1,3-dioxolane

C3H6O2

CAS646-06-0
GHS02 Gefahrensymbol: Entzündbar – Flamme
Danger

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Identification

CAS Number
646-06-0
EC Number
211-463-5
UN Number
1166
Index Number
605-017-00-2
PubChem CID
12586

Physical-chemical properties

Molecular Formula
C3H6O2
Molar Mass
74.08 g/mol
IUPAC Name
1,3-dioxolane

Chemical Identifiers

InChI
InChI=1S/C3H6O2/c1-2-5-3-4-1/h1-3H2
InChI Key
WNXJIVFYUVYPPR-UHFFFAOYSA-N

Overview

1,3-Dioxolane (CAS 646-06-0) is a heterocyclic organic compound with excellent solvent properties and high chemical reactivity. This five-membered ring ether belongs to the dioxolane family and serves as a versatile chemical intermediate in numerous industrial applications. With its molecular formula C3H6O2 and relatively low molecular weight of 74.08 g/mol, 1,3-dioxolane exhibits unique physicochemical properties that make it valuable for specialized chemical processes. The compound's cyclic structure, containing two oxygen atoms in a 1,3-position, provides distinctive reactivity patterns compared to linear ethers and other cyclic compounds. As a flammable liquid classified under GHS02 pictogram with "Danger" signal word, 1,3-dioxolane requires careful handling and appropriate safety measures during storage and use. Its Flam. Liq. 2 classification and ADR Class 3 designation indicate significant fire hazards that necessitate proper ventilation, ignition source control, and compliance with relevant safety protocols. The compound's volatility and chemical reactivity demand specialized storage conditions and trained personnel for safe handling. In industrial applications, 1,3-dioxolane functions primarily as a protecting group reagent in organic synthesis, particularly for carbonyl compounds in pharmaceutical and fine chemical manufacturing. It also serves as a specialized solvent for polymer chemistry applications and as an intermediate in the production of various chemical compounds. While sharing some solvent characteristics with compounds like ethyl propanoate, 1,3-dioxolane offers unique selectivity and reactivity profiles that make it indispensable for specific synthetic routes. OYSI provides high-quality 1,3-dioxolane to meet the demanding requirements of European chemical industries, ensuring consistent supply and technical support for specialized applications.

Safety & Classification

Danger
Classification:

Flam. Liq. 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Transport (ADR)

UN Number1166
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameDioxolan
Marine PollutantNo

Frequently Asked Questions

What is 1,3-dioxolane?

1,3-dioxolane is a heterocyclic organic compound with the chemical formula C3H6O2 and CAS number 646-06-0. It belongs to the dioxolane family, featuring a five-membered ring containing two oxygen atoms. With a molecular weight of 74.08 g/mol, this compound is classified as a flammable liquid and requires careful handling due to its fire hazard properties.

What are the physicochemical properties of 1,3-dioxolane?

1,3-dioxolane is a colorless liquid at room temperature with a characteristic ether-like odor. It exhibits excellent solubility in water and most organic solvents due to its polar nature. The compound has a relatively low boiling point and high volatility, making it easily evaporable. Its chemical structure provides both hydrophilic and lipophilic characteristics, contributing to its versatility as a solvent.

What is 1,3-dioxolane used for?

1,3-dioxolane is primarily used as a polar aprotic solvent in various chemical reactions and industrial processes. It serves as an excellent medium for organometallic reactions, polymer synthesis, and electrochemical applications. The compound is also utilized in the production of specialty chemicals, as a reaction medium for lithium battery electrolytes, and in pharmaceutical intermediate synthesis where its unique solvating properties are advantageous.

How to handle 1,3-dioxolane safely?

1,3-dioxolane must be handled with appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and flame-resistant clothing. Work in well-ventilated areas away from ignition sources, as it is classified as Flam. Liq. 2 with GHS02 pictogram. Avoid static electricity buildup and use grounded equipment. Never smoke or use open flames nearby, and ensure emergency eyewash and shower facilities are accessible.

How to store 1,3-dioxolane correctly?

1,3-dioxolane should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition points. Keep containers grounded and use explosion-proof electrical equipment in storage areas. Store separately from strong oxidizing agents and incompatible materials. Maintain storage temperature below 25°C and ensure adequate fire suppression systems are in place due to its flammable nature.

What to do in case of contact with 1,3-dioxolane?

In case of skin contact with 1,3-dioxolane, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention. Always consult a physician if symptoms persist.

How to dispose of 1,3-dioxolane properly?

1,3-dioxolane must be disposed of according to local and national environmental regulations as hazardous waste. Never pour down drains or dispose of in regular waste. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities can often be incinerated in approved facilities with appropriate emission controls. Always consult local authorities for specific disposal requirements and documentation needs.

How to transport 1,3-dioxolane?

1,3-dioxolane is classified under ADR Class 3 (flammable liquids), Packing Group II, requiring specialized transport procedures. It must be shipped in UN-approved packaging with proper labeling including the GHS02 flame pictogram and 'Danger' signal word. Transport vehicles must comply with ADR regulations for flammable liquids, including appropriate placarding, driver training, and emergency response equipment.

Is 1,3-dioxolane subject to specific regulations?

1,3-dioxolane is subject to CLP regulation with classification as Flam. Liq. 2 and must display appropriate GHS hazard communication elements. It falls under REACH regulation requiring registration for manufacture or import above one tonne per year. The substance is not currently listed as SVHC (Substance of Very High Concern), but users must comply with workplace safety regulations and transport requirements under ADR.

Where to buy 1,3-dioxolane in Europe?

1,3-dioxolane is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this compound to industrial customers across Europe with appropriate documentation, safety data sheets, and regulatory compliance support. The company ensures proper packaging, labeling according to CLP requirements, and reliable supply chain management for customers requiring this specialized solvent for their chemical processes and applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.