1-methyl-3-nitro-1-nitrosoguanidine

1-methyl-3-nitro-1-nitrosoguanidine is a highly toxic chemical compound with the molecular formula C2H5N5O3 and CAS number 70-25-7. This synthetic substance has a molecular weight of 147.09 g/mol and is classified as a Category 1B carcinogen. It belongs to the guanidine family of compounds and contains both nitro and nitroso functional groups, making it extremely hazardous and requiring strict safety protocols for handling.

1-methyl-3-nitro-1-nitrosoguanidine is typically a crystalline solid at room temperature with a pale yellow to orange color. The compound is moderately soluble in water and polar organic solvents due to its polar functional groups. It has a molecular weight of 147.09 g/mol and contains multiple nitrogen-oxygen bonds that contribute to its instability and reactivity. The presence of both nitro and nitroso groups makes it sensitive to light and heat.

1-methyl-3-nitro-1-nitrosoguanidine is primarily used as a research chemical in laboratory settings for mutagenesis studies and DNA research. It serves as a potent alkylating agent in molecular biology applications, particularly for inducing specific mutations in bacterial and cell culture studies. Due to its extreme carcinogenicity and toxicity, its use is strictly limited to specialized research facilities with appropriate safety infrastructure and trained personnel.

1-methyl-3-nitro-1-nitrosoguanidine requires extreme caution during handling due to its carcinogenic properties. Essential PPE includes nitrile gloves (double-layered), full face protection, and lab coats. Work must be conducted in a well-ventilated fume hood or controlled atmosphere. Avoid skin contact, inhalation, and ingestion completely. Only trained personnel should handle this substance, and all work should follow strict laboratory protocols with emergency procedures readily available.

1-methyl-3-nitro-1-nitrosoguanidine must be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly sealed in their original packaging and store separately from incompatible materials such as strong acids, bases, and oxidizing agents. Storage areas should be clearly labeled with appropriate hazard warnings and access restricted to authorized personnel only. Regular inventory checks and proper labeling are essential.

Immediate action is critical upon contact with 1-methyl-3-nitro-1-nitrosoguanidine. For skin contact, remove contaminated clothing and rinse affected area with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting. Seek immediate medical attention in all cases and provide the safety data sheet to medical personnel.

1-methyl-3-nitro-1-nitrosoguanidine disposal requires specialized hazardous waste procedures due to its carcinogenic classification. Never dispose of this substance through regular waste streams or down drains. Contact licensed hazardous waste disposal companies for proper collection and treatment. All contaminated materials, including PPE and containers, must be treated as hazardous waste. Documentation of disposal methods and quantities is mandatory for regulatory compliance and traceability.

Transportation of 1-methyl-3-nitro-1-nitrosoguanidine requires compliance with dangerous goods regulations due to its toxic and carcinogenic properties. Proper packaging in UN-approved containers with appropriate labeling and documentation is essential. Transport should be handled by qualified carriers experienced with hazardous chemicals. Emergency response information must accompany shipments, and all transport documentation must clearly identify the substance and its hazards for emergency responders.

1-methyl-3-nitro-1-nitrosoguanidine is subject to strict regulatory controls under REACH and CLP regulations in Europe due to its Category 1B carcinogenic classification. It requires specialized handling permits and safety protocols in most jurisdictions. Research facilities using this compound must comply with occupational health regulations and may require special licensing. Import/export may be restricted, and detailed safety data sheets and exposure assessments are mandatory for legal use.

1-methyl-3-nitro-1-nitrosoguanidine is available through specialized chemical distributors like OYSI, which serves the European market with high-quality research chemicals. Due to its hazardous classification, purchases typically require institutional credentials, proper licensing, and compliance verification. OYSI provides comprehensive documentation, safety data sheets, and regulatory support for laboratory customers requiring this research compound while ensuring full compliance with European chemical regulations.