1,3-dioxolane
C3H6O2
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Identification
- CAS Number
- 646-06-0
- EC Number
- 211-463-5
- UN Number
- 1166
- Index Number
- 605-017-00-2
- PubChem CID
- 12586
Physical-chemical properties
- Molecular Formula
- C3H6O2
- Molar Mass
- 74.08 g/mol
- IUPAC Name
- 1,3-dioxolane
Chemical Identifiers
- InChI
- InChI=1S/C3H6O2/c1-2-5-3-4-1/h1-3H2
- InChI Key
- WNXJIVFYUVYPPR-UHFFFAOYSA-N
Overview
1,3-Dioxolane (CAS 646-06-0) is a cyclic ether solvent with high volatility and excellent dissolving properties for organic compounds. This five-membered heterocyclic compound consists of a ring structure containing two oxygen atoms and three carbon atoms, making it a valuable solvent in various industrial applications. With its molecular formula C3H6O2 and molecular weight of 74.08 g/mol, 1,3-dioxolane exhibits characteristics typical of cyclic ethers while offering unique solvent properties that distinguish it from linear alternatives. The compound presents as a colorless liquid with relatively high vapor pressure, contributing to its effectiveness as a process solvent. Its chemical structure provides good stability under normal conditions while maintaining reactivity suitable for specific synthetic applications. Like other ether solvents such as ethyl propanoate, 1,3-dioxolane demonstrates excellent solvating power for a wide range of organic materials, though its cyclic nature provides distinct advantages in certain formulations. Safety considerations are paramount when handling 1,3-dioxolane, as it is classified as Flam. Liq. 2 under GHS regulations, requiring appropriate fire prevention measures and proper ventilation systems. The compound falls under ADR Class 3 for transportation, necessitating compliance with hazardous material shipping protocols. Primary industrial applications include its use as a reaction solvent in pharmaceutical synthesis, as a component in specialized coating formulations, and as an intermediate in polymer production processes. Its unique combination of solvating power and controlled volatility makes it particularly valuable in applications requiring precise evaporation rates. OYSI maintains reliable supply chains for 1,3-dioxolane, ensuring consistent availability for European industrial customers requiring this specialized cyclic ether solvent.
Safety & Classification
Flam. Liq. 2
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Highly flammable liquid and vapour.
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Transport (ADR)
| UN Number | 1166 |
| ADR Class | 3 |
| Packing Group | II |
| Tunnel Code | D/E |
| Proper Shipping Name | Dioxolan |
| Marine Pollutant | No |
Frequently Asked Questions
What is 1,3-dioxolane?
1,3-dioxolane is a cyclic ether compound with the molecular formula C3H6O2 and CAS number 646-06-0. This heterocyclic organic solvent features a five-membered ring containing two oxygen atoms at positions 1 and 3. With a molecular weight of 74.08 g/mol, it is classified as a flammable liquid category 2, making it an important industrial solvent requiring careful handling due to its fire hazard properties.
What are the physicochemical properties of 1,3-dioxolane?
1,3-dioxolane is a colorless, volatile liquid at room temperature with a characteristic ether-like odor. It has excellent solvent properties and can dissolve both polar and nonpolar compounds. The compound exhibits good miscibility with many organic solvents and has moderate water solubility. Its cyclic structure provides stability while maintaining useful reactivity, making it valuable in various chemical processes and formulations.
What is 1,3-dioxolane used for?
1,3-dioxolane serves primarily as a high-performance solvent in chemical synthesis and industrial processes. It is commonly used as a reaction medium for organometallic chemistry, polymer synthesis, and pharmaceutical manufacturing. The compound also functions as a protecting group for carbonyl compounds in organic synthesis. Additionally, it finds applications in coating formulations, adhesives, and as a component in specialty chemical products requiring aprotic solvents.
How to handle 1,3-dioxolane safely?
1,3-dioxolane requires careful handling due to its flammable liquid category 2 classification. Always wear appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and flame-resistant clothing. Work in well-ventilated areas away from ignition sources, sparks, and open flames. Use explosion-proof electrical equipment and ensure proper grounding of containers. Avoid inhalation of vapors and prevent skin contact. Keep fire extinguishing equipment readily available during use.
How to store 1,3-dioxolane correctly?
1,3-dioxolane must be stored in a cool, dry, well-ventilated area away from heat sources and ignition points. Use only approved containers and keep them tightly sealed to prevent vapor escape. Store separately from strong oxidizing agents and acids to avoid incompatible reactions. Maintain storage temperatures below 25°C and ensure adequate fire suppression systems are in place. Check containers regularly for leaks and ensure proper labeling with hazard warnings.
What to do in case of contact with 1,3-dioxolane?
In case of skin contact with 1,3-dioxolane, immediately remove contaminated clothing and rinse the affected area with plenty of water for at least 15 minutes. For eye contact, flush thoroughly with water and seek immediate medical attention. If inhaled, move the person to fresh air and provide oxygen if breathing is difficult. In case of ingestion, do not induce vomiting and seek medical help immediately. Always consult a physician after any significant exposure.
How to dispose of 1,3-dioxolane properly?
1,3-dioxolane disposal must comply with local, national, and European waste regulations as a hazardous chemical waste. The substance cannot be disposed of in regular drains or municipal waste systems. Contact licensed hazardous waste disposal companies for proper treatment, which may include incineration at authorized facilities or chemical treatment. Maintain detailed records of waste quantities and disposal methods. Empty containers should also be treated as hazardous waste due to residual vapors.
How to transport 1,3-dioxolane?
1,3-dioxolane is classified under ADR as Class 3 (flammable liquids), Packing Group II, requiring specific transport regulations. Use UN-approved packaging and ensure proper hazard labeling with GHS02 pictograms and 'Danger' signal words. Vehicles must comply with ADR requirements including appropriate fire extinguishers and safety equipment. Drivers need ADR certification for dangerous goods transport. Avoid transport during extreme temperatures and ensure emergency response information accompanies shipments.
Is 1,3-dioxolane subject to specific regulations?
1,3-dioxolane is subject to various European regulations including REACH registration requirements and CLP classification as Flam. Liq. 2. The substance is not currently listed as an SVHC (Substance of Very High Concern) under REACH. Companies must comply with workplace exposure limits, safety data sheet requirements, and proper labeling with GHS02 pictograms. Additional national regulations may apply depending on the country of use, particularly regarding storage, handling, and workplace safety measures.
Where to buy 1,3-dioxolane in Europe?
1,3-dioxolane is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides high-quality 1,3-dioxolane with complete regulatory documentation including safety data sheets and certificates of analysis. As an established chemical distributor, OYSI ensures compliance with European regulations and provides technical support for proper handling and application. Contact OYSI directly for pricing, availability, and delivery options throughout Europe for your specific quantity requirements.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.