2-fluoro-6-(trifluoromethyl)pyridine

2-fluoro-6-(trifluoromethyl)pyridine is a fluorinated pyridine derivative with the molecular formula C6H3F4N and CAS number 94239-04-0. This organic compound features a pyridine ring substituted with a fluoro group at position 2 and a trifluoromethyl group at position 6. With a molecular weight of 165.09 g/mol, it belongs to the class of halogenated heterocycles and is classified as a flammable liquid with moderate toxicity hazards.

2-fluoro-6-(trifluoromethyl)pyridine is a liquid at room temperature with characteristic properties typical of fluorinated pyridines. The compound exhibits high chemical stability due to the strong C-F bonds and the electron-withdrawing effects of the fluorine substituents. Its polarity and solubility characteristics are influenced by the fluorine atoms, making it less polar than unsubstituted pyridine. The trifluoromethyl group significantly affects its volatility and lipophilicity properties.

2-fluoro-6-(trifluoromethyl)pyridine serves primarily as an intermediate in pharmaceutical and agrochemical synthesis. The compound is valuable in medicinal chemistry for developing fluorinated drug molecules, where fluorine substitution often enhances bioavailability and metabolic stability. It is also used in the synthesis of specialty chemicals and as a building block for advanced materials. The unique electronic properties conferred by the fluorine substituents make it particularly useful in fine chemical manufacturing.

2-fluoro-6-(trifluoromethyl)pyridine requires careful handling due to its flammable and toxic properties. Operators must wear appropriate personal protective equipment including chemical-resistant gloves, safety glasses, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Keep away from ignition sources, heat, and sparks. Use non-sparking tools and ensure proper grounding to prevent static electricity buildup during transfers.

2-fluoro-6-(trifluoromethyl)pyridine must be stored in a cool, dry, well-ventilated area away from heat sources and ignition points. Keep containers tightly closed in original packaging and store below 25°C to maintain stability. Ensure segregation from incompatible materials such as strong oxidizers and bases. Storage areas should be equipped with appropriate fire suppression systems and spill containment measures. Regular inspection of containers for integrity is recommended to prevent leaks.

Immediate action is required upon contact with 2-fluoro-6-(trifluoromethyl)pyridine. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move person to fresh air and seek medical attention if breathing difficulties occur. For ingestion, do not induce vomiting and seek immediate medical attention.

2-fluoro-6-(trifluoromethyl)pyridine disposal must comply with local and national hazardous waste regulations. The compound cannot be disposed of through regular waste streams due to its hazardous classification. Contact licensed hazardous waste disposal companies for proper collection and treatment. Incineration at high temperatures in specialized facilities is typically required. Empty containers must also be treated as hazardous waste. Maintain detailed records of all disposal activities for regulatory compliance.

2-fluoro-6-(trifluoromethyl)pyridine is classified under ADR Class 3, Packing Group III as a flammable liquid. Transportation requires UN-approved packaging suitable for flammable liquids and proper hazard labeling with GHS02 and GHS07 pictograms. Vehicles must carry appropriate safety equipment and emergency response information. Drivers need ADR certification for dangerous goods transport. Ensure compliance with quantity limitations and route restrictions as specified in dangerous goods regulations.

2-fluoro-6-(trifluoromethyl)pyridine is subject to standard chemical regulations including REACH registration requirements in the European Union. The compound is not classified as a Substance of Very High Concern (SVHC) but must comply with CLP classification and labeling regulations showing Warning signal word and appropriate pictograms. Workplace exposure limits and safety data sheet requirements apply. Users must ensure regulatory compliance for import, use, and distribution within their respective jurisdictions.

2-fluoro-6-(trifluoromethyl)pyridine is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides reliable supply chains for pharmaceutical and chemical intermediates across Europe, ensuring product quality and regulatory compliance. As an established chemical distributor, OYSI offers technical support and handles all necessary documentation for safe transport and use. Contact OYSI directly for availability, specifications, and pricing information for your specific application requirements.