1H-indol-6-ol

1H-indol-6-ol is an organic chemical compound with the molecular formula C8H7NO and CAS number 2380-86-1. This indole derivative has a molecular weight of 133.15 g/mol and features a hydroxyl group (-OH) attached to the 6-position of the indole ring structure. It belongs to the indole family of heterocyclic aromatic compounds and is classified as hazardous under GHS regulations with acute toxicity, eye damage, skin sensitization, and aquatic toxicity properties.

1H-indol-6-ol is a solid organic compound at room temperature with a molecular weight of 133.15 g/mol. As an indole derivative containing both aromatic and hydroxyl functional groups, it typically exhibits moderate polarity. The compound's solubility characteristics are influenced by its phenolic hydroxyl group, which can form hydrogen bonds with polar solvents. Its indole structure contributes to its aromatic properties and potential for π-π interactions with other aromatic compounds.

1H-indol-6-ol serves as an important intermediate in pharmaceutical and chemical synthesis applications. This compound is primarily utilized in the development of pharmaceutical compounds, particularly in the synthesis of indole-based drugs and bioactive molecules. It also finds applications in research and development activities within the pharmaceutical industry, organic synthesis laboratories, and specialty chemical manufacturing. Its indole structure makes it valuable for creating complex molecular frameworks in medicinal chemistry.

1H-indol-6-ol requires careful handling due to its classification as Acute Tox. 4, Eye Dam. 1, and Skin Sens. 1. Essential personal protective equipment includes chemical-resistant gloves, safety goggles or face shield, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under fume hoods to minimize inhalation exposure. Avoid contact with eyes and skin, and ensure proper hygiene practices including thorough handwashing after handling.

1H-indol-6-ol should be stored in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers tightly closed when not in use to prevent moisture absorption and contamination. Store separately from incompatible materials such as strong oxidizing agents and bases. Ensure storage areas are equipped with appropriate spill containment measures and maintain temperatures within recommended ranges to preserve product stability and prevent degradation.

Immediate action is required in case of contact with 1H-indol-6-ol due to its eye damage and skin sensitization properties. For eye contact, rinse immediately with plenty of clean water for at least 15 minutes and seek medical attention immediately. In case of skin contact, wash thoroughly with soap and water, remove contaminated clothing. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention. Always consult safety data sheets for complete first aid procedures.

1H-indol-6-ol waste must be disposed of according to local and national hazardous waste regulations due to its toxicity and environmental hazard classification. Do not dispose of in regular waste streams or pour down drains. Contact licensed waste disposal companies specializing in chemical waste management. Waste should be properly labeled, contained in appropriate packaging, and documented according to waste tracking requirements. Consider waste minimization strategies and potential recycling or recovery options where feasible.

1H-indol-6-ol is classified under ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. This classification requires specific packaging, labeling, and documentation according to dangerous goods regulations. Packages must bear appropriate hazard labels and markings. Transportation should be conducted by trained personnel familiar with dangerous goods handling procedures. Ensure proper documentation including transport documents and emergency response information accompanies shipments.

1H-indol-6-ol is subject to REACH regulation requirements in Europe and must comply with CLP classification and labeling standards. The compound is not currently listed as a Substance of Very High Concern (SVHC) under REACH. Suppliers must provide Safety Data Sheets and ensure proper hazard classification and labeling according to GHS standards. Users must implement appropriate risk management measures and may need to register uses depending on quantities handled and supply chain position.

1H-indol-6-ol is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers. OYSI provides reliable supply chain solutions with proper regulatory compliance including REACH registration support and comprehensive safety documentation. As a professional chemical distributor, OYSI ensures product quality, proper packaging, and regulatory compliance for European markets. Contact OYSI directly for availability, specifications, and technical support for your specific application requirements.