4-(4-aminophenyl)sulfanylaniline

C12H12N2S

CAS139-65-1
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
139-65-1
EC Number
205-370-9
UN Number
3077
Index Number
612-198-00-1
PubChem CID
8765

Physical-chemical properties

Molecular Formula
C12H12N2S
Molar Mass
216.30 g/mol
IUPAC Name
4-(4-aminophenyl)sulfanylaniline

Chemical Identifiers

InChI
InChI=1S/C12H12N2S/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8H,13-14H2
InChI Key
ICNFHJVPAJKPHW-UHFFFAOYSA-N

Overview

4-(4-aminophenyl)sulfanylaniline (CAS 139-65-1) is an aromatic amine compound with sulfur linkage between two aminophenyl groups, classified as a carcinogenic substance. This organic compound, also known by its EC number 205-370-9, belongs to the family of diaryl sulfides containing amino functional groups. With a molecular formula of C12H12N2S and molecular weight of 216.3 g/mol, this substance exhibits the characteristic properties of aromatic amines combined with sulfur-bridged structures. The compound's structure features two para-aminophenyl groups connected through a sulfur atom, creating a symmetrical molecule with significant industrial relevance. From a safety perspective, 4-(4-aminophenyl)sulfanylaniline carries serious health hazards and requires stringent handling protocols. Classified as Category 1B carcinogenic under CLP regulation, it poses significant cancer risks upon exposure. The substance also exhibits acute toxicity (Category 4) and chronic aquatic toxicity (Category 2), necessitating appropriate personal protective equipment and environmental controls. The GHS08, GHS07, and GHS09 pictograms indicate health hazards, acute toxicity, and environmental dangers respectively, while the ADR Class 9 classification governs its transport as a miscellaneous dangerous substance. Industrial applications primarily center around chemical synthesis and manufacturing processes where aromatic amine intermediates are required. The compound serves as a precursor in dye manufacturing and pharmaceutical synthesis, where its dual amino functionality provides reactive sites for further chemical modifications. Similar compounds in this chemical family include 4-(4-amino-3-methylphenyl)-2-methylaniline, which shares structural similarities and comparable applications in industrial synthesis. OYSI maintains strict quality standards and regulatory compliance for this specialized chemical intermediate, ensuring proper documentation and safe handling procedures for professional customers across Europe.

Safety & Classification

Danger
Classification:

Carc. 1B; Acute Tox. 4 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H302

Harmful if swallowed.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name4,4'-Thiodianilin
Marine PollutantNo

Frequently Asked Questions

What is 4-(4-aminophenyl)sulfanylaniline?

4-(4-aminophenyl)sulfanylaniline is an organic chemical compound with the molecular formula C12H12N2S and CAS number 139-65-1. This aromatic amine contains two phenyl rings connected by a sulfur bridge, with amino groups on both rings. It has a molecular weight of 216.3 g/mol and is classified as a carcinogenic substance (Category 1B) requiring careful handling under appropriate safety protocols.

What are the physicochemical properties of 4-(4-aminophenyl)sulfanylaniline?

4-(4-aminophenyl)sulfanylaniline is a solid aromatic compound at room temperature with a molecular weight of 216.3 g/mol. As an aromatic amine with sulfur bridging, it typically exhibits limited water solubility but may dissolve in organic solvents. The compound contains two amino groups that can participate in hydrogen bonding and various chemical reactions typical of aromatic amines.

What is 4-(4-aminophenyl)sulfanylaniline used for?

4-(4-aminophenyl)sulfanylaniline is primarily used as an intermediate in chemical synthesis and pharmaceutical manufacturing. Its aromatic amine structure makes it valuable for producing dyes, pigments, and various organic compounds. Due to its carcinogenic classification, its use is restricted to professional industrial applications with appropriate safety controls and regulatory compliance.

How to handle 4-(4-aminophenyl)sulfanylaniline safely?

4-(4-aminophenyl)sulfanylaniline requires strict safety measures due to its carcinogenic properties (Carc. 1B). Essential protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin contact, inhalation, and ingestion. Implement appropriate containment measures and ensure personnel are trained in carcinogen handling procedures.

How to store 4-(4-aminophenyl)sulfanylaniline correctly?

4-(4-aminophenyl)sulfanylaniline should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed and labeled according to GHS requirements. Storage areas must be secured and accessible only to authorized personnel due to the carcinogenic nature. Implement appropriate inventory control and ensure compliance with local regulations for carcinogenic substances.

What to do in case of contact with 4-(4-aminophenyl)sulfanylaniline?

4-(4-aminophenyl)sulfanylaniline exposure requires immediate action due to its toxicity. For skin contact, immediately remove contaminated clothing and wash thoroughly with soap and water. In case of eye contact, flush with clean water for at least 15 minutes. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention, informing healthcare providers of the carcinogenic nature.

How to dispose of 4-(4-aminophenyl)sulfanylaniline appropriately?

4-(4-aminophenyl)sulfanylaniline disposal must comply with hazardous waste regulations due to its carcinogenic classification. The substance cannot be disposed of as regular waste and requires specialized hazardous waste treatment facilities. Contact licensed waste disposal companies experienced in handling carcinogenic materials. Maintain proper documentation and chain of custody throughout the disposal process as required by local environmental regulations.

How to transport 4-(4-aminophenyl)sulfanylaniline?

4-(4-aminophenyl)sulfanylaniline is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transport purposes. Packages must be properly labeled with appropriate hazard markings and GHS pictograms (GHS07, GHS08, GHS09). Transport documents must include proper shipping names and hazard classifications. Ensure carriers are trained in dangerous goods handling and emergency procedures for carcinogenic substances.

Is 4-(4-aminophenyl)sulfanylaniline subject to specific regulations?

4-(4-aminophenyl)sulfanylaniline is subject to extensive regulatory control under REACH and CLP regulations in Europe due to its carcinogenic classification (Category 1B). While not currently listed as a SVHC, its use may be restricted or require authorization depending on applications. Companies must comply with occupational exposure limits, implement risk management measures, and maintain appropriate safety data sheets and exposure scenarios.

Where to buy 4-(4-aminophenyl)sulfanylaniline in Europe?

4-(4-aminophenyl)sulfanylaniline is available through OYSI, a specialized European distributor of technical chemicals. As a carcinogenic substance, purchase is restricted to qualified industrial users who can demonstrate appropriate handling capabilities and regulatory compliance. OYSI provides technical support and ensures proper documentation for this controlled substance, facilitating safe and compliant procurement for authorized applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.