1-methyl-3-nitro-1-nitrosoguanidine

1-methyl-3-nitro-1-nitrosoguanidine is a synthetic chemical compound with the molecular formula C2H5N5O3 and CAS number 70-25-7. This substance has a molecular weight of 147.09 g/mol and belongs to the nitroso compounds family. It is classified as a Category 1B carcinogen, making it a substance of high concern for human health. The compound is primarily used in research applications and requires strict safety protocols due to its hazardous properties.

1-methyl-3-nitro-1-nitrosoguanidine is a solid compound at room temperature with a molecular weight of 147.09 g/mol. The substance typically appears as a crystalline powder and is sensitive to light and heat. It shows moderate solubility in polar solvents such as water and alcohols. The compound contains both nitro and nitroso functional groups, which contribute to its chemical reactivity and instability under certain conditions.

1-methyl-3-nitro-1-nitrosoguanidine is primarily used as a research chemical in laboratory settings, particularly in molecular biology and genetic research. It serves as a mutagen in scientific studies investigating DNA damage and repair mechanisms. The compound is also utilized in pharmaceutical research for understanding carcinogenesis processes. Due to its highly hazardous nature, its use is strictly limited to controlled laboratory environments with appropriate safety measures.

1-methyl-3-nitro-1-nitrosoguanidine must be handled with extreme caution due to its carcinogenic properties. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and laboratory coats. Work in a well-ventilated area or under a fume hood to prevent inhalation. Avoid skin and eye contact completely. Use only the minimum quantity required and ensure all personnel are trained in handling carcinogenic substances before use.

1-methyl-3-nitro-1-nitrosoguanidine should be stored in a cool, dry place away from direct sunlight and heat sources. Keep the container tightly closed in a designated area for carcinogenic substances with restricted access. Store separately from incompatible materials such as strong oxidizers and reducing agents. Maintain storage temperature below 25°C and ensure proper labeling with hazard warnings. Regular inventory checks should be conducted to monitor container integrity.

Immediate action is required in case of contact with 1-methyl-3-nitro-1-nitrosoguanidine. For skin contact, remove contaminated clothing and rinse the affected area with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with water for 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical care. Always contact emergency services and provide the safety data sheet.

1-methyl-3-nitro-1-nitrosoguanidine must be disposed of as hazardous waste through licensed waste management companies specializing in carcinogenic substances. Never dispose of this material in regular waste streams or pour down drains. Collect waste in appropriate containers labeled for carcinogenic materials. Contact certified hazardous waste disposal services and provide complete documentation including safety data sheets. Follow all local and European waste regulations for Category 1B carcinogens.

Transportation of 1-methyl-3-nitro-1-nitrosoguanidine must comply with ADR regulations for dangerous goods. The substance requires proper classification and packaging according to international transport standards. Use appropriate shipping containers that meet UN specifications and ensure proper hazard labeling including carcinogen warnings. Only qualified carriers experienced in handling hazardous chemicals should transport this material. Provide transport documents and emergency response information to carriers.

1-methyl-3-nitro-1-nitrosoguanidine is subject to strict regulatory controls under European legislation including REACH and CLP regulations. As a Category 1B carcinogen, it requires authorization for certain uses and is subject to workplace exposure limits. The substance must be registered under REACH if imported or manufactured above threshold quantities. Special labeling requirements apply with danger pictogrammes GHS07, GHS08, and GHS09, along with appropriate hazard statements and precautionary measures.

1-methyl-3-nitro-1-nitrosoguanidine is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this research chemical with full regulatory compliance and appropriate safety documentation. As a controlled substance due to its carcinogenic properties, purchase may require specific licensing or end-use declarations. Contact OYSI directly to discuss availability, regulatory requirements, and safety protocols for handling this hazardous material in your specific application.