2-fluoro-4-hydroxybenzonitrile

2-fluoro-4-hydroxybenzonitrile is an aromatic organic compound with the molecular formula C7H4FNO and CAS number 82380-18-5. This chemical features a benzene ring substituted with a fluorine atom at position 2, a hydroxyl group at position 4, and a nitrile group. With a molecular weight of 137.11 g/mol, it belongs to the class of fluorinated benzonitriles and is classified as hazardous with acute toxicity and eye damage properties.

2-fluoro-4-hydroxybenzonitrile is a solid aromatic compound at room temperature with the molecular formula C7H4FNO. The presence of both fluorine and hydroxyl substituents on the benzene ring influences its polarity and solubility characteristics. The nitrile functional group contributes to its chemical reactivity. As a substituted benzonitrile, it exhibits typical aromatic properties while the specific substituent pattern affects its physical properties such as melting point and solubility in various solvents.

2-fluoro-4-hydroxybenzonitrile serves as an important intermediate in pharmaceutical and fine chemical synthesis. The compound's unique substitution pattern makes it valuable for developing active pharmaceutical ingredients and specialty chemicals. Its fluorine atom and hydroxyl group provide specific reactivity patterns useful in medicinal chemistry applications. The nitrile functionality allows for further chemical transformations, making it a versatile building block in organic synthesis and pharmaceutical research and development.

2-fluoro-4-hydroxybenzonitrile must be handled with extreme caution due to its Acute Tox. 4 and Eye Dam. 1 classifications. Mandatory personal protective equipment includes chemical-resistant gloves, safety goggles with side shields, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods. Avoid direct contact with skin, eyes, and inhalation of dust or vapors. Emergency eyewash stations and safety showers should be readily accessible when working with this substance.

2-fluoro-4-hydroxybenzonitrile should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. The storage area must be equipped with appropriate containment systems and restricted to authorized personnel only. Keep containers upright and properly labeled according to GHS requirements. Store separately from incompatible materials and ensure compliance with local chemical storage regulations. Regular inspection of containers for damage or leakage is recommended.

Immediate action is required if contact with 2-fluoro-4-hydroxybenzonitrile occurs due to its Eye Dam. 1 classification. For eye contact, rinse immediately with plenty of water for at least 15 minutes and seek immediate medical attention. In case of skin contact, wash thoroughly with soap and water. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet and contact poison control or emergency services when necessary.

2-fluoro-4-hydroxybenzonitrile must be disposed of according to local, national, and international hazardous waste regulations due to its toxic and environmentally hazardous properties. The substance cannot be disposed of in regular waste streams and requires specialized hazardous waste treatment. Contact licensed waste disposal companies for proper collection and treatment. Contaminated packaging materials also require hazardous waste disposal. Ensure proper documentation and tracking of waste disposal activities as required by applicable regulations.

2-fluoro-4-hydroxybenzonitrile is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. This classification requires specific packaging, labeling, and documentation according to international dangerous goods regulations. Packages must be properly marked and labeled with appropriate hazard symbols and shipping names. Transportation should be handled by certified dangerous goods carriers with appropriate training and equipment. Ensure compliance with all applicable national and international transport regulations.

2-fluoro-4-hydroxybenzonitrile is subject to standard EU chemical regulations including REACH and CLP requirements but is not currently listed as a Substance of Very High Concern (SVHC). The substance must comply with classification, labeling, and packaging regulations under CLP due to its hazardous properties. Users must ensure proper risk assessments, safety data sheet provisions, and worker protection measures. Additional sector-specific regulations may apply depending on the intended use and application of the substance.

2-fluoro-4-hydroxybenzonitrile is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound to qualified industrial and research customers across Europe with appropriate documentation and safety data sheets. As a specialized chemical requiring careful handling due to its hazardous properties, purchase is typically restricted to professional users with appropriate safety facilities and expertise. Contact OYSI directly for availability, specifications, and ordering information for your specific application requirements.