1-dodecylpyrrolidin-2-one

1-dodecylpyrrolidin-2-one is an organic chemical compound with the molecular formula C16H31NO and CAS number 2687-96-9. This substance belongs to the pyrrolidinone family and features a twelve-carbon alkyl chain attached to the pyrrolidin-2-one ring structure. With a molecular weight of 253.42 g/mol, it is classified as a corrosive substance with significant skin sensitization properties and environmental hazards to aquatic life.

1-dodecylpyrrolidin-2-one is an organic compound with molecular formula C16H31NO and molecular weight of 253.42 g/mol. As a long-chain alkylated pyrrolidinone, it typically appears as a viscous liquid at room temperature. The compound's amphiphilic structure, combining the polar pyrrolidinone head group with a hydrophobic dodecyl chain, gives it surfactant-like properties and influences its solubility characteristics in both polar and non-polar solvents.

1-dodecylpyrrolidin-2-one is primarily used as a penetration enhancer and solubilizer in pharmaceutical and cosmetic formulations. Its unique chemical structure makes it effective in transdermal drug delivery systems, helping active ingredients penetrate biological membranes. The compound also finds applications in specialty chemical formulations where its surfactant properties and solubilizing capabilities are valuable for improving product performance and stability.

1-dodecylpyrrolidin-2-one requires careful handling due to its Skin Corr. 1B and Skin Sens. 1 classifications. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work in well-ventilated areas or use local exhaust ventilation. Avoid inhalation and ensure emergency eyewash stations and safety showers are readily accessible. Handle with appropriate chemical handling procedures to minimize exposure risks.

1-dodecylpyrrolidin-2-one should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Due to its corrosive nature (ADR Class 8, Group II), use compatible packaging materials and ensure containers are properly labeled with appropriate hazard warnings. Store separately from incompatible materials and ensure storage areas have appropriate spill containment measures and emergency response equipment readily available.

Immediate action is crucial due to 1-dodecylpyrrolidin-2-one's corrosive properties. For skin contact, immediately remove contaminated clothing and flush affected areas with copious amounts of water for at least 15 minutes. For eye contact, rinse thoroughly with clean water for at least 15 minutes while holding eyelids open. Seek immediate medical attention for any exposure. If inhaled, move to fresh air immediately and seek medical advice if breathing difficulties occur.

1-dodecylpyrrolidin-2-one disposal must comply with local, national, and EU waste regulations due to its hazardous classification. The substance should be treated as hazardous waste and disposed of through licensed waste management facilities capable of handling corrosive and environmentally hazardous materials. Never dispose of via regular drains or municipal waste systems. Consult with certified waste disposal companies and follow all applicable environmental protection guidelines for proper disposal procedures.

1-dodecylpyrrolidin-2-one is classified under ADR as Class 8 (corrosive substances), Packing Group II, indicating moderate danger level. Transportation requires appropriate corrosive-resistant packaging, proper hazard labeling with GHS05, GHS07, and GHS09 pictogrammes, and compliance with dangerous goods transport regulations. Vehicles must carry appropriate emergency equipment and documentation. Only trained personnel should handle transportation, and routes should avoid environmentally sensitive areas due to the substance's aquatic toxicity classification.

1-dodecylpyrrolidin-2-one is subject to standard EU chemical regulations including REACH registration and CLP classification requirements. While not currently listed as an SVHC (Substance of Very High Concern), its multiple hazard classifications require compliance with occupational health and safety regulations, environmental protection measures, and proper hazard communication. Users must ensure appropriate risk assessments, safety data sheets, and worker protection measures are in place according to applicable legislation.

1-dodecylpyrrolidin-2-one is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this substance to industrial and research customers across Europe, ensuring proper regulatory compliance, appropriate packaging, and technical support. As a professional chemical distributor, OYSI maintains quality standards and provides necessary documentation including safety data sheets and certificates of analysis to meet customer requirements and regulatory obligations.