Methyl 3-oxobutanoate

Methyl 3-oxobutanoate is an organic chemical compound with the molecular formula C5H8O3 and CAS number 105-45-3. This ester belongs to the family of beta-keto esters and has a molecular weight of 116.11 g/mol. It is classified as an eye irritant (Eye Irrit. 2) under GHS classification and carries a warning signal word with the GHS07 pictogram for health hazards.

Methyl 3-oxobutanoate is typically a colorless to pale yellow liquid at room temperature with a characteristic fruity odor. As an ester with moderate polarity, it shows good solubility in organic solvents like ethanol, acetone, and ether, while having limited solubility in water. The compound has a boiling point around 169-171°C and a density of approximately 1.08 g/cm³.

Methyl 3-oxobutanoate serves primarily as an important intermediate in organic synthesis and pharmaceutical manufacturing. It is widely used in the production of various pharmaceuticals, agrochemicals, and fine chemicals. The compound also finds applications in flavor and fragrance industries due to its fruity odor profile, and serves as a building block for more complex organic molecules in chemical research and development.

Methyl 3-oxobutanoate should be handled with appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation of vapors. Since it causes eye irritation (Eye Irrit. 2), particular attention must be paid to eye protection. Avoid skin contact and ensure proper ventilation during use to minimize exposure risks.

Methyl 3-oxobutanoate should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and direct sunlight. Keep containers upright and protected from physical damage. Store away from strong oxidizing agents and bases that could react with the ester functionality. Maintain storage temperatures below 25°C and ensure proper labeling according to GHS requirements with warning pictograms.

In case of eye contact with methyl 3-oxobutanoate, immediately flush eyes with plenty of clean water for at least 15 minutes and seek medical attention due to its eye irritant properties. For skin contact, wash thoroughly with soap and water. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician if symptoms persist.

Methyl 3-oxobutanoate waste must be disposed of according to local and national environmental regulations. The compound should not be released into drains, soil, or waterways. Contact licensed waste disposal companies for proper treatment and disposal. Small laboratory quantities can often be incinerated at appropriate high-temperature facilities. Always consult local environmental authorities for specific disposal requirements and maintain proper waste documentation.

Methyl 3-oxobutanoate transport should follow general chemical shipping guidelines as no specific ADR classification is assigned. Use appropriate packaging that prevents leakage and breakage during transport. Ensure containers are properly labeled with GHS hazard information including the warning signal word and GHS07 pictogram. Follow standard chemical transport protocols and maintain proper documentation including safety data sheets during shipment.

Methyl 3-oxobutanoate is subject to REACH regulation in Europe and must comply with CLP classification as Eye Irrit. 2. It is not listed as a Substance of Very High Concern (SVHC). Users must follow standard chemical safety regulations including proper labeling, safety data sheet provision, and workplace exposure controls. Ensure compliance with local occupational health and safety requirements when handling this eye irritant substance.

Methyl 3-oxobutanoate is available through OYSI, a European chemical distributor specializing in high-quality chemical products. OYSI provides reliable supply chains across Europe with proper documentation including certificates of analysis and safety data sheets. As an established chemical supplier, OYSI ensures compliance with European regulations and provides technical support for safe handling and application of methyl 3-oxobutanoate.