2-fluoro-4-hydroxybenzonitrile

2-fluoro-4-hydroxybenzonitrile is an aromatic organic compound with the molecular formula C7H4FNO and CAS number 82380-18-5. This benzonitrile derivative features a fluorine atom at position 2 and a hydroxyl group at position 4 on the benzene ring, along with a cyano group. With a molecular weight of 137.11 g/mol, it serves as an important chemical intermediate in organic synthesis and pharmaceutical applications.

2-fluoro-4-hydroxybenzonitrile typically appears as a solid crystalline powder at room temperature. The compound contains both polar functional groups (hydroxyl and cyano) and a fluorine substituent, which influences its solubility characteristics. The presence of the hydroxyl group enables hydrogen bonding, while the fluorine atom affects the compound's electronic properties and reactivity patterns in chemical transformations.

2-fluoro-4-hydroxybenzonitrile serves primarily as a chemical intermediate in pharmaceutical synthesis and fine chemical manufacturing. The compound is utilized in the production of various active pharmaceutical ingredients (APIs) and specialty chemicals. Its unique substitution pattern makes it valuable for creating fluorinated aromatic compounds, which are increasingly important in modern drug discovery and agrochemical development due to their enhanced biological activity and metabolic stability.

2-fluoro-4-hydroxybenzonitrile requires careful handling due to its Acute Tox. 4 and Eye Dam. 1 classifications. Essential personal protective equipment includes chemical-resistant gloves, safety goggles or face shield, and appropriate respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin and eye contact, inhalation of dust or vapors, and ensure proper training on emergency procedures before handling.

2-fluoro-4-hydroxybenzonitrile should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers upright and properly labeled with hazard information. Storage areas should be equipped with appropriate spill containment measures and emergency equipment. Regular inspection of containers for damage or deterioration is recommended to maintain product integrity and safety.

Immediate action is required for contact with 2-fluoro-4-hydroxybenzonitrile due to its eye damage potential. For eye contact, rinse immediately with plenty of water for at least 15 minutes and seek medical attention immediately. For skin contact, wash thoroughly with soap and water. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek medical attention. Always consult the safety data sheet for complete emergency procedures.

2-fluoro-4-hydroxybenzonitrile disposal must comply with local, national, and international environmental regulations due to its Aquatic Chronic 2 classification. The compound should never be discharged into drains, soil, or water bodies. Disposal should be conducted through licensed hazardous waste disposal companies using appropriate methods such as controlled incineration. Contaminated packaging and materials require similar professional disposal treatment to prevent environmental impact.

2-fluoro-4-hydroxybenzonitrile is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation according to dangerous goods regulations. Transportation must comply with ADR/RID regulations for road/rail transport and IATA/IMDG for air/sea transport. Proper shipping names, hazard labels, and handling instructions must accompany all shipments.

2-fluoro-4-hydroxybenzonitrile falls under European REACH regulation requiring registration for manufacture or import above certain tonnages. The compound is classified under CLP regulation with specific hazard classifications (Acute Tox. 4, Eye Dam. 1, Aquatic Chronic 2) requiring appropriate labeling and safety data sheets. It is not currently listed as a SVHC (Substance of Very High Concern), but users must comply with all applicable chemical safety regulations and occupational exposure limits.

2-fluoro-4-hydroxybenzonitrile is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides high-quality chemical products with complete documentation including certificates of analysis, safety data sheets, and regulatory compliance information. Their European distribution network ensures reliable supply and technical support for industrial and research applications requiring this specialized benzonitrile derivative.