4-(4-aminophenyl)sulfanylaniline

C12H12N2S

CAS139-65-1
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
139-65-1
EC Number
205-370-9
UN Number
3077
Index Number
612-198-00-1
PubChem CID
8765

Physical-chemical properties

Molecular Formula
C12H12N2S
Molar Mass
216.30 g/mol
IUPAC Name
4-(4-aminophenyl)sulfanylaniline

Chemical Identifiers

InChI
InChI=1S/C12H12N2S/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8H,13-14H2
InChI Key
ICNFHJVPAJKPHW-UHFFFAOYSA-N

Overview

4-(4-aminophenyl)sulfanylaniline (CAS 139-65-1) is an aromatic amine compound with sulfur bridging functionality between two aminophenyl groups. This organic chemical substance, also known by its EC number 205-370-9, belongs to the class of diphenylsulfide derivatives with a molecular formula of C12H12N2S and molecular weight of 216.3 g/mol. The compound features two aniline groups connected through a sulfur atom, creating a symmetrical structure that imparts unique chemical properties valuable in industrial applications. From a safety perspective, 4-(4-aminophenyl)sulfanylaniline carries significant hazard classifications requiring careful handling. It is classified as Carcinogenic Category 1B, indicating strong evidence of carcinogenic potential, along with Acute Toxicity Category 4 and Aquatic Chronic Toxicity Category 2. These classifications necessitate the "Danger" signal word and corresponding GHS pictograms GHS08 (health hazard), GHS07 (harmful), and GHS09 (environmental hazard). For transportation purposes, it falls under ADR Class 9 for miscellaneous dangerous goods. The compound finds primary applications in the chemical industry as an intermediate for dye synthesis, particularly in the production of sulfur-containing colorants and pigments. It also serves as a building block in pharmaceutical intermediates and specialty chemical manufacturing. Related compounds in this chemical family include 4-(4-amino-3-methylphenyl)-2-methylaniline, which shares similar aromatic amine functionality but with different substitution patterns. Due to its hazardous nature, proper risk assessment, specialized storage conditions, and appropriate personal protective equipment are essential when handling this substance. OYSI maintains availability of 4-(4-aminophenyl)sulfanylaniline for qualified industrial customers with appropriate safety protocols and regulatory compliance requirements.

Safety & Classification

Danger
Classification:

Carc. 1B; Acute Tox. 4 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H302

Harmful if swallowed.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name4,4'-Thiodianilin
Marine PollutantNo

Frequently Asked Questions

What is 4-(4-aminophenyl)sulfanylaniline?

4-(4-aminophenyl)sulfanylaniline is an organic chemical compound with the molecular formula C12H12N2S and CAS number 139-65-1. This aromatic amine features two aminophenyl groups connected by a sulfur bridge, giving it a molecular weight of 216.3 g/mol. It belongs to the class of sulfur-containing aromatic compounds and is classified as a Category 1B carcinogen under CLP regulation, requiring careful handling and strict safety measures.

What are the physicochemical properties of 4-(4-aminophenyl)sulfanylaniline?

4-(4-aminophenyl)sulfanylaniline is a solid organic compound at room temperature with a molecular weight of 216.3 g/mol. As an aromatic amine containing sulfur, it typically appears as a crystalline powder. The compound contains two amino groups and a sulfur bridge, making it moderately polar. Its exact melting point, boiling point, and solubility characteristics should be verified from technical data sheets for specific handling requirements.

What is 4-(4-aminophenyl)sulfanylaniline used for?

4-(4-aminophenyl)sulfanylaniline is primarily used as an intermediate in chemical synthesis and manufacturing processes. Its structure makes it valuable in the production of dyes, pigments, and other aromatic compounds. It may also serve as a building block in pharmaceutical research and specialty chemical manufacturing. Due to its carcinogenic classification, its use is restricted to professional and industrial applications with appropriate safety controls.

How to handle 4-(4-aminophenyl)sulfanylaniline safely?

4-(4-aminophenyl)sulfanylaniline requires strict safety protocols due to its Carc. 1B and Acute Tox. 4 classifications. Use appropriate respiratory protection, chemical-resistant gloves, and protective clothing to prevent skin and inhalation exposure. Work in well-ventilated areas or under fume hoods. Avoid dust generation and ensure proper containment. Regular health monitoring may be required for workers handling this substance due to its carcinogenic properties.

How to store 4-(4-aminophenyl)sulfanylaniline correctly?

4-(4-aminophenyl)sulfanylaniline should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers protected from light and moisture. Storage areas must be restricted to authorized personnel only due to the carcinogenic nature of the substance. Ensure proper labeling with hazard pictogrammes GHS07, GHS08, and GHS09, and maintain an inventory for regulatory compliance.

What to do in case of contact with 4-(4-aminophenyl)sulfanylaniline?

Skin contact with 4-(4-aminophenyl)sulfanylaniline requires immediate removal of contaminated clothing and thorough washing with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. Seek medical attention promptly in all cases of exposure, informing healthcare providers of the substance's carcinogenic properties and providing the safety data sheet.

How to dispose of 4-(4-aminophenyl)sulfanylaniline appropriately?

4-(4-aminophenyl)sulfanylaniline waste must be disposed of through licensed hazardous waste contractors in accordance with local and European waste regulations. The substance cannot be disposed of in regular waste streams due to its carcinogenic classification and environmental hazard rating (Aquatic Chronic 2). Waste containers must be properly labeled and segregated. Incineration at authorized high-temperature facilities is typically the preferred disposal method for such aromatic compounds.

How to transport 4-(4-aminophenyl)sulfanylaniline?

4-(4-aminophenyl)sulfanylaniline is classified under ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation. Packages must display proper hazard labels and UN identification numbers. Transport documents must include the correct shipping name and hazard information. Drivers require ADR training for Class 9 substances. Ensure packages are properly sealed, labeled with GHS pictogrammes, and accompanied by safety data sheets during transport.

Is 4-(4-aminophenyl)sulfanylaniline subject to specific regulations?

4-(4-aminophenyl)sulfanylaniline is subject to strict European regulations under CLP for classification and labeling as Carc. 1B. REACH registration requirements apply for importers and manufacturers. While not currently listed as SVHC, its carcinogenic classification means it may face future restrictions. Occupational exposure limits and health surveillance requirements apply in workplace settings. Companies must maintain detailed records and implement risk management measures for regulatory compliance.

Where to buy 4-(4-aminophenyl)sulfanylaniline in Europe?

4-(4-aminophenyl)sulfanylaniline is available through OYSI, a specialized European distributor of technical chemicals. As a carcinogenic substance requiring professional handling, it is only supplied to qualified industrial customers with appropriate safety infrastructure and regulatory compliance. OYSI provides technical support, safety documentation, and ensures proper packaging and transport according to ADR Class 9 requirements for this hazardous chemical intermediate.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.