1,2-dibromo-3-chloropropane

C3H5Br2Cl

CAS96-12-8
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
Danger

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Identification

CAS Number
96-12-8
EC Number
202-479-3
UN Number
2872
Index Number
602-021-00-6
PubChem CID
7280

Physical-chemical properties

Molecular Formula
C3H5Br2Cl
Molar Mass
236.33 g/mol
IUPAC Name
1,2-dibromo-3-chloropropane

Chemical Identifiers

InChI
InChI=1S/C3H5Br2Cl/c4-1-3(5)2-6/h3H,1-2H2
InChI Key
WBEJYOJJBDISQU-UHFFFAOYSA-N

Overview

1,2-Dibromo-3-chloropropane (CAS 96-12-8) is a halogenated organic compound with significant industrial applications and notable toxicological properties. This trihalogenated propane derivative, with the molecular formula C3H5Br2Cl and a molecular weight of 236.33 g/mol, represents an important class of organohalogen compounds used in specialized chemical processes. The compound contains both bromine and chlorine substituents on a three-carbon chain, resulting in unique reactivity patterns that make it valuable for specific industrial applications. From a safety perspective, 1,2-dibromo-3-chloropropane requires careful handling due to its classification as a Category 1B carcinogen and mutagen, as well as a Category 1A reproductive toxicant. The substance displays GHS08 and GHS06 pictograms with a "Danger" signal word, reflecting its serious health hazards including acute toxicity and specific target organ toxicity following repeated exposure. Its ADR classification as Class 6.1 indicates toxic substances transport requirements. Like other halogenated compounds such as chloromethylbenzene, proper ventilation and protective equipment are essential during handling and processing. Industrial applications of this compound include use as an intermediate in pharmaceutical synthesis, as a chemical building block for specialty polymers, and in certain pesticide formulations where its halogenated structure provides desired biological activity. The compound's reactivity profile makes it particularly useful in nucleophilic substitution reactions and cross-coupling processes. The substance also presents environmental considerations due to its Aquatic Chronic 3 classification, requiring appropriate waste management and disposal protocols to prevent ecological impact. OYSI maintains availability of 1,2-dibromo-3-chloropropane for qualified industrial customers across Europe, ensuring compliance with all relevant chemical safety and transport regulations.

Safety & Classification

Danger
Classification:

Carc. 1B; Muta. 1B; Repr. 1A; Acute Tox. 3 *; STOT RE 2 *; Aquatic Chronic 3

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H340

May cause genetic defects.

H301

Toxic if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H412

Harmful to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2872
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Name1,2-Dibrom-3-chlorpropan
Marine PollutantNo

Frequently Asked Questions

What is 1,2-dibromo-3-chloropropane?

1,2-dibromo-3-chloropropane is an organohalocarbon compound with the molecular formula C3H5Br2Cl and CAS number 96-12-8. This synthetic chemical substance has a molecular weight of 236.33 g/mol and contains both bromine and chlorine atoms attached to a three-carbon propane backbone. It is classified as extremely hazardous due to its carcinogenic, mutagenic, and reproductive toxic properties, requiring strict handling protocols and safety measures in professional environments.

What are the physicochemical properties of 1,2-dibromo-3-chloropropane?

1,2-dibromo-3-chloropropane is typically a colorless to pale yellow liquid at room temperature with a characteristic sweet odor. The compound has limited water solubility but is miscible with most organic solvents including alcohols, ethers, and chlorinated hydrocarbons. Its high density and volatility require careful consideration during handling and storage operations to prevent exposure and environmental contamination.

What is 1,2-dibromo-3-chloropropane used for?

1,2-dibromo-3-chloropropane was historically used as a soil fumigant and nematicide in agricultural applications, particularly for controlling parasitic nematodes in crops. However, due to its severe health hazards including carcinogenicity and reproductive toxicity, its use has been heavily restricted or banned in most countries. Currently, it may only be used in very limited research applications under strict regulatory oversight and safety protocols.

How to handle 1,2-dibromo-3-chloropropane safely?

1,2-dibromo-3-chloropropane requires maximum personal protection including full-face respirators with organic vapor cartridges, chemically resistant gloves (nitrile or neoprene), and complete body coverage with chemical-resistant clothing. Work must be conducted in well-ventilated areas or fume hoods to prevent inhalation exposure. Due to its carcinogenic and reproductive toxic properties, only trained personnel should handle this substance following strict safety protocols and exposure monitoring procedures.

How to store 1,2-dibromo-3-chloropropane correctly?

1,2-dibromo-3-chloropropane must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources, ignition sources, and incompatible materials. Storage areas should be equipped with appropriate spill containment systems and restricted access controls. The substance should be kept away from strong bases, metals, and oxidizing agents which may cause dangerous reactions or accelerated decomposition.

What to do in case of contact with 1,2-dibromo-3-chloropropane?

Immediate action is critical following 1,2-dibromo-3-chloropropane exposure. For skin contact, remove contaminated clothing and wash affected areas thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes. If inhaled, move the person to fresh air immediately. Seek immediate medical attention for any exposure route and inform medical personnel about the specific chemical involved and its hazardous properties.

How to dispose of 1,2-dibromo-3-chloropropane appropriately?

1,2-dibromo-3-chloropropane disposal must comply with strict hazardous waste regulations due to its carcinogenic and toxic properties. The substance cannot be disposed of through normal waste streams and requires specialized hazardous waste treatment facilities licensed for organohalogen compounds. Contact certified waste management companies for proper collection and destruction, typically through high-temperature incineration with appropriate emission controls to prevent environmental contamination.

How to transport 1,2-dibromo-3-chloropropane?

1,2-dibromo-3-chloropropane is classified under ADR as Class 6.1 (toxic substances), Packing Group III for transportation purposes. Packages must bear appropriate hazard labels including toxic substance markings and proper shipping names. Transport vehicles require placarding and drivers need hazardous materials certification. The substance must be packaged in UN-specification containers with adequate cushioning and leak protection to prevent release during transport.

Is 1,2-dibromo-3-chloropropane subject to specific regulations?

1,2-dibromo-3-chloropropane is subject to extensive regulatory controls under REACH, CLP, and national chemical safety legislation across Europe. Its classification as Carcinogenic 1B, Mutagenic 1B, and Reproductive Toxicant 1A triggers strict authorization requirements and use restrictions. The substance faces significant regulatory scrutiny and potential phase-out measures due to its severe health and environmental concerns, requiring comprehensive risk assessments for any permitted uses.

Where to buy 1,2-dibromo-3-chloropropane in Europe?

1,2-dibromo-3-chloropropane availability is extremely limited due to its hazardous classification and regulatory restrictions across European markets. OYSI, as a specialized European chemical distributor, can provide information about availability and regulatory compliance requirements for qualified industrial customers with legitimate research applications. Any supply requires thorough documentation of intended use, safety protocols, and regulatory authorization due to the substance's severe health hazard classification.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.