic heterocycles and basic nitrogen-containing compounds. The compound displays a distinctive amine-like odor and demonstrates moderate solubility in water while being miscible with most organic solvents. From a safety perspective, 2-methylpyridine is classified as a flammable liquid (Category 3) and presents acute toxicity hazards through multiple exposure routes. The compound requires careful handling due to its potential for eye irritation and specific target organ toxicity. Its flammable nature necessitates appropriate storage conditions away from ignition sources, with transport classification under ADR Class 3 regulations. Industrial applications of 2-methylpyridine primarily center on its role as a chemical intermediate in pharmaceutical synthesis, particularly in the production of antihistamines and other therapeutic compounds. The compound also finds use in agrochemical manufacturing and as a catalyst or solvent in specialized chemical reactions. Unlike structurally different compounds such as 1,4-xylene, 2-methylpyridine's nitrogen heteroatom provides unique reactivity patterns that make it valuable in heterocyclic chemistry applications. OYSI maintains reliable supply chains for 2-methylpyridine, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Warning
Classification:

Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Eye Irrit. 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H335

May cause respiratory irritation.

H319

Causes serious eye irritation.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2313
ADR Class3
Packing GroupIII
Tunnel CodeD/E
Proper Shipping Name2-Picolin
Marine PollutantNo

Frequently Asked Questions

What is 2-methylpyridine?

2-methylpyridine is an organic chemical compound with the molecular formula C6H7N and CAS number 109-06-8. It belongs to the pyridine family, characterized by a six-membered aromatic ring containing one nitrogen atom with a methyl group attached at the second position. With a molecular weight of 93.13 g/mol, this compound is classified as a flammable liquid and poses moderate toxicity risks, requiring careful handling in industrial applications.

What are the physicochemical properties of 2-methylpyridine?

2-methylpyridine is a colorless to pale yellow liquid with a characteristic pyridine-like odor. It is miscible with water and most organic solvents due to its polar nitrogen atom. The compound has a boiling point around 129°C and is lighter than water. It exhibits basic properties due to the nitrogen atom's lone pair of electrons, making it capable of forming salts with acids and participating in various chemical reactions.

What is 2-methylpyridine used for?

2-methylpyridine is primarily used as an intermediate in pharmaceutical synthesis and agrochemical production. It serves as a building block for manufacturing various drugs, pesticides, and herbicides. The compound is also utilized in the production of specialty chemicals, dyes, and rubber accelerators. Its basic properties make it valuable as a catalyst or co-catalyst in certain organic reactions, particularly in the synthesis of complex organic molecules in fine chemical manufacturing.

How to handle 2-methylpyridine safely?

2-methylpyridine requires careful handling due to its flammable and toxic properties. Workers must wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Ensure adequate ventilation to prevent vapor accumulation and avoid ignition sources. Handle in areas equipped with emergency shower and eyewash facilities. Use grounding equipment when transferring the substance to prevent static electricity buildup, and always work with proper fire suppression systems nearby.

How to store 2-methylpyridine correctly?

2-methylpyridine should be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames. Use tightly sealed containers made of compatible materials and store away from incompatible substances such as strong oxidizers and acids. Maintain storage temperatures below 25°C and ensure proper secondary containment. Storage areas must be equipped with fire suppression systems and spill control measures, with access restricted to trained personnel only.

What to do in case of contact with 2-methylpyridine?

Immediate action is required upon contact with 2-methylpyridine. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after any significant exposure.

How to dispose of 2-methylpyridine appropriately?

2-methylpyridine must be disposed of according to local and national hazardous waste regulations. The substance cannot be disposed of in regular waste streams due to its toxic and flammable properties. Contact licensed hazardous waste disposal companies for proper treatment, which may include incineration at high temperatures or specialized chemical treatment. Never pour down drains or sewers. Contaminated containers should also be treated as hazardous waste and disposed of through appropriate channels.

How to transport 2-methylpyridine?

2-methylpyridine is classified as ADR Class 3 (Flammable Liquids), Packing Group III for transportation purposes. It must be transported in UN-approved packaging with proper labeling including flammable liquid hazard labels. Vehicles must be equipped with appropriate fire extinguishing equipment and drivers must hold valid dangerous goods certifications. Transport documents must include emergency response information, and routes should avoid populated areas where possible. Ensure proper segregation from incompatible materials during transport.

Is 2-methylpyridine subject to specific regulations?

2-methylpyridine is subject to various European regulations including REACH registration requirements for importers and manufacturers. Under CLP regulation, it must be classified and labeled with Warning signal word and appropriate GHS pictograms (GHS02, GHS07). The substance is not currently listed as a SVHC (Substance of Very High Concern). Companies handling this chemical must comply with occupational safety regulations and may need to implement risk management measures based on usage quantities and exposure scenarios.

Where to buy 2-methylpyridine in Europe?

2-methylpyridine is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides reliable supply chains across Europe with proper documentation including safety data sheets and certificates of analysis. As a professional chemical distributor, OYSI ensures compliance with all relevant regulations and provides technical support for safe handling and application guidance. Contact OYSI directly for availability, specifications, and delivery options tailored to your specific requirements and location within Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.