1-dodecylpyrrolidin-2-one

1-dodecylpyrrolidin-2-one is a synthetic organic compound with the molecular formula C16H31NO and CAS number 2687-96-9. This pyrrolidone derivative features a 12-carbon alkyl chain attached to the nitrogen atom of the pyrrolidin-2-one ring structure. With a molecular weight of 253.42 g/mol, it belongs to the family of N-alkylpyrrolidones, which are known for their solvent and penetration-enhancing properties in various industrial applications.

1-dodecylpyrrolidin-2-one is typically a liquid at room temperature with amphiphilic properties due to its polar pyrrolidone head group and long hydrophobic alkyl chain. The compound exhibits good solubility in organic solvents and limited water solubility. Its structure provides both hydrophilic and lipophilic characteristics, making it an effective surfactant and penetration enhancer. The long dodecyl chain contributes to its surface-active properties and ability to interact with lipid membranes.

1-dodecylpyrrolidin-2-one is primarily used as a penetration enhancer in pharmaceutical and cosmetic formulations, improving the delivery of active ingredients through biological membranes. It serves as a solubilizer and surfactant in various industrial applications. The compound is also employed in research for drug delivery systems and membrane permeation studies. Its amphiphilic properties make it valuable in formulations requiring enhanced bioavailability and controlled release of active substances.

1-dodecylpyrrolidin-2-one must be handled with extreme caution as it is classified as corrosive to skin (Skin Corr. 1B) and a skin sensitizer (Skin Sens. 1). Wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. Prevent direct skin and eye contact at all costs. Have emergency eyewash and shower facilities readily available in the work area.

1-dodecylpyrrolidin-2-one should be stored in tightly sealed, corrosion-resistant containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers upright and ensure secondary containment to prevent spills. Store away from incompatible materials and oxidizing agents. Maintain storage temperature as recommended by the manufacturer. Access should be restricted to trained personnel only, and storage areas must be clearly labeled with appropriate hazard warnings and safety information.

1-dodecylpyrrolidin-2-one contact requires immediate action due to its corrosive properties. For skin contact, immediately remove contaminated clothing and rinse affected area with copious amounts of water for at least 15 minutes. For eye contact, flush immediately with water for at least 15 minutes while holding eyelids open. Seek immediate medical attention for any exposure. If inhaled, move to fresh air immediately. Do not induce vomiting if swallowed; rinse mouth and seek medical care immediately.

1-dodecylpyrrolidin-2-one disposal must comply with local and international environmental regulations due to its aquatic toxicity classification (Aquatic Acute 1; Aquatic Chronic 1). Never discharge into sewers, waterways, or soil. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities may require neutralization or incineration at authorized facilities. Contaminated containers and materials must also be disposed of as hazardous waste. Always consult current regulatory guidelines before disposal.

1-dodecylpyrrolidin-2-one is classified under ADR Class 8 (Corrosive substances), Packing Group II, indicating it poses significant transport hazards. Transportation requires appropriate corrosive substance packaging, labeling, and documentation according to dangerous goods regulations. Vehicles must carry proper emergency equipment and placarding. Only authorized carriers experienced in hazardous materials transport should handle shipments. Ensure packages are properly sealed, labeled, and accompanied by safety data sheets and transport documents.

1-dodecylpyrrolidin-2-one is subject to REACH regulation requirements for registration, evaluation, and authorization in the European Union. While not currently listed as a Substance of Very High Concern (SVHC), its hazardous properties require compliance with CLP classification and labeling regulations. Users must implement appropriate risk management measures and provide safety data sheets. Transport regulations under ADR/RID apply for shipments. Additional sector-specific regulations may apply depending on intended use in pharmaceuticals, cosmetics, or industrial applications.

1-dodecylpyrrolidin-2-one is available through OYSI, a European distributor specializing in technical and specialty chemicals. OYSI provides this compound to pharmaceutical, cosmetic, and research industries across Europe with appropriate documentation including certificates of analysis and safety data sheets. As a specialized chemical requiring expert handling knowledge, purchasing from experienced distributors like OYSI ensures proper regulatory compliance, packaging, and technical support for safe handling and application in your specific requirements.