1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride

C8H14ClN3O2S

CAS81880-96-8
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

Consulting for 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride

Our experts support you with application, dosage, and compliance.

Request Consultation

Identification

CAS Number
81880-96-8
EC Number
406-090-1
UN Number
2811
Index Number
007-025-00-6
PubChem CID
14234263

Physical-chemical properties

Molecular Formula
C8H14ClN3O2S
Molar Mass
251.73 g/mol
IUPAC Name
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride

Chemical Identifiers

InChI
InChI=1S/C8H13N3O2S.ClH/c1-10-14(12,13)6-7-2-4-8(11-9)5-3-7;/h2-5,10-11H,6,9H2,1H3;1H
InChI Key
WZZPGBAXFSIKJJ-UHFFFAOYSA-N

Overview

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide hydrochloride (CAS 81880-96-8) is an organic sulfonamide derivative featuring hydrazine and methylsulfonamide functional groups with significant biological activity potential. This specialized chemical compound represents a unique combination of sulfonamide and hydrazine chemistry, incorporating both N-methylmethanesulfonamide and hydrazinylphenyl structural elements. With a molecular formula of C8H14ClN3O2S and molecular weight of 251.73 g/mol, this hydrochloride salt demonstrates enhanced stability and solubility compared to its free base form. The compound belongs to the broader family of substituted hydrazines, sharing structural similarities with phenylhydrazine while offering distinct reactivity patterns due to its sulfonamide functionality. Safety considerations are paramount when handling this material, as it carries multiple hazard classifications including mutagenicity (Category 2), acute toxicity (Category 3), and specific target organ toxicity with repeated exposure (Category 1). The compound also presents skin sensitization risks and environmental concerns with aquatic toxicity classifications. These properties necessitate strict adherence to safety protocols, appropriate personal protective equipment, and controlled handling procedures in accordance with ADR Class 6.1 transportation requirements. Primary industrial applications include pharmaceutical intermediate synthesis, where the hydrazine functionality enables formation of heterocyclic compounds and drug scaffolds. The compound serves as a valuable building block in medicinal chemistry research, particularly for developing compounds with potential therapeutic properties. Additionally, it finds use in specialized organic synthesis applications where both sulfonamide and hydrazine reactivities are required. OYSI maintains reliable supply chains for this specialized intermediate, ensuring consistent availability for European chemical manufacturers and research institutions requiring high-quality materials for advanced synthetic applications.

Safety & Classification

Danger
Classification:

Muta. 2; Acute Tox. 3 *; STOT RE 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H341

Suspected of causing genetic defects.

H301

Toxic if swallowed.

H372

Causes damage to organs through prolonged or repeated exposure.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2811
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name(4-Hydrazinophenyl)-N-methylmethansulfonamid-hydrochlorid
Marine PollutantNo

Frequently Asked Questions

What is 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is an organic chemical compound with the molecular formula C8H14ClN3O2S and CAS number 81880-96-8. This specialized chemical has a molecular weight of 251.73 g/mol and belongs to the sulfonamide family. It is classified as a hazardous substance with multiple risk categories including mutagenic properties, acute toxicity, and environmental hazards, requiring careful handling and storage procedures.

What are the physicochemical properties of 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride has a molecular formula of C8H14ClN3O2S with a molecular weight of 251.73 g/mol. As a hydrochloride salt, it typically appears as a crystalline solid at room temperature. The compound contains both hydrazine and sulfonamide functional groups, which influence its chemical reactivity and solubility characteristics. Specific physical properties such as melting point, solubility, and appearance may vary depending on purity and manufacturing conditions.

What is 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride used for?

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is primarily used in pharmaceutical research and chemical synthesis applications. The compound's hydrazine and sulfonamide functional groups make it valuable as an intermediate in organic synthesis and drug development processes. It may serve as a building block for more complex pharmaceutical compounds or as a reagent in specialized chemical reactions. Its specific applications are typically limited to professional and industrial use due to its hazardous classification.

How to safely handle 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride requires strict safety protocols due to its Acute Tox. 3, Muta. 2, and Skin Sens. 1 classifications. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin contact, inhalation, and ingestion. Use appropriate engineering controls and follow established laboratory safety procedures when handling this hazardous substance.

How to properly store 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from incompatible materials. Due to its mutagenic and toxic properties, storage should comply with local hazardous substance regulations. Keep containers properly labeled and store separately from food, feed, and consumer products. Implement appropriate containment measures to prevent environmental release, considering its Aquatic Acute 1 and Aquatic Chronic 1 classifications.

What to do in case of contact with 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?

Immediate action is required upon contact with 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride due to its acute toxicity and skin sensitization properties. For skin contact, remove contaminated clothing and rinse thoroughly with water for at least 15 minutes. In case of eye contact, flush immediately with clean water. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet and contact emergency services when necessary.

How to properly dispose of 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride must be disposed of as hazardous waste in accordance with local, national, and international regulations. Due to its environmental hazard classification (Aquatic Acute 1, Aquatic Chronic 1), prevent release to waterways or soil. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Never dispose of through regular waste streams or pour down drains. Maintain proper documentation of disposal activities as required by applicable regulations.

How to transport 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is classified under ADR Class 6.1 (Toxic substances), Packing Group II, indicating significant transport restrictions. Shipments must comply with dangerous goods regulations including proper packaging, labeling, and documentation. Use UN-approved packaging suitable for Packing Group II substances. Transport vehicles must carry appropriate safety equipment and emergency response information. Only qualified personnel should handle transportation, and all applicable national and international transport regulations must be followed.

Is 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride subject to specific regulations?

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is subject to multiple regulatory frameworks including REACH registration requirements in Europe and CLP classification regulations. While not currently listed as a Substance of Very High Concern (SVHC), its mutagenic properties (Muta. 2) may trigger additional regulatory scrutiny. Users must comply with occupational health and safety regulations, environmental protection laws, and chemical transport regulations. Regular monitoring of regulatory updates is essential as classification and restrictions may change.

Where to buy 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride in Europe?

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is available through OYSI, a European distributor specializing in technical chemical products. As a professional chemical supplier, OYSI ensures compliance with all applicable European regulations including REACH and CLP requirements. Due to the hazardous nature of this compound, purchases are typically restricted to qualified industrial and research customers with appropriate handling capabilities and regulatory compliance. Contact OYSI directly for availability, technical specifications, and regulatory documentation.

Services for 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride

ADR Consulting for 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride

1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is a dangerous good. We support you with labeling, packaging, and transport documentation.

Request ADR Advice

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.