Methyl 4-(bromomethyl)-3-methoxybenzoate

Methyl 4-(bromomethyl)-3-methoxybenzoate is an organobromine compound with the molecular formula C10H11BrO3 and CAS number 70264-94-7. This chemical features a benzoate ester structure with a bromomethyl substituent and a methoxy group. With a molecular weight of 259.1 g/mol, it belongs to the class of aromatic esters and is commonly used as an intermediate in organic synthesis and pharmaceutical manufacturing.

Methyl 4-(bromomethyl)-3-methoxybenzoate appears as a solid compound at room temperature with characteristic properties of aromatic esters. The presence of the bromine atom and methoxy group influences its solubility profile, typically showing good solubility in organic solvents like alcohols and ethers but limited water solubility. Its molecular structure contributes to its stability under normal conditions while maintaining reactivity at the bromomethyl position.

Methyl 4-(bromomethyl)-3-methoxybenzoate serves primarily as a synthetic intermediate in pharmaceutical and fine chemical manufacturing. The compound is valuable in organic synthesis due to its reactive bromomethyl group, which enables nucleophilic substitution reactions. It finds applications in the production of pharmaceutical active ingredients, specialty chemicals, and research compounds where selective bromination and esterification are required for molecular construction.

Methyl 4-(bromomethyl)-3-methoxybenzoate requires careful handling due to its skin irritant, eye damaging, and sensitizing properties. Essential protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to minimize exposure. Avoid skin and eye contact, and prevent inhalation of dust or vapors. The compound carries a 'Danger' signal word and requires adherence to strict safety protocols during use.

Methyl 4-(bromomethyl)-3-methoxybenzoate should be stored in tightly closed containers in a cool, dry, well-ventilated area away from incompatible materials. Keep away from heat sources, direct sunlight, and moisture to prevent degradation. Due to its aquatic toxicity classification, ensure proper containment to prevent environmental release. Store separately from strong bases and reducing agents that may react with the bromomethyl group, and maintain appropriate temperature conditions as specified by the supplier.

Immediate action is crucial upon contact with methyl 4-(bromomethyl)-3-methoxybenzoate due to its irritant and potentially eye-damaging properties. For skin contact, immediately wash with plenty of water for at least 15 minutes and remove contaminated clothing. In case of eye contact, rinse thoroughly with water for at least 15 minutes and seek immediate medical attention. If inhaled, move to fresh air. Remove contaminated clothing and wash before reuse. Always consult a physician if irritation persists.

Methyl 4-(bromomethyl)-3-methoxybenzoate must be disposed of as hazardous waste in accordance with local and international environmental regulations. Due to its aquatic toxicity classification, prevent release to water systems and soil. Contact licensed waste disposal companies specializing in organohalogen compounds. Incineration at high temperatures in approved facilities is typically the preferred method. Small quantities may require collection in designated hazardous waste containers following applicable waste codes and classification requirements.

Methyl 4-(bromomethyl)-3-methoxybenzoate is classified under ADR Class 8 (Corrosive substances), Packing Group III for transportation purposes. Packages must comply with appropriate packing instructions and bear proper hazard labels including corrosive substance markings. Transport vehicles require ADR compliance, and drivers need appropriate training certifications. Proper documentation including transport documents and emergency response information must accompany shipments. Ensure packages are secured and protected from damage during transit.

Methyl 4-(bromomethyl)-3-methoxybenzoate is subject to REACH regulation requiring registration for manufacture or import above one tonne per year. CLP regulation mandates proper classification and labeling with GHS pictograms GHS05, GHS07, and GHS09. The compound is not currently listed as an SVHC substance. Users must comply with workplace exposure limits, environmental discharge restrictions due to its aquatic toxicity, and proper waste management protocols under various national and EU environmental directives.

Methyl 4-(bromomethyl)-3-methoxybenzoate is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound to pharmaceutical, fine chemical, and research industries across Europe with appropriate documentation including safety data sheets and certificates of analysis. As a professional chemical distributor, OYSI ensures compliance with European regulations and maintains high-quality standards for specialty organic compounds like this bromomethyl benzoate derivative.