Naphthalen-2-amine;hydrochloride

C10H10ClN

naphthalen-2-amine;hydrochloride

CAS612-52-2
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
612-52-2
EC Number
210-313-6
UN Number
Index Number
612-071-00-0
PubChem CID
12208544

Physical-chemical properties

Molecular Formula
C10H10ClN
Molar Mass
179.64 g/mol
IUPAC Name
naphthalen-2-amine;hydrochloride

Chemical Identifiers

InChI
InChI=1S/C10H9N.ClH/c11-10-6-5-8-3-1-2-4-9(8)7-10;/h1-7H,11H2;1H
InChI Key
QKGIPGSKJBOHSL-UHFFFAOYSA-N

Overview

Naphthalen-2-amine hydrochloride (CAS 612-52-2) is an aromatic amine salt compound with significant industrial applications and notable carcinogenic properties. This crystalline organic compound, also known by its EC number 210-313-6, represents the hydrochloride salt form of naphthalen-2-amine, featuring enhanced stability and solubility characteristics compared to its free base counterpart. With a molecular formula of C10H10ClN and molecular weight of 179.64 g/mol, this naphthalene derivative belongs to the class of aromatic amines that have found extensive use in chemical synthesis and manufacturing processes. The compound carries serious safety considerations, classified under GHS as Carcinogenic Category 1A, indicating known carcinogenic potential to humans. Additional hazard classifications include Acute Toxicity Category 4 and Aquatic Chronic Toxicity Category 2, necessitating strict handling protocols and appropriate safety measures. The associated GHS pictograms (GHS08, GHS07, GHS09) and "Danger" signal word reflect these significant health and environmental risks. Industrial applications primarily center around its role as an intermediate in dye manufacturing, pharmaceutical synthesis, and chemical research. The compound serves as a crucial building block in the production of various azo dyes and organic pigments, where its aromatic amine structure provides essential reactivity for coupling reactions. It also functions as a synthetic intermediate in pharmaceutical chemistry, particularly in the development of specialized therapeutic compounds. Like related aromatic amines such as naphthalen-2-amine, this hydrochloride salt requires specialized handling expertise and comprehensive safety protocols due to its carcinogenic classification. OYSI provides naphthalen-2-amine hydrochloride to qualified industrial customers with appropriate safety certifications and handling capabilities.

Safety & Classification

Danger
Classification:

Carc. 1A; Acute Tox. 4 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H302

Harmful if swallowed.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Frequently Asked Questions

What is naphthalen-2-amine;hydrochloride?

Naphthalen-2-amine;hydrochloride is an organic chemical compound with the molecular formula C10H10ClN and CAS number 612-52-2. This substance is the hydrochloride salt form of 2-naphthylamine, featuring a naphthalene ring structure with an amino group attached. With a molecular weight of 179.64 g/mol, it is classified as a Category 1A carcinogen under GHS regulations, making it a substance of high concern for human health and requiring strict handling protocols.

What are the physicochemical properties of naphthalen-2-amine;hydrochloride?

Naphthalen-2-amine;hydrochloride typically appears as a crystalline solid at room temperature, often presenting as white to pale yellow crystals or powder. As a hydrochloride salt, it exhibits good water solubility compared to its free base form. The compound has a molecular weight of 179.64 g/mol and contains both aromatic and ionic characteristics due to its naphthalene ring system and hydrochloride functionality, affecting its physical behavior and chemical reactivity.

What is naphthalen-2-amine;hydrochloride used for?

Naphthalen-2-amine;hydrochloride is primarily used as an intermediate in chemical synthesis and research applications. Due to its carcinogenic classification (Carc. 1A), its use is heavily restricted and mainly limited to controlled laboratory settings and specialized industrial processes under strict safety protocols. It may serve as a precursor for dye synthesis, pharmaceutical research, or analytical chemistry applications, but always requires authorization and compliance with severe regulatory restrictions.

How to handle naphthalen-2-amine;hydrochloride safely?

Naphthalen-2-amine;hydrochloride requires extreme caution during handling due to its Category 1A carcinogenic classification. Essential protective equipment includes nitrile gloves, safety goggles, lab coat, and respiratory protection. Work must be conducted in a well-ventilated area, preferably under a fume hood. Avoid skin contact, inhalation, and ingestion completely. Personnel must be trained in carcinogen handling procedures, and all activities should follow institutional safety protocols and regulatory guidelines for Category 1A carcinogens.

How to store naphthalen-2-amine;hydrochloride correctly?

Naphthalen-2-amine;hydrochloride must be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly closed and properly labeled with hazard warnings. Storage should be in a designated area for carcinogenic substances with restricted access and appropriate security measures. Avoid exposure to moisture, strong oxidizers, and bases. Regular inventory checks and proper documentation are essential, following institutional guidelines for Category 1A carcinogen storage requirements.

What to do in case of contact with naphthalen-2-amine;hydrochloride?

Immediate action is critical if contact occurs with naphthalen-2-amine;hydrochloride. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. If inhaled, move to fresh air immediately. For eye contact, flush with water for 15 minutes. In all cases, seek immediate medical attention and inform healthcare providers of the carcinogenic nature of the substance. Never induce vomiting if ingested - rinse mouth and seek emergency medical care.

How to dispose of naphthalen-2-amine;hydrochloride appropriately?

Naphthalen-2-amine;hydrochloride disposal requires specialized hazardous waste procedures due to its carcinogenic classification. Contact licensed hazardous waste disposal companies authorized to handle Category 1A carcinogens. Never dispose of in regular waste streams, sewers, or environment. Waste must be properly containerized, labeled, and documented with waste manifests. Follow local and national regulations for carcinogenic waste disposal, including potential incineration at high temperatures in authorized facilities under controlled conditions.

How to transport naphthalen-2-amine;hydrochloride?

Naphthalen-2-amine;hydrochloride transport requires compliance with hazardous goods regulations, though specific ADR classification data is not provided. Due to its carcinogenic nature and acute toxicity (Category 4), specialized packaging and documentation are necessary. Transport must be conducted by qualified carriers authorized for hazardous chemicals. Proper labeling with GHS pictograms (GHS07, GHS08, GHS09) and hazard information is mandatory. Consult current transport regulations and work with experienced logistics providers familiar with carcinogenic substance requirements.

Is naphthalen-2-amine;hydrochloride subject to particular regulations?

Naphthalen-2-amine;hydrochloride is subject to extensive regulatory oversight due to its Category 1A carcinogenic classification. Under REACH and CLP regulations, it requires strict authorization procedures and is likely subject to significant use restrictions. The substance falls under workplace safety regulations requiring special handling protocols, employee training, and health monitoring. Given its environmental classification (Aquatic Chronic 2), additional environmental protection measures apply. Always verify current regulatory status before use.

Where to buy naphthalen-2-amine;hydrochloride in Europe?

Naphthalen-2-amine;hydrochloride is available through OYSI, a European distributor of specialized chemical products. Due to its carcinogenic classification, purchase requires proper authorization, documentation of legitimate use, and compliance with regulatory requirements. Buyers must demonstrate appropriate safety protocols and legal authorization for handling Category 1A carcinogens. Contact OYSI directly for availability, regulatory documentation, and specific purchasing procedures required for this controlled substance in your jurisdiction.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.