1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride
C8H14ClN3O2S
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Identification
- CAS Number
- 81880-96-8
- EC Number
- 406-090-1
- UN Number
- 2811
- Index Number
- 007-025-00-6
- PubChem CID
- 14234263
Physical-chemical properties
- Molecular Formula
- C8H14ClN3O2S
- Molar Mass
- 251.73 g/mol
- IUPAC Name
- 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride
Chemical Identifiers
- InChI
- InChI=1S/C8H13N3O2S.ClH/c1-10-14(12,13)6-7-2-4-8(11-9)5-3-7;/h2-5,10-11H,6,9H2,1H3;1H
- InChI Key
- WZZPGBAXFSIKJJ-UHFFFAOYSA-N
Overview
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide hydrochloride (CAS 81880-96-8) is an organic sulfonamide compound with hydrazine functionality and significant biological activity potential. This specialized chemical compound represents a unique combination of sulfonamide and hydrazine structural elements, making it particularly valuable in pharmaceutical research and chemical synthesis applications. With the molecular formula C8H14ClN3O2S and a molecular weight of 251.73 g/mol, this hydrochloride salt form ensures enhanced stability and solubility compared to its free base counterpart. The compound's structure features a phenyl ring substituted with both hydrazine and N-methylmethanesulfonamide groups, creating a versatile platform for further chemical modifications. This structural arrangement shares similarities with phenylhydrazine derivatives, though the additional sulfonamide functionality provides distinct reactivity patterns and potential applications. Safety considerations are paramount when handling this material, as it carries significant hazard classifications including mutagenicity (Muta. 2), acute toxicity (Acute Tox. 3), and specific target organ toxicity with repeated exposure (STOT RE 1). The compound also presents skin sensitization potential and aquatic toxicity concerns, requiring appropriate handling protocols and environmental protection measures during use. Primary industrial applications include pharmaceutical intermediate synthesis, particularly in the development of bioactive compounds where both hydrazine and sulfonamide pharmacophores are desired. The compound also finds use in specialized organic synthesis reactions and as a research chemical for medicinal chemistry programs. Its structural relationship to N-methylaniline-derived compounds makes it valuable for developing novel therapeutic agents. As a trusted European distributor of technical chemicals, OYSI maintains reliable supplies of 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide hydrochloride to support pharmaceutical research and specialized manufacturing requirements across Europe.
Safety & Classification
Muta. 2; Acute Tox. 3 *; STOT RE 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 2811 |
| ADR Class | 6.1 |
| Packing Group | II |
| Tunnel Code | D/E |
| Proper Shipping Name | (4-Hydrazinophenyl)-N-methylmethansulfonamid-hydrochlorid |
| Marine Pollutant | No |
Frequently Asked Questions
What is 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is an organic chemical compound with the molecular formula C8H14ClN3O2S and CAS number 81880-96-8. This substance has a molecular weight of 251.73 g/mol and contains hydrazine, phenyl, and sulfonamide functional groups. It is classified as a hazardous chemical requiring special handling precautions due to its mutagenic properties, acute toxicity, and environmental concerns.
What are the physicochemical properties of 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is a crystalline solid compound with a molecular weight of 251.73 g/mol and formula C8H14ClN3O2S. As a hydrochloride salt, it typically exhibits good water solubility and stability. The compound contains multiple functional groups including hydrazine, aromatic phenyl ring, and methanesulfonamide moiety, which influence its chemical reactivity and physical characteristics.
What is 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride used for?
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is primarily used as a chemical intermediate in pharmaceutical and fine chemical synthesis. Its hydrazine and sulfonamide functional groups make it valuable for developing pharmaceutical compounds and specialty chemicals. The substance is typically utilized in research laboratories and industrial manufacturing processes where controlled chemical transformations are required, particularly in medicinal chemistry applications.
How to handle 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride safely?
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride requires careful handling due to its mutagenic properties and acute toxicity classification. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and laboratory coats. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin and eye contact, and ensure proper training on emergency procedures before handling this hazardous substance.
How to store 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride correctly?
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride should be stored in a cool, dry, well-ventilated area away from incompatible materials. Keep containers tightly closed and properly labeled according to GHS requirements. Due to its hazardous classification, store in designated areas with restricted access and appropriate secondary containment. Protect from moisture, heat sources, and direct sunlight to maintain chemical stability and prevent degradation.
What to do in case of contact with 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?
Immediate action is required upon contact with 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride due to its acute toxicity. For skin contact, remove contaminated clothing and rinse thoroughly with water for at least 15 minutes. In case of eye contact, flush immediately with water and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical care while providing safety data sheet information.
How to dispose of 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride appropriately?
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride must be disposed of as hazardous waste according to local and EU regulations due to its mutagenic and toxic properties. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Never dispose of this substance in regular waste streams or sewage systems due to its environmental toxicity classification. Maintain proper documentation of waste disposal as required by environmental regulations.
How to transport 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride?
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is classified under ADR Class 6.1 (Toxic substances), Packing Group II, indicating significant transport restrictions. Proper UN-approved packaging, labeling, and documentation are mandatory for shipment. Transportation must comply with dangerous goods regulations, including driver training requirements and route restrictions. Ensure proper placarding of vehicles and emergency response information availability during transport.
Is 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride subject to specific regulations?
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is subject to comprehensive chemical regulations including REACH registration requirements and CLP classification as Muta. 2, Acute Tox. 3, STOT RE 1, and Skin Sens. 1. While not currently listed as SVHC, its mutagenic classification requires strict compliance with occupational exposure limits and safety protocols. Users must maintain safety data sheets and ensure proper worker training and protection measures.
Where to buy 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride in Europe?
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is available through OYSI, a specialized European distributor of technical chemicals. As a professional chemical supplier, OYSI provides this compound to qualified industrial and research customers with proper documentation and regulatory compliance. Contact OYSI directly for availability, technical specifications, and purchasing requirements, ensuring your organization meets the necessary qualifications for handling this hazardous substance.
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ADR Consulting for 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride
1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride is a dangerous good. We support you with labeling, packaging, and transport documentation.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.