Methyl 4-(bromomethyl)-3-methoxybenzoate

Methyl 4-(bromomethyl)-3-methoxybenzoate is an organobromine compound with the molecular formula C10H11BrO3 and CAS number 70264-94-7. This aromatic ester features a benzene ring substituted with a bromomethyl group, a methoxy group, and a methyl ester functionality. With a molecular weight of 259.1 g/mol, it appears as a solid compound that poses significant safety concerns due to its corrosive and sensitizing properties.

Methyl 4-(bromomethyl)-3-methoxybenzoate is typically a white to off-white crystalline solid at room temperature. The compound contains both polar (ester, methoxy) and nonpolar (aromatic ring) regions, making it moderately soluble in organic solvents like alcohols and ethers but poorly soluble in water. Its bromine content contributes to its relatively high molecular weight and density compared to similar non-halogenated compounds.

Methyl 4-(bromomethyl)-3-methoxybenzoate serves primarily as an intermediate in pharmaceutical and fine chemical synthesis. The reactive bromomethyl group makes it valuable for nucleophilic substitution reactions, allowing chemists to introduce various functional groups. It is commonly used in the preparation of bioactive compounds, pharmaceutical intermediates, and specialty chemicals where selective functionalization of aromatic systems is required in research and manufacturing processes.

Methyl 4-(bromomethyl)-3-methoxybenzoate requires careful handling due to its corrosive and sensitizing properties. Always wear appropriate PPE including chemical-resistant gloves, safety goggles, and protective clothing when handling this substance. Work in well-ventilated areas or under fume hoods to avoid inhalation. The compound can cause severe eye damage and skin irritation, so avoid direct contact. Use proper laboratory techniques and ensure emergency eyewash stations are accessible.

Methyl 4-(bromomethyl)-3-methoxybenzoate should be stored in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers tightly sealed to prevent moisture absorption and degradation. Store separately from strong bases, nucleophiles, and reducing agents due to the reactive bromomethyl group. Ensure storage areas have appropriate spill containment measures and are accessible only to trained personnel familiar with handling hazardous chemicals.

Skin contact with methyl 4-(bromomethyl)-3-methoxybenzoate requires immediate removal of contaminated clothing and thorough washing with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention due to potential serious eye damage. If inhaled, move to fresh air immediately. Remove contaminated clothing and wash before reuse. Seek medical attention if irritation persists or symptoms develop.

Methyl 4-(bromomethyl)-3-methoxybenzoate must be disposed of as hazardous waste through licensed waste disposal companies. Do not pour down drains or dispose of in regular waste due to its environmental hazard classification (Aquatic Acute 1, Aquatic Chronic 1). Collect waste in properly labeled containers and arrange disposal according to local and national regulations. Small quantities may be suitable for controlled incineration at appropriate high-temperature facilities with emission controls.

Methyl 4-(bromomethyl)-3-methoxybenzoate is classified as ADR Class 8 (corrosive substances), Packing Group III for transportation purposes. This classification requires appropriate corrosive-resistant packaging and proper hazard labeling during shipment. Transport containers must meet UN specification requirements and display appropriate hazard diamonds. Shipping documentation must include proper shipping names, hazard classifications, and emergency response information. Only trained personnel should handle transportation arrangements.

Methyl 4-(bromomethyl)-3-methoxybenzoate falls under REACH regulation in Europe and requires compliance with CLP classification requirements. While not currently listed as an SVHC (Substance of Very High Concern), its hazardous properties require proper classification, labeling, and safety data sheet provision. Users must follow occupational exposure limits and implement appropriate risk management measures. The compound's environmental hazard classification may trigger additional reporting requirements under local environmental regulations.

Methyl 4-(bromomethyl)-3-methoxybenzoate is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound with full regulatory compliance, including proper documentation, safety data sheets, and certificates of analysis. As experienced chemical distributors, OYSI ensures proper packaging, handling, and delivery throughout Europe while maintaining the highest quality standards for research and industrial applications.