2-methyl-5-nitroaniline

C7H8N2O2

CAS99-55-8
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
Danger

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Identification

CAS Number
99-55-8
EC Number
202-765-8
UN Number
2660
Index Number
612-210-00-5
PubChem CID
7444

Physical-chemical properties

Molecular Formula
C7H8N2O2
Molar Mass
152.15 g/mol
IUPAC Name
2-methyl-5-nitroaniline

Chemical Identifiers

InChI
InChI=1S/C7H8N2O2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4H,8H2,1H3
InChI Key
DSBIJCMXAIKKKI-UHFFFAOYSA-N

Overview

2-methyl-5-nitroaniline (CAS 99-55-8) is an aromatic amine compound with nitro and methyl substituents on the benzene ring. This chemical substance, also identified by EC number 202-765-8, belongs to the family of nitroanilines and serves as an important intermediate in organic synthesis. With a molecular formula of C7H8N2O2 and molecular weight of 152.15 g/mol, 2-methyl-5-nitroaniline exhibits characteristic properties of substituted anilines while presenting specific safety considerations due to its nitro functionality. The compound's structure features both electron-withdrawing nitro groups and electron-donating methyl groups, creating unique reactivity patterns that make it valuable in various chemical transformations. The substance requires careful handling protocols due to its classification as a Category 2 carcinogen and Category 3 acute toxicity across multiple exposure routes. Safety measures must address the GHS08 and GHS06 pictogram warnings, with proper personal protective equipment and ventilation systems essential during use. Transport regulations classify this material under ADR Class 6.1, reflecting its toxic properties and requiring appropriate shipping documentation and packaging. Primary industrial applications include its use as an intermediate in the synthesis of dyes, pigments, and pharmaceutical compounds. The chemical industry utilizes 2-methyl-5-nitroaniline in the production of azo dyes and as a building block for more complex aromatic molecules. Unlike simpler compounds such as N-methylaniline, this substituted derivative offers specific structural features that enable targeted synthetic pathways in specialty chemical manufacturing. OYSI provides 2-methyl-5-nitroaniline to European industrial customers with comprehensive technical support and regulatory documentation to ensure safe and compliant use across various applications.

Safety & Classification

Danger
Classification:

Carc. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Aquatic Chronic 3

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H412

Harmful to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2660
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Name5-Nitro-o-toluidin, fest
Marine PollutantNo

Frequently Asked Questions

What is 2-methyl-5-nitroaniline?

2-methyl-5-nitroaniline is an aromatic amine compound with the molecular formula C7H8N2O2 and CAS number 99-55-8. This organic chemical belongs to the nitroaniline family, featuring both methyl and nitro functional groups attached to an aniline ring. With a molecular weight of 152.15 g/mol, it is classified as a hazardous substance due to its carcinogenic properties and acute toxicity, requiring careful handling in industrial applications.

What are the physicochemical properties of 2-methyl-5-nitroaniline?

2-methyl-5-nitroaniline is typically a solid crystalline compound at room temperature, appearing as yellow to orange crystals or powder. The substance has a molecular weight of 152.15 g/mol and contains both amino and nitro functional groups, making it moderately polar. It exhibits limited water solubility but dissolves well in organic solvents such as ethanol, acetone, and benzene. The compound may darken upon exposure to light and air.

What is 2-methyl-5-nitroaniline used for?

2-methyl-5-nitroaniline is primarily used as an intermediate in the synthesis of dyes, pigments, and pharmaceuticals. It serves as a key building block in the production of azo dyes and various organic colorants used in textile, printing, and coating industries. The compound is also utilized in the manufacture of certain pharmaceutical compounds and as a chemical intermediate in organic synthesis processes requiring substituted aniline derivatives.

How to handle 2-methyl-5-nitroaniline safely?

2-methyl-5-nitroaniline requires strict safety measures due to its carcinogenic and acute toxic properties. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation. Avoid skin and eye contact, and ensure no eating, drinking, or smoking in work areas. Emergency washing facilities must be readily available.

How to store 2-methyl-5-nitroaniline correctly?

2-methyl-5-nitroaniline should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers upright and clearly labeled with hazard information. Store separately from incompatible materials such as strong oxidizers, acids, and bases. Ensure storage areas have appropriate spill containment measures and restrict access to authorized personnel only. Regular container inspection is recommended.

What to do in case of contact with 2-methyl-5-nitroaniline?

Immediate action is required upon contact with 2-methyl-5-nitroaniline. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes. If inhaled, move person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult emergency services and provide safety data sheet information.

How to dispose of 2-methyl-5-nitroaniline appropriately?

2-methyl-5-nitroaniline must be disposed of as hazardous waste according to local and national regulations. The substance cannot be disposed of in regular waste streams due to its carcinogenic and toxic properties. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities may require special collection procedures. Always consult local environmental authorities for specific disposal requirements and maintain proper documentation of waste disposal activities.

How to transport 2-methyl-5-nitroaniline?

2-methyl-5-nitroaniline is classified under ADR Class 6.1 (Toxic substances) Packing Group III for transportation. The substance requires appropriate hazardous goods packaging, labeling, and documentation during transport. Vehicles must display proper placards and carry emergency response information. Drivers need hazardous materials training certification. Ensure packages are secure, properly sealed, and marked with correct shipping names and hazard labels according to dangerous goods regulations.

Is 2-methyl-5-nitroaniline subject to specific regulations?

2-methyl-5-nitroaniline is subject to various European regulations including REACH registration requirements and CLP classification as Carcinogenic Category 2. The substance requires safety data sheets and appropriate hazard labeling with GHS pictograms GHS06 and GHS08. Workplace exposure limits may apply, and special handling procedures are mandatory due to its carcinogenic classification. Companies using this substance must comply with occupational health and safety regulations and environmental protection requirements.

Where to buy 2-methyl-5-nitroaniline in Europe?

2-methyl-5-nitroaniline is available through OYSI, a specialized European distributor of industrial chemicals. As a professional chemical supplier, OYSI provides this substance with complete regulatory documentation including safety data sheets and certificates of analysis. The company ensures compliance with European chemical regulations and offers technical support for safe handling and application. Contact OYSI directly for availability, specifications, and regulatory information specific to your application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.