2-fluoro-6-(trifluoromethyl)pyridine

2-fluoro-6-(trifluoromethyl)pyridine is a fluorinated pyridine derivative with molecular formula C6H3F4N and CAS number 94239-04-0. This organic compound contains both a fluorine atom at position 2 and a trifluoromethyl group at position 6 of the pyridine ring. With a molecular weight of 165.09 g/mol, it belongs to the class of perfluorinated aromatic compounds used primarily as chemical intermediates in pharmaceutical and agrochemical synthesis.

2-fluoro-6-(trifluoromethyl)pyridine is typically a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. The presence of multiple fluorine atoms significantly affects its physical properties, including increased chemical stability and altered polarity compared to unsubstituted pyridine. The compound exhibits limited water solubility due to its fluorinated structure but shows good solubility in organic solvents such as alcohols, ethers, and hydrocarbons.

2-fluoro-6-(trifluoromethyl)pyridine serves primarily as a key building block in pharmaceutical and agrochemical synthesis. The compound is extensively used in the production of fluorinated drug intermediates, particularly in developing compounds with enhanced metabolic stability and bioavailability. Additionally, it finds applications in the synthesis of specialty chemicals, advanced materials, and as a precursor in the manufacture of crop protection agents where fluorine incorporation improves biological activity and environmental stability.

2-fluoro-6-(trifluoromethyl)pyridine requires careful handling due to its flammable and potentially toxic properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and appropriate respiratory protection in poorly ventilated areas. Work should be conducted in well-ventilated areas or under fume hoods, away from ignition sources. Given its Acute Tox. 4 classification, avoid skin contact and inhalation. Use proper grounding procedures when transferring the liquid to prevent static electricity buildup.

2-fluoro-6-(trifluoromethyl)pyridine should be stored in a cool, dry, well-ventilated area away from heat sources and ignition points due to its flammable liquid classification. Use tightly sealed, chemically compatible containers, preferably made of fluoropolymer or glass. Storage temperature should remain below 25°C to maintain stability. Keep away from strong oxidizing agents and bases. Ensure proper secondary containment and maintain appropriate fire suppression systems in storage areas according to Class 3 flammable liquid requirements.

Immediate action is required upon contact with 2-fluoro-6-(trifluoromethyl)pyridine due to its acute toxicity classification. For skin contact, immediately remove contaminated clothing and rinse affected areas with copious amounts of water for at least 15 minutes. In case of eye contact, flush thoroughly with water and seek immediate medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention promptly. Always consult the safety data sheet for complete emergency procedures.

2-fluoro-6-(trifluoromethyl)pyridine must be disposed of as hazardous waste according to local and European regulations. The compound cannot be discharged to sewers or waterways due to its aquatic chronic toxicity classification. Disposal should be performed through licensed waste management companies capable of handling flammable and toxic organic compounds. Consider incineration at high temperatures in specialized facilities equipped with appropriate emission control systems. Always consult local environmental authorities for specific disposal requirements and documentation.

2-fluoro-6-(trifluoromethyl)pyridine is classified as ADR Class 3, Packing Group III for transportation, indicating it is a flammable liquid with relatively low danger level. Transport requires appropriate UN-specification packaging designed for flammable liquids. Vehicles must carry proper documentation, emergency response information, and comply with ADR routing restrictions. Drivers need ADR certification for dangerous goods transport. Packages must display appropriate hazard labels including flammable liquid pictograms and proper shipping names as specified in ADR regulations.

2-fluoro-6-(trifluoromethyl)pyridine is subject to standard REACH and CLP regulations within the European Union but is not classified as a Substance of Very High Concern (SVHC). Registration requirements apply for manufacturers and importers above tonnage thresholds. The compound must be classified and labeled according to CLP regulation with appropriate warning pictograms (GHS02, GHS07) and hazard statements. Users must comply with occupational exposure limits and safety requirements for handling flammable and toxic substances in workplace environments.

2-fluoro-6-(trifluoromethyl)pyridine is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. OYSI provides reliable supply chains for research institutions, pharmaceutical companies, and chemical manufacturers across Europe. The compound is typically available in various packaging sizes to meet different application requirements. For pricing, availability, and technical specifications, contact OYSI directly. Ensure your supplier provides complete documentation including certificates of analysis and safety data sheets for regulatory compliance.